Zobrazeno 1 - 10
of 168
pro vyhledávání: '"Chyng-Yann Shiue"'
Autor:
Chi-Wei Chang, Chuang-Hsin Chiu, Ming-Hsien Lin, Hung-Ming Wu, Tsung-Hsun Yu, Pao-Yeh Wang, Yu-Yeh Kuo, Ya-Yao Huang, Chyng-Yann Shiue, Wen-Sheng Huang, Skye Hsin-Hsien Yeh
Publikováno v:
EJNMMI Research, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Background Expression of translocator protein (TSPO) on the outer mitochondrial membrane of activated microglia is strongly associated with neuroinflammation. The second-generation PET ligand [18F]FEPPA specifically binds TSPO to enable in v
Externí odkaz:
https://doaj.org/article/02c553ee31dd4096a40e7014f15614f1
Autor:
Mei-Fang Cheng, Tsun-Jen Cheng, Yue Leon Guo, Ching-Hung Chiu, Hung-Ming Wu, Ruoh-Fang Yen, Ya-Yao Huang, Wen-Sheng Huang, Chyng-Yann Shiue
Publikováno v:
Molecular Imaging, Vol 2022 (2022)
Background. [18F]FEPPA is a potent TSPO imaging agent that has been found to be a potential tracer for imaging neuroinflammation. In order to fulfill the demand of this tracer for preclinical and clinical studies, we have developed a one-pot automate
Externí odkaz:
https://doaj.org/article/a3af1e1d75a44beda9650a0a84f7d55c
Autor:
Wen-Sheng Huang, Guann-Juh Chen, Tung-Han Tsai, Chen-Yi Cheng, Chyng-Yann Shiue, Kuo-Hsing Ma, Skye Hsin-Hsien Yeh
Publikováno v:
EJNMMI Research, Vol 9, Iss 1, Pp 1-10 (2019)
Abstract Background Methamphetamine (METH)-associated alterations in the striatal dopamine (DA) system or dopamine transport (DAT) have been identified in clinical and preclinical studies with positron emission tomography (PET) imaging but have not b
Externí odkaz:
https://doaj.org/article/e1f5353319314e2d9c22a88a0469d9a2
Autor:
Kai-Ting Shih, Ya-Yao Huang, Chia-Ying Yang, Mei-Fang Cheng, Yu-Wen Tien, Chyng-Yann Shiue, Rouh-Fang Yen, Ling-Wei Hsin
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0243831 (2020)
(4S)-4-(3-[18F]Fluoropropyl)-L-glutamic acid ([18F]FSPG) is a positron emission tomography (PET) imaging agent for measuring the system xC- transporter activity. It has been used for the detection of various cancers and metastasis in clinical trials.
Externí odkaz:
https://doaj.org/article/20e51eae62e743ed9a64eba91d0a1537
Autor:
Li-Fan Lin, Yun-Ting Jhao, Chuang-Hsin Chiu, Lu-Han Sun, Ta-Kai Chou, Chyng-Yann Shiue, Cheng-Yi Cheng, Kuo-Hsing Ma
Publikováno v:
Pharmaceuticals, Vol 15, Iss 2, p 109 (2022)
Bezafibrate, a pan-peroxisome proliferator-activated receptor (PPAR) agonist, reportedly attenuated tau pathology in a transgenic mouse model of primary tauopathy. Since tau pathology is a neuropathological hallmark of Alzheimer’s disease (AD), bez
Externí odkaz:
https://doaj.org/article/3a9c85c26b2e4b32a089ac028b5698d0
Publikováno v:
Journal of the Formosan Medical Association, Vol 116, Iss 6, Pp 469-475 (2017)
The aims of the current study were to determine whether patients with conduct disorder (CD) showed an abnormal availability of serotonin reuptake transporter (SERT), and if their hyperkinetic symptoms, impulsivity, and quality of life were correlated
Externí odkaz:
https://doaj.org/article/ea83c82389b24f1ba2ff8d2b707f07cb
Autor:
Kang-Po Li, Ming-Kuan Hu, Cheng-Yi Cheng, Li-Fan Hsu, Ta-Kai Chou, Chyng-Yann Shiue, Daniel H Shen
Publikováno v:
Journal of Medical Sciences, Vol 37, Iss 1, Pp 7-11 (2017)
Aims: 11C-L-methionine, an amino acid tracer used to delineate certain tumor tissues, has proven to be a prevailing nonfluorodeoxyglucose positron emission tomography (PET) radiopharmaceutical. We intended to prepare 11C-L-methionine by following mod
Externí odkaz:
https://doaj.org/article/36f51549f8794eeca8acb1049956a544
Autor:
Ya-Yao Huang, Ming-Jang Chiu, Ruoh-Fang Yen, Chia-Ling Tsai, Hao-Yu Hsieh, Ching-Hung Chiu, Chi-Han Wu, Ling-Wei Hsin, Kai-Yuan Tzen, Cheng-Yi Cheng, Kuo-Hsing Ma, Chyng-Yann Shiue
Publikováno v:
PLoS ONE, Vol 14, Iss 7, p e0217384 (2019)
[18F]T807 is a potent tau protein imaging agent. In order to fulfill the demand from preclinical and clinical studies, we developed an automated one-pot two-step synthesis of this potent tau imaging agent and studied its stability, and dosimetry in m
Externí odkaz:
https://doaj.org/article/fbb6fd12c58043fcb52ffadd1b0526bf
Autor:
Ling-Yun Fan, Kai-Yuan Tzen, Ya-Fang Chen, Ta-Fu Chen, Ya-Mei Lai, Ruoh-Fang Yen, Ya-Yao Huang, Chyng-Yann Shiue, Shieh-Yueh Yang, Ming-Jang Chiu
Publikováno v:
Frontiers in Aging Neuroscience, Vol 10 (2018)
Background: Neuritic plaques and neurofibrillary tangles are the pathological hallmarks of Alzheimer’s disease (AD), while the role of brain amyloid deposition in the clinical manifestation or brain atrophy remains unresolved. We aimed to explore t
Externí odkaz:
https://doaj.org/article/8d4ebcf11594421281d7371b12e42c63
Autor:
Yun-Ting Jhao, Chuang-Hsin Chiu, Chien-Fu F. Chen, Ta-Kai Chou, Yi-Wen Lin, Yu-Ten Ju, Shinn-Chih Wu, Ruoh-Fang Yan, Chyng-Yann Shiue, Sheau-Huei Chueh, Christer Halldin, Cheng-Yi Cheng, Kuo-Hsing Ma
Publikováno v:
Cells, Vol 8, Iss 11, p 1420 (2019)
Intra-striatal transplantation of fetal ventral mesencephalic (VM) tissue has a therapeutic effect on patients with Parkinson’s disease (PD). Sertoli cells (SCs) possess immune-modulatory properties that benefit transplantation. We hypothesized tha
Externí odkaz:
https://doaj.org/article/9e9881e36d944bd18b1b889ac0c1cbf5