Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Ci Ji Lim"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Air-water interface (AWI) interactions during cryo-electron microscopy (cryo-EM) sample preparation cause significant sample loss, hindering structural biology research. Organisms like nematodes and tardigrades produce Late Embryogenesis Abu
Externí odkaz:
https://doaj.org/article/c996afbf745e4f528a8c07adb93ed50d
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
The human shelterin complex protects telomere ends from being recognized as damaged DNA sites and regulates telomere length in conjunction with telomerase. Here the authors establish the stoichiometries of human shelterin complexes of various composi
Externí odkaz:
https://doaj.org/article/90c4dc3412f446f394369937d6da4c33
Autor:
Qixiang He, Andrey G. Baranovskiy, Lucia M. Morstadt, Alisa E. Lisova, Nigar D. Babayeva, Benjamin L. Lusk, Ci Ji Lim, Tahir H. Tahirov
Publikováno v:
Nature Structural & Molecular Biology. 30:579-583
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96194c6f01d3b9234775cc98c2c2750f
https://doi.org/10.1038/s41594-023-00971-3
https://doi.org/10.1038/s41594-023-00971-3
Publikováno v:
Nature
The mammalian DNA polymerase-α–primase (Polα–primase) complex is essential for DNA metabolism, providing the de novo RNA–DNA primer for several DNA replication pathways(1–4) such as lagging-strand synthesis and telomere C-strand fill-in. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cafa3ccac3314029285055f4e563b24f
https://doi.org/10.1038/s41586-022-05040-1
https://doi.org/10.1038/s41586-022-05040-1
Autor:
Ci Ji Lim, Qixiang He, Andrey Baranovskiy, Lucia Morstadt, Alisa Lisova, Nigar Babayeva, Benjamin Lusk, Tahir Tahirov
The synthesis of RNA-DNA primer by primosome requires coordination between primase and DNA polymerase α subunits, which is accompanied by unknown architectural rearrangements of multiple domains. Using cryogenic-electron microscope, we solved a 3.6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e0c8182f985933726076aef78c1ae0f
https://doi.org/10.21203/rs.3.rs-1650573/v1
https://doi.org/10.21203/rs.3.rs-1650573/v1
Publikováno v:
Journal of Biological Chemistry. 299:103463
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f304527f0799af6bb8853e91faca529c
https://doi.org/10.1016/j.jbc.2023.103463
https://doi.org/10.1016/j.jbc.2023.103463
Publikováno v:
Journal of Biological Chemistry. 299:103468
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc754f876d9f80cf0cd4d0d8ba80646e
https://doi.org/10.1016/j.jbc.2023.103468
https://doi.org/10.1016/j.jbc.2023.103468
Telomere replication and regulation protect mammalian chromosome ends and promote genome stability. An essential step in telomere maintenance is the C-strand fill-in process, which is the de novo synthesis of the complementary strand of the telomere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dcfc962d5acf06fac5a74ca03ff97cf3
https://doi.org/10.1101/2021.12.16.472968
https://doi.org/10.1101/2021.12.16.472968
Autor:
Conner L. Olson, Ci Ji Lim, Arthur J. Zaug, Karen J. Goodrich, Deborah S. Wuttke, Thomas R. Cech, Maria T. Carilli
Publikováno v:
Nucleic Acids Research
The CST complex (CTC1-STN1-TEN1) has been shown to inhibit telomerase extension of the G-strand of telomeres and facilitate the switch to C-strand synthesis by DNA polymerase alpha-primase (pol α-primase). Recently the structure of human CST was sol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08b8a1bd6dff0602c46f867ae26afea4
https://pubmed.ncbi.nlm.nih.gov/34718732
https://pubmed.ncbi.nlm.nih.gov/34718732
Autor:
Ci Ji Lim, Alexandra Barbour, Arthur Zaug, Karen Goodrich, Allison McKay, Deborah Wuttke, Thomas R. Cech
Publikováno v:
Biophysical Journal. 121:1a-2a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19185828eda2f38127a3bcdebb27f705
https://doi.org/10.1016/j.bpj.2021.11.2698
https://doi.org/10.1016/j.bpj.2021.11.2698