Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Ciara McDonnell"'
Autor:
Mairéad T. Crowley, Eirena Goulden, Begona Sanchez-Lechuga, Aileen Fleming, Maria Kennelly, Ciara McDonnell, Maria M. Byrne
Publikováno v:
Clinical Diabetes and Endocrinology, Vol 10, Iss 1, Pp 1-7 (2024)
Abstract Background Heterozygous insulin receptor mutations (INSR) are associated with insulin resistance, hyperglycaemia and hyperinsulinaemic hypoglycaemia in addition to hyperandrogenism and oligomenorrhoea in women. Numerous autosomal dominant he
Externí odkaz:
https://doaj.org/article/4f8318ac21f74445a9d841ebcefa8609
Autor:
Ravi Savarirayan, Daniel G. Hoernschemeyer, Merete Ljungberg, Yuri A. Zarate, Carlos A. Bacino, Michael B. Bober, Janet M. Legare, Wolfgang Högler, Teresa Quattrin, M. Jennifer Abuzzahab, Paul L. Hofman, Klane K. White, Nina S. Ma, Dirk Schnabel, Sérgio B. Sousa, Meng Mao, Alden Smith, Mukta Chakraborty, Adebola Giwa, Bent Winding, Birgitte Volck, Aimee D. Shu, Ciara McDonnell
Publikováno v:
EClinicalMedicine, Vol 65, Iss , Pp 102258- (2023)
Summary: Background: TransCon CNP (navepegritide) is an investigational prodrug of C-type natriuretic peptide (CNP) designed to allow for continuous CNP exposure with once-weekly dosing. This 52-week phase 2 (ACcomplisH) trial assessed the safety and
Externí odkaz:
https://doaj.org/article/07498b64dfd0403e9988b282f640b406
Autor:
Fionnuala M McAuliffe, Ciara McDonnell, Helena C Bartels, Linda M O'Keeffe, Cara A Yelverton, Kate N O'Neill
Publikováno v:
BMJ Open, Vol 13, Iss 3 (2023)
Objectives To model trajectories of antenatal and postnatal growth using linear spline multilevel models.Design Prospective cohort study.Setting Maternity hospital in Dublin, Ireland.Participants 720–759 mother–child pairs from the ROLO study (in
Externí odkaz:
https://doaj.org/article/d5917c24ca7548738a184411a7ea2b39
Autor:
Debra Smyth, Monica Hytiris, Coreen Kelday, Ciara McDonnell, Christine Burren, Adrian Gardner, Lisa Mills, Susan Parekh, Oliver Semler, Angela Stewart, Ingunn Westerheim, Muhammad Kassim Javaid, Patricia Osborne, S. Faisal Ahmed
Publikováno v:
Frontiers in Public Health, Vol 10 (2023)
BackgroundResearch on the effects of the COVID-19 pandemic on people with rare diseases is limited. Few studies compare healthcare throughout the progression of the ongoing pandemic.AimsTo assess the impact of the pandemic on individuals with osteoge
Externí odkaz:
https://doaj.org/article/5e25f3659191436a8bde0da47058f050
Autor:
Nicola Pirastu, Ciara McDonnell, Eryk J. Grzeszkowiak, Ninon Mounier, Fumiaki Imamura, Jordi Merino, Felix R. Day, Jie Zheng, Nele Taba, Maria Pina Concas, Linda Repetto, Katherine A. Kentistou, Antonietta Robino, Tõnu Esko, Peter K. Joshi, Krista Fischer, Ken K. Ong, Tom R. Gaunt, Zoltán Kutalik, John R. B. Perry, James F. Wilson
Publikováno v:
PLoS Genetics, Vol 18, Iss 6 (2022)
Diet is considered as one of the most important modifiable factors influencing human health, but efforts to identify foods or dietary patterns associated with health outcomes often suffer from biases, confounding, and reverse causation. Applying Mend
Externí odkaz:
https://doaj.org/article/f45a54236dc047c5bb6bc2085850d24a
Autor:
John Allen, Zunera Zareen, Samantha Doyle, Laura Whitla, Zainab Afzal, Maria Stack, Orla Franklin, Andrew Green, Adam James, Timothy Ronan Leahy, Shoana Quinn, Basil Elnazir, John Russell, Sri Paran, Patrick Kiely, Edna Frances Roche, Ciara McDonnell, Louise Baker, Owen Hensey, Louise Gibson, Stephanie Kelly, Denise McDonald, Eleanor J. Molloy
Publikováno v:
Frontiers in Pediatrics, Vol 9 (2021)
Cerebral Palsy (CP) describes a heterogenous group of non-progressive disorders of posture or movement, causing activity limitation, due to a lesion in the developing brain. CP is an umbrella term for a heterogenous condition and is, therefore, descr
Externí odkaz:
https://doaj.org/article/3524829d07ee401ba481b48169e2afa4
Autor:
Maire Curran, Audrey C. Tierney, Louise Collins, Lauren Kennedy, Ciara McDonnell, Andrew J. Jurascheck, Ali Sheikhi, Cathal Walsh, Brenda Button, Rose Galvin, Brian Casserly, Roisin Cahalan
Publikováno v:
HRB Open Research, Vol 3 (2020)
Background: Physical activity (PA) and exercise are widely documented as key components in the management of cystic fibrosis (CF). In recent years there have been significant improvements in telehealth, in particular; wearable technology, smartphone
Externí odkaz:
https://doaj.org/article/415baaaf14504312a7e1dc5ea97cda52
Publikováno v:
Molecules, Vol 20, Iss 6, Pp 10748-10762 (2015)
Cyclic seleninate esters function as mimetics of the antioxidant selenoenzyme glutathione peroxidase. They catalyze the reduction of harmful peroxides with thiols, which are converted to disulfides in the process. The possibility that the seleninate
Externí odkaz:
https://doaj.org/article/cb7f4239bfce449da7d94f77772113a9
Autor:
Brenda M. Button, Roisin Cahalan, Brian Casserly, Louise Collins, Ciara McDonnell, Audrey C. Tierney, Lauren Kennedy, Maire Curran
Publikováno v:
Journal of Cystic Fibrosis. 21:272-281
Physical activity (PA) and exercise have numerous benefits in Cystic Fibrosis (CF) including improved lung function, exercise capacity and quality of life. Despite these benefits, the effectiveness of interventions to promote PA in this population ar
Autor:
Timothy J. Brown, Neil Barrett, Hu Meng, Emanuela Ricciotti, Ciara McDonnell, Andrew Dancis, Julianne Qualtieri, Garret A. FitzGerald, Melanie Cotter, Daria V. Babushok
Publikováno v:
Blood.
Advances in genomic diagnostics hold promise for improved care of rare hematologic diseases. Here, we describe a novel targeted therapeutic approach for Ghosal hematodiaphyseal dysplasia, an autosomal recessive disease characterized by severe normocy