Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Cian O'Leary"'
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
Introduction: Attempted tracheal replacement efforts thus far have had very little success. Major limiting factors have been the inability to efficiently re-vascularise and mimic the mechanical properties of native tissue. The major objective of this
Externí odkaz:
https://doaj.org/article/aa33168467d04b4ea36e8406a2544676
Targeted Therapies for Kirsten Rat Sarcoma (KRAS) G12C Mutant Metastatic Non-Small-Cell Lung Cancers
Publikováno v:
Cancers, Vol 15, Iss 23, p 5582 (2023)
Non-small-cell lung cancer (NSCLC) is a prevalent and often fatal malignancy. Advancements in targeted therapies have improved outcomes for NSCLC patients in the last decade. Kirsten rat sarcoma virus (KRAS) is a commonly mutated oncogene in NSCLC, c
Externí odkaz:
https://doaj.org/article/61dbf7a4c323437985f77d9f4f507f45
Autor:
Elizabeth Sainsbury, Ronaldo do Amaral, Alexander W. Blayney, Rory McConn Walsh, Fergal J. O'Brien, Cian O'Leary
Publikováno v:
Biomaterials and Biosystems, Vol 6, Iss , Pp 100046- (2022)
Despite the high success rate of autologous grafts in tympanic membrane repair, clinical alternatives are required for the closure of unresponsive chronic perforations that can lead to recurring infection and hearing loss. Tissue engineering and rege
Externí odkaz:
https://doaj.org/article/7ad9e81b2702444bac21e692c196e5c9
Development and clinical translation of tubular constructs for tracheal tissue engineering: a review
Autor:
Luis Soriano, Tehreem Khalid, Derek Whelan, Niall O'Huallachain, Karen C. Redmond, Fergal J. O'Brien, Cian O'Leary, Sally-Ann Cryan
Publikováno v:
European Respiratory Review, Vol 30, Iss 162 (2021)
Effective restoration of extensive tracheal damage arising from cancer, stenosis, infection or congenital abnormalities remains an unmet clinical need in respiratory medicine. The trachea is a 10–11 cm long fibrocartilaginous tube of the lower resp
Externí odkaz:
https://doaj.org/article/97b08629d27c46eaa0083b7ae33eb3e2
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 17, Iss , Pp 591-598 (2019)
Within the past 25 years, tissue engineering (TE) has grown enormously as a science and as an industry. Although classically concerned with the recapitulation of tissue and organ formation in our body for regenerative medicine, the evolution of TE re
Externí odkaz:
https://doaj.org/article/dc66eaa980c94d0caed7cec63641d542
Autor:
Cian O'Leary, Luis Soriano, Aidan Fagan-Murphy, Ivana Ivankovic, Brenton Cavanagh, Fergal J. O'Brien, Sally-Ann Cryan
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
Although relatively rare, major trauma to the tracheal region of the airways poses a significant clinical challenge with few effective treatments. Bioengineering and regenerative medicine strategies have the potential to create biocompatible, implant
Externí odkaz:
https://doaj.org/article/bcaf8e0ff8a44df8a87f446d3ab3ca72
Publikováno v:
Biomedicines, Vol 9, Iss 6, p 631 (2021)
Translation of novel inhalable therapies for respiratory diseases is hampered due to the lack of in vitro cell models that reflect the complexity of native tissue, resulting in many novel drugs and formulations failing to progress beyond preclinical
Externí odkaz:
https://doaj.org/article/7f872e35254148509db1c7f7a14d740e
Autor:
Pasquale Marrazzo, Cian O’Leary
Publikováno v:
Bioengineering, Vol 7, Iss 3, p 104 (2020)
Although a large panel of natural antioxidants demonstrate a protective effect in preventing cellular oxidative stress, their low bioavailability limits therapeutic activity at the targeted injury site. The importance to deliver drug or cells into ox
Externí odkaz:
https://doaj.org/article/9f03fbfb31d3477aa2e2ce27e7df3aa3
Autor:
Alan Hibbitts, Cian O’Leary
Publikováno v:
Materials, Vol 11, Iss 2, p 321 (2018)
In a recent report, the World Health Organisation (WHO) classified antibiotic resistance as one of the greatest threats to global health, food security, and development. Methicillin-resistant Staphylococcus aureus (MRSA) remains at the core of this t
Externí odkaz:
https://doaj.org/article/4fd48f89583d4db180314fba42db34ae
Autor:
Tehreem Khalid, Cian O’Leary
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9783031266249
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f414fabd48eea128444c5f2f32a38c0a
https://doi.org/10.1007/978-3-031-26625-6_7
https://doi.org/10.1007/978-3-031-26625-6_7