Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Cian M. McCrudden"'
Autor:
Davide Schiroli, María J. Gómara, Eleonora Maurizi, Sarah D. Atkinson, Laura Mairs, Kathleen A. Christie, Diego F. Cobice, Cian M. McCrudden, M. Andrew Nesbit, Isabel Haro, Tara Moore
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 17, Iss , Pp 891-906 (2019)
Autosomal dominantly inherited genetic disorders such as corneal dystrophies are amenable to allele-specific gene silencing with small interfering RNA (siRNA). siRNA delivered to the cornea by injection, although effective, is not suitable for a freq
Externí odkaz:
https://doaj.org/article/37a40799393b446e910c2cb79f80cc7c
Autor:
Peng Lyu, Lilin Ge, Rui Ma, Ran Wei, Cian M. McCrudden, Tianbao Chen, Chris Shaw, Hang Fai Kwok
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Abstract Amphibian venom-derived peptides have high potential in the field of anticancer drug discovery. We have isolated a novel Bowman-Birk proteinase inhibitor (BBI)-type peptide from the skin secretion of Pelophylax esculentus (PE) named PE-BBI,
Externí odkaz:
https://doaj.org/article/e47e647ee7894a52aaeccaa734ca8ee8
Autor:
Cian M. McCrudden, John W. McBride, Joanne McCaffrey, Emma M. McErlean, Nicholas J. Dunne, Vicky L. Kett, Jonathan A. Coulter, Tracy Robson, Helen O. McCarthy
Publikováno v:
Cancer Nanotechnology, Vol 9, Iss 1, Pp 1-15 (2018)
Abstract Background Recent approvals of gene therapies by the FDA and the EMA for treatment of inherited disorders have further opened the door for assessment of nucleic acid pharmaceuticals for clinical usage. Arising from the presence of damaged or
Externí odkaz:
https://doaj.org/article/9ed2bf465afb41bba08a79b15b46f23a
Autor:
Ravikiran Mahadevappa, Henrique Neves, Shun Ming Yuen, Yuchen Bai, Cian M. McCrudden, Hiu Fung Yuen, Qing Wen, Shu Dong Zhang, Hang Fai Kwok
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract DNA replication is a critical step in cell proliferation. Overexpression of MCM2-7 genes correlated with poor prognosis in breast cancer patients. However, the roles of Cdc6 and Cdt1, which work with MCMs to regulate DNA replication, in brea
Externí odkaz:
https://doaj.org/article/5d67ca260d2d4a3ba651bf96ea3d89ef
Autor:
Cian M. McCrudden, John W. McBride, Joanne McCaffrey, Ahlam A. Ali, Nicholas J. Dunne, Vicky L. Kett, Jonathan A. Coulter, Tracy Robson, Helen O. McCarthy
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 6, Iss , Pp 249-258 (2017)
This study aimed to determine the therapeutic benefit of a nanoparticular formulation for the delivery of inducible nitric oxide synthase (iNOS) gene therapy in a model of breast cancer metastasis. Nanoparticles comprising a cationic peptide vector,
Externí odkaz:
https://doaj.org/article/6e5a1d3407dd4a3ab97c5e21c1d9b806
Autor:
Grace Cole, Joanne McCaffrey, Ahlam A. Ali, John W. McBride, Cian M. McCrudden, Eva M. Vincente-Perez, Ryan F. Donnelly, Helen O. McCarthy
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 13, Iss 1, Pp 50-62 (2017)
DNA vaccination holds the potential to treat or prevent nearly any immunogenic disease, including cancer. To date, these vaccines have demonstrated limited immunogenicity in vivo due to the absence of a suitable delivery system which can protect DNA
Externí odkaz:
https://doaj.org/article/34001c2764484bf090f282e497651d6e
Autor:
Ian J. Stratford, Stephen R. Wedge, Mark J. O'Connor, David G. Hirst, Cian M. McCrudden, Kim E. Cherry, Brian A. Telfer, Joana M. Senra
PDF file - 491K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1042a9f1e83738cbd73bc9d740c74824
https://doi.org/10.1158/1535-7163.22497210.v1
https://doi.org/10.1158/1535-7163.22497210.v1
Autor:
Eoghan J. Mulholland, Monika Ziminska, Tracy Robson, Grace Cole, Vicky L. Kett, Helen O. McCarthy, Emma M. McErlean, Nicholas Dunne, Cian M. McCrudden, Niamh E. Buckley, John W. McBride, Stephen P. Loughran
Publikováno v:
McErlean, E M, Ziminska, M, McCrudden, C M, McBride, J W, Loughran, S P, Cole, G, Mulholland, E J, Kett, V, Buckley, N E, Robson, T, Dunne, N J & McCarthy, H O 2020, ' Rational design and characterisation of a linear cell penetrating peptide for non-viral gene delivery ', Journal of Controlled Release, vol. 330, pp. 1288 . https://doi.org/10.1016/j.jconrel.2020.11.037
The design of a non-viral gene delivery system that can release a functional nucleic acid at the intracellular destination site is an exciting but also challenging proposition. The ideal gene delivery vector must be non-toxic, non-immunogenic, overco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f03a6e561e7b2be5887b475b411cf9e
https://doi.org/10.1016/j.jconrel.2020.11.037
https://doi.org/10.1016/j.jconrel.2020.11.037
Autor:
Cian M. McCrudden, Emma M. McErlean, Ryan F. Donnelly, Vicky L. Kett, Tracy Robson, Amy Short, Ahlam A. Ali, Joanne McCaffrey, Grace Cole, Eoghan J. Mulholland, Helen O. McCarthy, Nicholas Dunne, Jonathan A. Coulter
Publikováno v:
Cole, G, Ali, A A, McErlean, E, Mulholland, E J, Short, A, McCrudden, C M, McCaffrey, J, Robson, T, Kett, V L, Coulter, J A, Dunne, N J, Donnelly, R F & McCarthy, H O 2019, ' DNA vaccination via RALA nanoparticles in a microneedle delivery system induces a potent immune response against the endogenous prostate cancer stem cell antigen ', Acta Biomaterialia, vol. 96, pp. 480 . https://doi.org/10.1016/j.actbio.2019.07.003
Castrate resistant prostate cancer (CRPC) remains a major challenge for healthcare professionals. Immunotherapeutic approaches, including DNA vaccination, hold the potential to harness the host's own immune system to mount a cell-mediated, anti-tumou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e07b42cca780169c2d602a665e4ce2e
https://doi.org/10.1016/j.actbio.2019.07.003
https://doi.org/10.1016/j.actbio.2019.07.003
Autor:
Nicholas Dunne, Vicky L. Kett, Emma M. McErlean, John W. McBride, Helen O. McCarthy, Grace Cole, Tracy Robson, Cian M. McCrudden
Publikováno v:
McErlean, E M, McCrudden, C M, McBride, J W, Cole, G, Kett, V L, Robson, T, Dunne, N J & McCarthy, H O 2021, ' Rational design and characterisation of an amphipathic cell penetrating peptide for non-viral gene delivery ', International Journal of Pharmaceutics, vol. 596, 120223 . https://doi.org/10.1016/j.ijpharm.2021.120223
RALA is a cationic amphipathic peptide which has shown great promise as an efficient, multifunctional delivery system for the delivery of nucleic acids. Rational peptide design was utilised in this study to understand the essential amino acids requir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::310944210b5710bbba2c12c7f036ad05
https://pure.qub.ac.uk/en/publications/5c53cc9b-589a-4890-9376-eff2d5754056
https://pure.qub.ac.uk/en/publications/5c53cc9b-589a-4890-9376-eff2d5754056