Advances in the Development of Nano-Engineered Mechanically Robust Hydrogels for Minimally Invasive Treatment of Bone Defects

Autor: Kulwinder Kaur, Ciara M. Murphy

Publikováno v: Gels, Vol 9, Iss 10, p 809 (2023)

Injectable hydrogels were discovered as attractive materials for bone tissue engineering applications given their outstanding biocompatibility, high water content, and versatile fabrication platforms into materials with different physiochemical prope

Externí odkaz: https://doaj.org/article/ce8834c31c3742ef9f268e851fe6a8c1

Mechanomodulatory biomaterials prospects in scar prevention and treatment

Autor: Maria G. Fernandes, Lucília P. da Silva, Mariana T. Cerqueira, Rita Ibañez, Ciara M. Murphy, Rui L. Reis, Fergal J. O´Brien, Alexandra P. Marques

Publikováno v: Acta Biomaterialia. 150:22-33

Scarring is a major clinical issue that affects a considerable number of patients. The associated problems go beyond the loss of skin functionality, as scars bring aesthetic, psychological, and social difficulties. Therefore, new strategies are requi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::453b5d1b902bfd4957d849baa37a8e59
https://doi.org/10.1016/j.actbio.2022.07.042

Bisphosphonate-adsorbed ceramic nanoparticles increase bone formation in an injectable carrier for bone tissue engineering

Autor: Tegan L Cheng, Ciara M Murphy, Roya Ravarian, Fariba Dehghani, David G Little, Aaron Schindeler

Publikováno v: Journal of Tissue Engineering, Vol 6 (2015)

Sucrose acetate isobutyrate (SAIB) is a sugar-based carrier. We have previously applied SAIB as a minimally invasive system for the co-delivery of recombinant human bone morphogenetic protein-2 (rhBMP-2) and found synergy when co-delivering zoledroni

Externí odkaz: https://doaj.org/article/240dd5f7b0704a87817c5482d7d46cce

3D-printed gelatin methacrylate scaffolds with controlled architecture and stiffness modulate the fibroblast phenotype towards dermal regeneration

Autor: Fergal J. O'Brien, Alexandra P. Marques, Ronaldo J F C do Amaral, Rita I. R. Ibanez, Ciara M. Murphy, Rui L. Reis

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Polymers
Polymers, Vol 13, Iss 2510, p 2510 (2021)
Volume 13
Issue 15

Impaired skin wound healing due to severe injury often leads to dysfunctional scar tissue formation as a result of excessive and persistent myofibroblast activation, characterised by the increased expression of α-smooth muscle actin (αSMA) and extr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5a60d41072465b6459f12477f11378e

Injectable chitosan/collagen hydrogels nano-engineered with functionalized single wall carbon nanotubes for minimally invasive applications in bone

Autor: David Caffrey, Kulwinder Kaur, Ciara M. Murphy, Silvia Sa' Paiva, Brenton Cavanagh

Publikováno v: Materials Science and Engineering: C. 128:112340

Mechanical robustness is an essential consideration in the development of hydrogel platforms for bone regeneration, and despite significant advances in the field of injectable hydrogels, many fail in this regard. Inspired by the mechanical properties

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edc28deba4f23a393391c3e84719a372
https://doi.org/10.1016/j.msec.2021.112340