Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Cia-Hin Lau"'
Autor:
Zhongqi Zhou, Cia-Hin Lau, Jianchao Wang, Rui Guo, Sheng Tong, Jiaqi Li, Wenjiao Dong, Zhihao Huang, Tao Wang, Xiaojun Huang, Ziqing Yu, Chiju Wei, Gang Chen, Hongman Xue, Haibao Zhu
Publikováno v:
ACS Omega, Vol 9, Iss 26, Pp 28866-28878 (2024)
Externí odkaz:
https://doaj.org/article/a3760918693e47ce99201c85581d99e6
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 26, Iss , Pp 26-37 (2022)
VP64 is the smallest transactivation domain that can be packaged together with the sgRNA into a single adeno-associated virus (AAV) vector. However, VP64-based CRISPRa often exerts modest activation to the target gene when only one sgRNA is used. Her
Externí odkaz:
https://doaj.org/article/39fc018d7551402287c6bae071c43261
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 16, Iss , Pp 637-649 (2019)
Targeted transcriptional modulation in the central nervous system (CNS) can be achieved by adeno-associated virus (AAV) delivery of CRISPR activation (CRISPRa) and interference (CRISPRi) transgenes. To enable AAV packaging, we constructed minimal CRI
Externí odkaz:
https://doaj.org/article/b1d286e24d6e495698add00b024156a0
Autor:
Cia-Hin Lau, Yousin Suh
Publikováno v:
F1000Research, Vol 6 (2017)
Adeno-associated virus (AAV) has shown promising therapeutic efficacy with a good safety profile in a wide range of animal models and human clinical trials. With the advent of clustered regulatory interspaced short palindromic repeat (CRISPR)-based g
Externí odkaz:
https://doaj.org/article/691385ca02c6425daeb3779339606fc8
Autor:
Cia-Hin Lau, Sekaran Muniandy
Publikováno v:
Genetics and Molecular Biology, Vol 35, Iss 1, Pp 38-44 (2012)
Epistasis (gene-gene interaction) is a ubiquitous component of the genetic architecture of complex traits such as susceptibility to common human diseases. Given the strong negative correlation between circulating adiponectin and resistin levels, the
Externí odkaz:
https://doaj.org/article/0183167b0b4c4581ac1b407d00470173
Autor:
Cia-Hin Lau, Haibao Zhu, Johan Chin-Kang Tay, Zhendong Li, Felix Chang Tay, Can Chen, Wee-Kiat Tan, Shouhui Du, Vic-Ki Sia, Rui-Zhe Phang, Shin-Yi Tang, Chiyun Yang, Zhixia Chi, Chieh-Ching Liang, Er Ning, Shu Wang
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 1, Iss C (2014)
Virus-derived gene transfer vectors have been successfully employed to express the transcription activator-like effector nucleases (TALENs) in mammalian cells. Since the DNA-binding domains of TALENs consist of the variable di-residue (RVD)-containin
Externí odkaz:
https://doaj.org/article/e48b6d5d34f54c6fb140bc6cf98feafe
Autor:
Fei Wang, Ling Sum Liu, Pan Li, Cia Hin Lau, Hoi Man Leung, Y Rebecca Chin, Chung Tin, Pik Kwan Lo
Publikováno v:
Materials Today Bio, Vol 15, Iss , Pp 100299- (2022)
Compared with siRNAs or other antisense oligonucleotides (ASOs), the chemical simplicity, DNA/RNA binding capability, folding ability of tertiary structure, and excellent physiological stability of threose nucleic acid (TNA) motivate scientists to ex
Externí odkaz:
https://doaj.org/article/9bf1498ca33a40259d59fc8e02323968
Publikováno v:
Molecular Therapy - Methods & Clinical Development. 26:26-37
VP64 is the smallest transactivation domain that can be packaged together with the sgRNA into a single adeno-associated virus (AAV) vector. However, VP64-based CRISPRa often exerts modest activation to the target gene when only one sgRNA is used. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b54b83613580e0a63ed5c9c369e07ba
https://doi.org/10.1016/j.omtm.2022.05.005
https://doi.org/10.1016/j.omtm.2022.05.005
Publikováno v:
Biosensorsbioelectronics. 220
Flap endonuclease 1 (FEN1) is an endonuclease that specially removes 5' single-stranded overhang of branched duplex DNA (5' flap). While FEN1 is essential in various DNA metabolism pathways for preventing the malignant transformation of cells, an unu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eb683957c17bca7c36fc5693db89061
https://pubmed.ncbi.nlm.nih.gov/36368142
https://pubmed.ncbi.nlm.nih.gov/36368142
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7cb46f471e423d4f56b2791b5cc491da
https://doi.org/10.2139/ssrn.4110833
https://doi.org/10.2139/ssrn.4110833