Zobrazeno 1 - 10
of 133
pro vyhledávání: '"Chyuan Sheng Lin"'
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-19 (2024)
Abstract Background Recent experimental studies of neuroinflammation in glaucoma pointed to cFLIP as a molecular switch for cell fate decisions, mainly regulating cell type-specific caspase-8 functions in cell death and inflammation. This study aimed
Externí odkaz:
https://doaj.org/article/898c58d6393d4678b4a15463d1028d07
Autor:
Nan-Kai Wang, Pei-Kang Liu, Yang Kong, Yun-Ju Tseng, Laura A. Jenny, Nicholas D. Nolan, Nelson Chen, Hung-Hsi Wang, Chun Wei Hsu, Wan-Chun Huang, Janet R. Sparrow, Chyuan-Sheng Lin, Stephen H. Tsang
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-19 (2023)
Abstract Background Cones are essential for color recognition, high resolution, and central vision; therefore cone death causes blindness. Understanding the pathophysiology of each cell type in the retina is key to developing therapies for retinal di
Externí odkaz:
https://doaj.org/article/f06c541ff511434ab196ba88974fd001
Autor:
Akihiro Miura, Hemanta Sarmah, Junichi Tanaka, Youngmin Hwang, Anri Sawada, Yuko Shimamura, Takehiro Otoshi, Yuri Kondo, Yinshan Fang, Dai Shimizu, Zurab Ninish, Jake Le Suer, Nicole C Dubois, Jennifer Davis, Shinichi Toyooka, Jun Wu, Jianwen Que, Finn J Hawkins, Chyuan-Sheng Lin, Munemasa Mori
Publikováno v:
eLife, Vol 12 (2023)
Millions suffer from incurable lung diseases, and the donor lung shortage hampers organ transplants. Generating the whole organ in conjunction with the thymus is a significant milestone for organ transplantation because the thymus is the central orga
Externí odkaz:
https://doaj.org/article/5cf0469dedb0467cb9d40502533f7091
Autor:
Foon Wu-Baer, Madeline Wong, Lydia Tschoe, Chyuan-Sheng Lin, Wenxia Jiang, Shan Zha, Richard Baer
Publikováno v:
Cells, Vol 12, Iss 23, p 2762 (2023)
Homology-directed repair (HDR) of double-strand DNA breaks (DSBs) is dependent on enzymatic resection of DNA ends by the Mre11/Rad50/Nbs1 complex. DNA resection is triggered by the CtIP/Sae2 protein, which allosterically promotes Mre11-mediated endon
Externí odkaz:
https://doaj.org/article/c46c1a5ffbd044fd934042040320e8b2
Autor:
Na Luo, Ioanna Mosialou, Mattia Capulli, Brygida Bisikirska, Chyuan-Sheng Lin, Yung-yu Huang, Peter T. Shyu, X. Edward Guo, Aris Economides, J. John Mann, Stavroula Kousteni
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 23 (2022)
The various functions of the skeleton are influenced by extracellular cues, hormones, and neurotransmitters. One type of neuronal regulation favors bone mass accrual by inhibiting sympathetic nervous system (SNS) activity. This observation raises que
Externí odkaz:
https://doaj.org/article/b9e861080b4a4c4f82712f46ce3a089e
Autor:
Tiffany Tate, Tina Xiang, Sarah E. Wobker, Mi Zhou, Xiao Chen, Hyunwoo Kim, Ekatherina Batourina, Chyuan-Sheng Lin, William Y. Kim, Chao Lu, James M. Mckiernan, Cathy Lee Mendelsohn
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
PPARg is differentially expressed in bladder cancer subtypes. Here, the authors show in mice that when an activated form of PPARg is expressed in basal bladder cells tumours do not form, however in the presence of injury the basal cells differentiate
Externí odkaz:
https://doaj.org/article/458eca01a6e54249ad6eb5780e7e2e46
Autor:
Tian Huai Shen, Jacob Stauber, Katherine Xu, Alexandra Jacunski, Neal Paragas, Miriam Callahan, Run Banlengchit, Abraham D. Levitman, Beatriz Desanti De Oliveira, Andrew Beenken, Madeleine S. Grau, Edwin Mathieu, Qingyin Zhang, Yuanji Li, Tejashree Gopal, Nathaniel Askanase, Siddarth Arumugam, Sumit Mohan, Pamela I. Good, Jacob S. Stevens, Fangming Lin, Samuel K. Sia, Chyuan-Sheng Lin, Vivette D’Agati, Krzysztof Kiryluk, Nicholas P. Tatonetti, Jonathan Barasch
Publikováno v:
JCI Insight, Vol 7, Iss 6 (2022)
The current strategy to detect acute injury of kidney tubular cells relies on changes in serum levels of creatinine. Yet serum creatinine (sCr) is a marker of both functional and pathological processes and does not adequately assay tubular injury. In
Externí odkaz:
https://doaj.org/article/d9fba6cf58ab4e01a1803b5c7438fa55
Autor:
Kumi Morikawa, Kazuhiro Furuhashi, Carmen de Sena-Tomas, Alvaro L. Garcia-Garcia, Ramsey Bekdash, Alison D. Klein, Nicholas Gallerani, Hannah E. Yamamoto, Seon-Hye E. Park, Grant S. Collins, Fuun Kawano, Moritoshi Sato, Chyuan-Sheng Lin, Kimara L. Targoff, Edmund Au, Michael C. Salling, Masayuki Yazawa
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Previous versions of photoactivatable Cre recombinase (PA-Cre) suffered from unintentional recombination in dark conditions. Here, the authors develop an improved version of PA-Cre, called PA-Cre 3.0, which shows reduced leakiness and improved effici
Externí odkaz:
https://doaj.org/article/4dd05e1b2991499aa94c1548679f42b6
Autor:
Nan-Kai Wang, Pei-Kang Liu, Yang Kong, Sarah R. Levi, Wan-Chun Huang, Chun-Wei Hsu, Hung-Hsi Wang, Nelson Chen, Yun-Ju Tseng, Peter M. J. Quinn, Ming-Hong Tai, Chyuan-Sheng Lin, Stephen H. Tsang
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 15, p 8069 (2021)
Achromatopsia is characterized by amblyopia, photophobia, nystagmus, and color blindness. Previous animal models of achromatopsia have shown promising results using gene augmentation to restore cone function. However, the optimal therapeutic window t
Externí odkaz:
https://doaj.org/article/3c10acec8d8b4a0d8a3afcfd49a4236d
Autor:
Xuan Cui, Hye Jin Kim, Chia-Hua Cheng, Laura A Jenny, Jose Ronaldo Lima de Carvalho, Ya-Ju Chang, Yang Kong, Chun-Wei Hsu, I-Wen Huang, Sara D Ragi, Chyuan-Sheng Lin, Xiaorong Li, Janet R Sparrow, Stephen H Tsang
Publikováno v:
Hum Mol Genet
Retinitis pigmentosa (RP) is caused by one of many possible gene mutations. The National Institutes of Health recommends high daily doses of vitamin A palmitate for RP patients. There is a critical knowledge gap surrounding the therapeutic applicabil