Lymphocyte HVEM/BTLA co-expression after critical illness demonstrates severity indiscriminate upregulation, impacting critical illness-induced immunosuppression

Autor: Michelle E. Wakeley, Brandon E. Armstead, Chyna C. Gray, Elizabeth W. Tindal, Daithi S. Heffernan, Chun-Shiang Chung, Alfred Ayala

Publikováno v: Frontiers in Medicine, Vol 10 (2023)

IntroductionThe co-regulatory molecule, HVEM, can stimulate or inhibit immune function, but when co-expressed with BTLA, forms an inert complex preventing signaling. Altered HVEM or BTLA expression, separately have been associated with increased noso

Externí odkaz: https://doaj.org/article/83163f96fcf14bb6821f1ebda560f9ab

Negative Immune Checkpoint Protein, VISTA, Regulates the CD4+ Treg Population During Sepsis Progression to Promote Acute Sepsis Recovery and Survival

Autor: Chyna C. Gray, Bethany Biron-Girard, Michelle E. Wakeley, Chun-Shiang Chung, Yaping Chen, Yael Quiles-Ramirez, Jessica D. Tolbert, Alfred Ayala

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Sepsis is a systemic immune response to infection that is responsible for ~35% of in-hospital deaths and over 24 billion dollars in annual treatment costs. Strategic targeting of non-redundant negative immune checkpoint protein pathways can cater the

Externí odkaz: https://doaj.org/article/909a49a7f38f4cddbef7a16bcfb3a0b4

Check Point Inhibitors and Their Role in Immunosuppression in Sepsis

Autor: Chyna C. Gray, Daithi S. Heffernan, Sean F. Monaghan, Michelle E. Wakeley, Alfred Ayala

Publikováno v: Crit Care Clin

Checkpoint regulators are a group of membrane-bound receptors or ligands expressed on immune cells to regulate the immune cell response to antigen presentation and other immune stimuli, such as cytokines, chemokines, and complement. In the context of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15563ff1bf92f3ea3be32145e0ad7196
https://pubmed.ncbi.nlm.nih.gov/31733683

Program Cell Death Receptor-1-Mediated Invariant Natural Killer T-Cell Control of Peritoneal Macrophage Modulates Survival in Neonatal Sepsis.

Autor: Fallon EA; Division of Surgical Research, Department of Surgery, Brown University and Rhode Island Hospital, Providence, RI, United States., Chun TT; Division of Surgical Research, Department of Surgery, Brown University and Rhode Island Hospital, Providence, RI, United States., Young WA; Division of Surgical Research, Department of Surgery, Brown University and Rhode Island Hospital, Providence, RI, United States., Gray C; Division of Surgical Research, Department of Surgery, Brown University and Rhode Island Hospital, Providence, RI, United States., Ayala A; Division of Surgical Research, Department of Surgery, Brown University and Rhode Island Hospital, Providence, RI, United States., Heffernan DS; Division of Surgical Research, Department of Surgery, Brown University and Rhode Island Hospital, Providence, RI, United States.

Publikováno v: Frontiers in immunology [Front Immunol] 2017 Nov 20; Vol. 8, pp. 1469. Date of Electronic Publication: 2017 Nov 20 (Print Publication: 2017).