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Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation.

Autor: McAllister LA; Pfizer Worldwide Research and Development , 610 Main Street , Cambridge , Massachusetts 02139 , United States., Butler CR; Pfizer Worldwide Research and Development , 610 Main Street , Cambridge , Massachusetts 02139 , United States., Mente S; Pfizer Worldwide Research and Development , 610 Main Street , Cambridge , Massachusetts 02139 , United States., O'Neil SV; Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States., Fonseca KR; Pfizer Worldwide Research and Development , 610 Main Street , Cambridge , Massachusetts 02139 , United States., Piro JR; Pfizer Worldwide Research and Development , 610 Main Street , Cambridge , Massachusetts 02139 , United States., Cianfrogna JA; Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States., Foley TL; Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States., Gilbert AM; Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States., Harris AR; Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States., Helal CJ; Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States., Johnson DS; Pfizer Worldwide Research and Development , 610 Main Street , Cambridge , Massachusetts 02139 , United States., Montgomery JI; Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States., Nason DM; Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States., Noell S; Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States., Pandit J; Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States., Rogers BN; Pfizer Worldwide Research and Development , 610 Main Street , Cambridge , Massachusetts 02139 , United States., Samad TA; Pfizer Worldwide Research and Development , 610 Main Street , Cambridge , Massachusetts 02139 , United States., Shaffer CL; Pfizer Worldwide Research and Development , 610 Main Street , Cambridge , Massachusetts 02139 , United States., da Silva RG; Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States., Uccello DP; Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States., Webb D; Pfizer Worldwide Research and Development , 610 Main Street , Cambridge , Massachusetts 02139 , United States., Brodney MA; Pfizer Worldwide Research and Development , 610 Main Street , Cambridge , Massachusetts 02139 , United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2018 Apr 12; Vol. 61 (7), pp. 3008-3026. Date of Electronic Publication: 2018 Mar 15.