Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Ci-Di Chen"'
Autor:
Ci-Di Chen, Yuexuan Li, Arthur K Chen, Melissa A Rudy, Jason S Nasse, Ella Zeldich, Taryn J Polanco, Carmela R Abraham
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0226382 (2020)
Klotho is an age-extending, cognition-enhancing protein found to be down-regulated in aged mammals when age-related diseases start to appear. Low levels of Klotho occur in neurodegenerative diseases, kidney disease and many cancers. Many normal and p
Externí odkaz:
https://doaj.org/article/4bfff10d5b234cd68fb0ae137b1cc0f3
Autor:
Saverio Bellusci, Kenneth S. Kosik, Giovanni Coppola, Mohsen Ghanbari, Deborah Kim, Israel Hernandez, Kerstin Goth, Brent L. Fogel, Kathie J. Ngo, M. Arfan Ikram, Steven A. Kushner, Ci-Di Chen, Jason D Hinman, Riki Kawaguchi, Carmela R. Abraham
Publikováno v:
Hum Mol Genet
Human molecular genetics, vol 30, iss 1
Human Molecular Genetics, 30(1), 103-118. Oxford University Press
Human molecular genetics, vol 30, iss 1
Human Molecular Genetics, 30(1), 103-118. Oxford University Press
Oligodendrocytes exist in a heterogenous state and are implicated in multiple neuropsychiatric diseases including dementia. Cortical oligodendrocytes are a glial population uniquely positioned to play a key role in neurodegeneration by synchronizing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b40ac2473bf3856e566832b2c1167d33
https://doi.org/10.1093/hmg/ddaa252
https://doi.org/10.1093/hmg/ddaa252
Autor:
Nelson C. Lau, Bryce Howat, Anthony G. Lambert, Theo Hatzipetros, Ann C. McKee, Qicheng Ma, Ci-Di Chen, Dean Zeldich, Emma Boden, Ella Zeldich, Carmela R. Abraham, Jason S. Nasse, Jonathan D. Cherry, Rebecca M. Mathias, Andrea Yuste
Publikováno v:
Journal of Molecular Neuroscience. 69:264-285
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by the loss of motor neurons in the brain and spinal cord. ALS neuropathology is associated with increased oxidative stress, excitotoxicity, and inflammatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb7a3a07ad1a089f894311907c475f99
https://doi.org/10.1007/s12031-019-01356-2
https://doi.org/10.1007/s12031-019-01356-2
Autor:
Jaclyn Garza Grenier, Dana Fein-Schaffer, Zhenwei Zhou, Erika J. Wolf, Annjanette Stone, Ci-Di Chen, Bertrand R. Huber, Filomene G. Morrison, Nikolaos P. Daskalakis, Mark W. Logue, Xiang Zhao, Steven A. Schichman, Carmela R. Abraham, Mark W. Miller
Publikováno v:
Neuropsychopharmacology
This study examined the klotho (KL) longevity gene polymorphism rs9315202 and psychopathology, including posttraumatic stress disorder (PTSD), depression, and alcohol-use disorders, in association with advanced epigenetic age in three postmortem cort
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2dbaae959f2b48306a08336b225df10
https://pubmed.ncbi.nlm.nih.gov/33096543
https://pubmed.ncbi.nlm.nih.gov/33096543
Publikováno v:
FASEB J
There is an unmet need for treatments for diseases associated with aging. The anti-aging, life-extending and cognition-enhancing protein Klotho is neuroprotective due to its anti-inflammatory, anti-oxidative and pro-myelinating effects. In addition,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf5b7f01890414be6e6d9d6f563abb2f
https://pubmed.ncbi.nlm.nih.gov/32347987
https://pubmed.ncbi.nlm.nih.gov/32347987
Autor:
Melissa A. Rudy, Carmela R. Abraham, Taryn J. Polanco, Ci-Di Chen, Arthur K Chen, Yuexuan Li, Ella Zeldich, Jason S. Nasse
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0226382 (2020)
PLoS ONE
PLoS ONE
Klotho is an age-extending, cognition-enhancing protein found to be down-regulated in aged mammals when age-related diseases start to appear. Low levels of Klotho occur in neurodegenerative diseases, kidney disease and many cancers. Many normal and p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f323a8f456dcbcec3eb87b34d1d9d7a3
https://doaj.org/article/4bfff10d5b234cd68fb0ae137b1cc0f3
https://doaj.org/article/4bfff10d5b234cd68fb0ae137b1cc0f3
Autor:
Ella Zeldich, Annina M. DeLeo, Carmela R. Abraham, Lindsay A. Farrer, Nicholas M. Kanaan, M. Daniele Fallin, Ci-Di Chen, Tsuneya Ikezu, Mark W. Logue, Kathryn L. Lunetta
Publikováno v:
Journal of Neuroimmune Pharmacology
We studied the effect of two rare mutations (rs144662445 and rs149979685) in the A-kinase anchoring protein 9 (AKAP9) gene, previously associated with Alzheimer disease (AD) in African Americans (AA), on post-translational modifications of AD-related
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e039d7cc20e5bd5f6742b3fadd977bf4
https://doi.org/10.1007/s11481-018-9781-x
https://doi.org/10.1007/s11481-018-9781-x
Publikováno v:
Journal of Molecular Neuroscience. 64:175-184
Multiple lines of evidence show that the anti-aging and cognition-enhancing protein Klotho fosters neuronal survival, increases the anti-oxidative stress defense, and promotes remyelination of demyelinated axons. Thus, upregulation of the Klotho gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e3d99481b609d77424e465aeb4dff48
https://doi.org/10.1007/s12031-017-1011-0
https://doi.org/10.1007/s12031-017-1011-0
Autor:
Ella, Zeldich, Ci-Di, Chen, Emma, Boden, Bryce, Howat, Jason S, Nasse, Dean, Zeldich, Anthony G, Lambert, Andrea, Yuste, Jonathan D, Cherry, Rebecca M, Mathias, Qicheng, Ma, Nelson C, Lau, Ann C, McKee, Theo, Hatzipetros, Carmela R, Abraham
Publikováno v:
Journal of molecular neuroscience : MN. 69(2)
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by the loss of motor neurons in the brain and spinal cord. ALS neuropathology is associated with increased oxidative stress, excitotoxicity, and inflammatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d42c49a63afc52d88c3abf6bb6ea7a91
https://pubmed.ncbi.nlm.nih.gov/31250273
https://pubmed.ncbi.nlm.nih.gov/31250273
Autor:
Patrick Mullen, Emma C. Lauder, Tze Yu Tung, Yen Yu Liu, William E. Van Nostrand, Kaddy Camara, Carmela R. Abraham, Lauren E. Brown, Ella Zeldich, Taryn J. Polanco, Christina E Khodr, Dean Zeldich, Weiming Xia, John A. Porco, Ci-Di Chen
Alzheimer's disease (AD) is characterized by the accumulation of neurotoxic amyloid-β (Aβ) peptides consisting of 39-43 amino acids, proteolytically derived fragments of the amyloid-β protein precursor (AβPP), and the accumulation of the hyperpho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d924daba487190577cb5ed8f667bd04
https://europepmc.org/articles/PMC6474660/
https://europepmc.org/articles/PMC6474660/
