Setting course for a translational pharmacology and a predictive toxicology based on the numerical probability of clinical relevance.

Autor: Suarez-Torres JD; Department of Pharmacy, Faculty of Sciences, Universidad Nacional de Colombia, Bogotá D.C., Colombia; Department of Toxicology, Faculty of Medicine, Universidad Nacional de Colombia, Bogotá, D.C., Colombia. Electronic address: jdsuarezto@unal.edu.co., Ciangherotti CE; Laboratory of Neuropeptides. Institute of Pharmaceutical Research, Faculty of Pharmacy, Universidad Central de Venezuela, Caracas, Venezuela., Orozco CA; Department of Animal Health, Faculty of Veterinary Medicine and Zootechnics, Universidad Nacional de Colombia, Bogotá, D.C., Colombia.

Publikováno v: Environmental toxicology and pharmacology [Environ Toxicol Pharmacol] 2023 Jan; Vol. 97, pp. 103968. Date of Electronic Publication: 2022 Sep 06.

Applying Bayesian forecasting to predictive toxicology: The probability of innate carcinogenicity to humans of colorants synthesized from benzidine.

Autor: Suarez-Torres JD; Department of Toxicology (Faculty of Medicine), Department of Pharmacy (Faculty of Sciences). Universidad Nacional de Colombia, Bogotá, D.C., Colombia; Institute of Pharmaceutical Research, Faculty of Pharmacy, Universidad Central de Venezuela, Caracas, D.C., Venezuela. Electronic address: jdsuarezto@unal.edu.co., Orozco CA; Department of Animal Health, Faculty of Veterinary Medicine and Zootechnics, Universidad Nacional de Colombia, Bogotá, D.C, Colombia., Ciangherotti CE; Institute of Pharmaceutical Research, Faculty of Pharmacy, Universidad Central de Venezuela, Caracas, D.C., Venezuela.

Publikováno v: Toxicology letters [Toxicol Lett] 2021 Oct 15; Vol. 351, pp. 111-134. Date of Electronic Publication: 2021 Aug 10.

The 2-year rodent bioassay in drug and chemical carcinogenicity testing: Performance, utility, and configuration for cancer hazard identification.

Autor: Suarez-Torres JD; Department of Pharmacy (Faculty of Sciences), Department of Toxicology (Faculty of Medicine), Universidad Nacional de Colombia, Bogotá, D.C., Colombia; Laboratory of Neuropeptides, Institute of Pharmaceutical Research, Faculty of Pharmacy, Universidad Central de Venezuela, Caracas, Venezuela. Electronic address: jdsuarezto@unal.edu.co., Orozco CA; Department of Animal Health, Faculty of Veterinary Medicine and Zootechnics, Universidad Nacional de Colombia, Bogotá, D.C., Colombia., Ciangherotti CE; Laboratory of Neuropeptides, Institute of Pharmaceutical Research, Faculty of Pharmacy, Universidad Central de Venezuela, Caracas, Venezuela.

Publikováno v: Journal of pharmacological and toxicological methods [J Pharmacol Toxicol Methods] 2021 Jul-Aug; Vol. 110, pp. 107070. Date of Electronic Publication: 2021 Apr 25.

Drug excipients, food additives, and cosmetic ingredients probably not carcinogenic to humans reveal a functional specificity for the 2-year rodent bioassay.

Autor: Suarez-Torres JD; Department of Toxicology, Department of Pharmacy, Universidad Nacional de Colombia, Bogotá, Colombia.; Institute of Pharmaceutical Research, School of Pharmacy, Universidad Central de Venezuela, Caracas, Venezuela., Jimenez-Orozco FA; Department of Pharmacology, Faculty of Medicine, Universidad Nacional Autonoma de Mexico, Ciudad de Mexico, Mexico., Ciangherotti CE; Laboratory of Neuropeptides, School of Pharmacy, Universidad Central de Venezuela, Caracas, Venezuela.

Publikováno v: Journal of applied toxicology : JAT [J Appl Toxicol] 2020 Aug; Vol. 40 (8), pp. 1113-1130. Date of Electronic Publication: 2020 Apr 07.

Insights into toxicology, safety pharmacology, and drug dependence testing: The performance and predictive values of nonclinical tests.

Autor: Suarez-Torres JD; Department of Toxicology, Department of Pharmacy, Universidad Nacional de Colombia, Bogotá, Colombia; Institute of Pharmaceutical Research, School of Pharmacy, Universidad Central de Venezuela, Caracas, Venezuela. Electronic address: jdsuarezto@outlook.com., Ciangherotti CE; Institute of Pharmaceutical Research, School of Pharmacy, Universidad Central de Venezuela, Caracas, Venezuela; Laboratory of Neuropeptides, School of Pharmacy, Universidad Central de Venezuela, Caracas, Venezuela., Jimenez-Orozco FA; Department of Pharmacology, Faculty of Medicine, Universidad Nacional Autónoma de México, Ciudad de México, Mexico.

Publikováno v: Journal of pharmacological and toxicological methods [J Pharmacol Toxicol Methods] 2020 May - Jun; Vol. 103, pp. 106684. Date of Electronic Publication: 2020 Mar 12.