Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Chye Yun, Yu"'
Autor:
Kee Woei Ng, Chye Yun Yu, Faith See, Zhi Wei Sim, Sijie Tan, Nyo Min, Brianna Lee, Archana Gautam, Zun Siong Low, Justin Jang Hann Chu, Esther Wong
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-18 (2019)
Scientific Reports
Scientific Reports
Mitochondrial dysfunction underscores aging and diseases. Mitophagy (mitochondria + autophagy) is a quality control pathway that preserves mitochondrial health by targeting damaged mitochondria for autophagic degradation. Hence, molecules or compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6be7d48e874073bd5bf2c0f0e2fd396
http://link.springer.com/article/10.1038/s41598-018-37400-1
http://link.springer.com/article/10.1038/s41598-018-37400-1
Autor:
Jue Jin Wang, Dejie Yu, Jia Lin Soon, Chye Yun Yu, Zhenyu Hu, Ping Liao, Tan Fong Yong, Mui Cheng Liang, Gandi Ng, Tuck Wah Soong, Yeow Leng Chua
Publikováno v:
Journal of Biological Chemistry. 290:9262-9272
L-type Cav1.2 Ca(2+) channel undergoes extensive alternative splicing, generating functionally different channels. Alternatively spliced Cav1.2 Ca(2+) channels have been found to be expressed in a tissue-specific manner or under pathological conditio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ca0d96b34490b67486587a618485740
https://doi.org/10.1074/jbc.m114.594911
https://doi.org/10.1074/jbc.m114.594911
Autor:
Guang, Li, Juejin, Wang, Ping, Liao, Peter, Bartels, Hengyu, Zhang, Dejie, Yu, Mui Cheng, Liang, Kian Keong, Poh, Chye Yun, Yu, Fengli, Jiang, Tan Fong, Yong, Yuk Peng, Wong, Zhenyu, Hu, Hua, Huang, Guangqin, Zhang, Mary Joyce, Galupo, Jin-Song, Bian, Sathivel, Ponniah, Scott Lee, Trasti, Kelvin, See, Roger, Foo, Uta C, Hoppe, Stefan, Herzig, Tuck Wah, Soong
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 114(21)
To directly address in vivo significance of the altered CaV1.2 channel property arising from alternative splicing, we generated CaV1.2 exon 33-specific knockout (exon 33−/−) mice. Here, we showed that the exclusion of alternative exon 33 altered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0fde7935dc7896b1aa58e14dc2f27262
https://pubmed.ncbi.nlm.nih.gov/28490495
https://pubmed.ncbi.nlm.nih.gov/28490495
Autor:
Yuk Peng Wong, Jin-Song Bian, Mary Joyce Galupo, Sathivel Ponniah, Juejin Wang, Chye Yun Yu, Peter Bartels, Uta C. Hoppe, Guang Li, Dejie Yu, Stefan Herzig, Fengli Jiang, Mui Cheng Liang, Ping Liao, Hua Huang, Guangqin Zhang, Kelvin See, Kian Keong Poh, Hengyu Zhang, Scott L. Trasti, Roger Foo, Tuck Wah Soong, Zhenyu Hu, Tan Fong Yong
Publikováno v:
Proceedings of the National Academy of Sciences. 114
Alternative splicing changes the CaV1.2 calcium channel electrophysiological property, but the in vivo significance of such altered channel function is lacking. Structure-function studies of heterologously expressed CaV1.2 channels could not recapitu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45e6f1a9511930b1886a4d6771419e5a
https://doi.org/10.1073/pnas.1617205114
https://doi.org/10.1073/pnas.1617205114
Autor:
Chee Kong Fhu, Bernd Nilius, Ping Liao, Gandi Ng, Dejie Yu, Chye Yun Yu, Kok Poh Loh, Rudi Vennekens, Tuck Wah Soong
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 466:563-576
Transient receptor potential melastatin 4 (TRPM4) is a voltage-dependent, nonselective cation channel. Under pathological conditions, sustained activation of TRPM4 leads to oncotic cell death. Here, we report the upregulation of TRPM4 in vascular end
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b90405b56977c629f4002bcf9c03a34f
https://doi.org/10.1007/s00424-013-1347-4
https://doi.org/10.1007/s00424-013-1347-4
Publikováno v:
Journal of Biological Chemistry. 284:19623-19636
The Sprouty (Spry) proteins act as inhibitors of the Ras/ERK pathway downstream of receptor tyrosine kinases. In this study, we report a novel interaction between protein kinase C delta (PKCdelta) and Spry2. Endogenous PKCdelta and Spry2 interact in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1957159ef05c8f879daf28c7fff97a1
https://doi.org/10.1074/jbc.m109.021600
https://doi.org/10.1074/jbc.m109.021600
Autor:
Pei Qi Lim, Fui-Mee Ng, Chye Yun Yu, Leng-Hiong Lim, Esther Wong, Chian-Ming Low, Stephen F. Traynelis
Publikováno v:
Protein Science. 14:2275-2283
N-methyl-D-aspartate (NMDA) receptors are involved in mediating excitatory synaptic transmissions in the brain and have been implicated in numerous neurologic disorders. The proximal amino-terminal domains (ATDs) of NMDA receptors constitute many mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efa718771ca03d424d1b049267766652
https://doi.org/10.1110/ps.051509905
https://doi.org/10.1110/ps.051509905
Autor:
Sophia S.H. Yang, Yuk Peng Wong, Shengnan Li, Chye Yun Yu, Ping Liao, Dejie Yu, Juejin Wang, Tuck Wah Soong, Sharon S.C. Thio
Publikováno v:
Circulation research. 109(11)
Rationale: Ca V 1.2 channels are essential for excitation–contraction coupling in the cardiovascular system, and alternative splicing optimizes its role. Galectin-1 (Gal-1) has been reported to regulate vascular smooth muscle cell (VSMC) function a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50f1eae9c51afc558a81b0463d27bf17
https://pubmed.ncbi.nlm.nih.gov/21998324
https://pubmed.ncbi.nlm.nih.gov/21998324
Autor:
Chye Yun Yu, Permeen Yusoff, Hwei Fen Leong, Kensaku Mizuno, Dieu-Hung Lao, Sumana Chandramouli, Graeme R. Guy
Publikováno v:
The Journal of biological chemistry. 283(3)
The Sprouty (Spry) proteins function as inhibitors of the Ras-ERK pathway downstream of various receptor tyrosine kinases. In this study, we have identified Tesk1 (testicular protein kinase 1) as a novel regulator of Spry2 function. Endogenous Tesk1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09d0431bf0c76faa45199d3dbdd5c4f0
https://pubmed.ncbi.nlm.nih.gov/17974561
https://pubmed.ncbi.nlm.nih.gov/17974561
Autor:
Dieu-Hung Lao, Tzuen Yih Saw, Chye Yun Yu, Chee Wai Fong, Permeen Yusoff, Sumana Chandramouli, Rebecca A. Jackson, Graeme R. Guy, Robin J. Philp
Publikováno v:
The Journal of biological chemistry. 282(12)
In the context of fibroblast growth factor (FGF) signaling, Sprouty2 (Spry2) is the most profound inhibitor of the Ras/ERK pathway as compared with other Spry isoforms. An exclusive, necessary, but cryptic PXXPXR motif in the C terminus of Spry2 is r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1262186062259ee24a065960e1f00594
https://pubmed.ncbi.nlm.nih.gov/17255109
https://pubmed.ncbi.nlm.nih.gov/17255109