Výsledky vyhledávání - "Cian Glenfield"

Supplementary Figure S6 from Maturation Stage of T-cell Acute Lymphoblastic Leukemia Determines BCL-2 versus BCL-XL Dependence and Sensitivity to ABT-199

Autor: Anthony Letai, Michelle A. Kelliher, Alejandro Gutierrez, Marian Harris, Richard Stone, Daniel J. DeAngelo, Brent Wood, Stephen P. Hunger, Mignon L. Loh, Lewis B. Silverman, Stephen E. Sallan, Jeremy Ryan, Cian Glenfield, Justine E. Roderick, Triona Ni Chonghaile

NSG mice were injected in the tail with either ETP-ALL (TALL-x-11) or typical T-ALL (TALL-x-2) 1X106 cells and following engraftment to 65% the mice were randomized to receive vehicle, ABT-199 or ABT-263 treatment for two-weeks. The spleen weights (A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::420fd463af5ed6dbbe884834272bae70
https://doi.org/10.1158/2159-8290.22531948.v1

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Supplementary Figure S3 from Maturation Stage of T-cell Acute Lymphoblastic Leukemia Determines BCL-2 versus BCL-XL Dependence and Sensitivity to ABT-199

Flow cytometry gating strategy to identify the early progenitor cells using CD44 and CD25 antibodies on the double negative CD4-/CD8- gate. BCL-2 expression and BCL-XL expression was measured on each of the gated regions listed.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3498a13a272d1aa61d04e63ce3b88028
https://doi.org/10.1158/2159-8290.22531957.v1

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Supplementary Figure S2 from Maturation Stage of T-cell Acute Lymphoblastic Leukemia Determines BCL-2 versus BCL-XL Dependence and Sensitivity to ABT-199

The percentage of cells expressing CD8 is shown for both ETP-ALL and for Typical T-ALL primary human samples. The data is modified from the published online dataset (2). The majority of typical T-ALL samples are positive for CD8 expression by flow cy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4172d8b450cd4e1ae5b3ec7217241bfb
https://doi.org/10.1158/2159-8290.22531960.v1

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Supplementary Figure S5 from Maturation Stage of T-cell Acute Lymphoblastic Leukemia Determines BCL-2 versus BCL-XL Dependence and Sensitivity to ABT-199

Primary T-ALL samples were treated for six hours in short term culture with both ABT-199 and ABT-263. Apoptosis was assesed by Annexin V and Propidium Iodide staining. The calculated IC50 in μM is listed beside each of the BH3 mimetics.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e19bb80f3a748c4ed5963563696b492d
https://doi.org/10.1158/2159-8290.22531951.v1

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Supplementary Figure S1 from Maturation Stage of T-cell Acute Lymphoblastic Leukemia Determines BCL-2 versus BCL-XL Dependence and Sensitivity to ABT-199

T-cell ALL cell lines were treated for 48hr with five doses of ABT-199 and ABT-263. Apoptosis was assessed by Annexin V and Propidium Iodide (PI) staining. The mean % viability of three independent experiments is graphed +/- standard error. The calcu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dfb9b6937a0348de4c36a000bc9c5c1
https://doi.org/10.1158/2159-8290.22531963.v1

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Gene Duplication and Gene Fusion Are Important Drivers of Tumourigenesis during Cancer Evolution

Autor: Hideki Innan, Cian Glenfield

Publikováno v: Genes
Genes, Vol 12, Iss 1376, p 1376 (2021)

Chromosomal rearrangement and genome instability are common features of cancer cells in human. Consequently, gene duplication and gene fusion events are frequently observed in human malignancies and many of the products of these events are pathogenic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb7b71094f6ece48b447cb55439ec167
http://europepmc.org/articles/PMC8466788

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Pseudogenes Provide Evolutionary Evidence for the Competitive Endogenous RNA Hypothesis

Autor: Aoife McLysaght, Cian Glenfield

Publikováno v: Molecular Biology and Evolution

The competitive endogenous RNA (ceRNA) hypothesis is an attractively simple model to explain the biological role of many putatively functionless noncoding RNAs. Under this model, there exist transcripts in the cell whose role is to titrate out microR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11adc9331f6154199ed1e87ae0b6b8fb
http://europepmc.org/articles/PMC6278865

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Maturation Stage of T-cell Acute Lymphoblastic Leukemia Determines BCL-2 versus BCL-XL Dependence and Sensitivity to ABT-199

Autor: Mignon L. Loh, Lewis B. Silverman, Michelle A. Kelliher, Daniel J. DeAngelo, Brent L. Wood, Richard Stone, Triona Ni Chonghaile, Cian Glenfield, Marian H. Harris, Justine E. Roderick, Anthony Letai, Jeremy Ryan, Stephen P. Hunger, Stephen E. Sallan, Alejandro Gutierrez

Publikováno v: Cancer Discovery. 4:1074-1087

Acute lymphoblastic leukemia (ALL) is a hematopoietic malignancy derived from immature B-lymphoid and T-lymphoid cells (T-ALL). In T-ALL, there is an early T-cell progenitor (ETP) subgroup that has a very high risk for relapse. In this study, we used

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1347ac04d0a913c3f9612c330a28894a
https://doi.org/10.1158/2159-8290.cd-14-0353

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