First-in-Human Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of a Rapidly Developed SARS-CoV-2 Therapeutic Antibody, AOD01, in Healthy Adults.

Autor: Prativadibhayankaram, Venkateshan S.¹ (AUTHOR), Lee, Lawrence Soon-U² (AUTHOR), Lye, David^2,3,4 (AUTHOR), Xiaoying, Xu² (AUTHOR), Nellore, Ranjani¹ (AUTHOR), Pendharkar, Vishal¹ (AUTHOR), Hentze, Hannes¹ (AUTHOR), Guan, Siyu⁵ (AUTHOR), Ayers, Benjamin J.⁵ (AUTHOR), Seah, Shirley G. K.⁶ (AUTHOR), Chye, De Hoe⁶ (AUTHOR), Talib, Najwa S. N.⁷ (AUTHOR), Kaliaperumal, Nivashini⁷ (AUTHOR), Ong, Wei Yee⁷ (AUTHOR), Wong, Zi Xin⁷ (AUTHOR), Au, Veonice B.⁷ (AUTHOR), Alok, Anshula⁷ (AUTHOR), Connolly, John E.^7,8 (AUTHOR), Boyd-Kirkup, Jerome D.⁵ (AUTHOR), Ingram, Piers J.⁵ (AUTHOR)

Publikováno v: Infectious Diseases & Therapy. Oct2022, Vol. 11 Issue 5, p1999-2015. 17p.

Defining the determinants of protection against SARS-CoV-2 infection and viral control in a dose-down Ad26.CoV2.S vaccine study in nonhuman primates.

Autor: Zhu, Daniel Y.¹ (AUTHOR), Gorman, Matthew J.² (AUTHOR), Yuan, Dansu² (AUTHOR), Yu, Jingyou³ (AUTHOR), Mercado, Noe B.³ (AUTHOR), McMahan, Katherine³ (AUTHOR), Borducchi, Erica N.³ (AUTHOR), Lifton, Michelle³ (AUTHOR), Liu, Jinyan³ (AUTHOR), Nampanya, Felix³ (AUTHOR), Patel, Shivani³ (AUTHOR), Peter, Lauren³ (AUTHOR), Tostanoski, Lisa H.³ (AUTHOR), Pessaint, Laurent⁴ (AUTHOR), Van Ry, Alex⁴ (AUTHOR), Finneyfrock, Brad⁴ (AUTHOR), Velasco, Jason⁴ (AUTHOR), Teow, Elyse⁴ (AUTHOR), Brown, Renita⁴ (AUTHOR), Cook, Anthony⁴ (AUTHOR)

Publikováno v: PLoS Biology. 5/5/2022, Vol. 20 Issue 5, p1-25. 25p. 1 Diagram, 6 Graphs.

Convalescent human IgG, but not IgM, from COVID-19 survivors confers dosedependent protection against SARS-CoV-2 replication and disease in hamsters.

Autor: King, Hannah A. D., Dussupt, Vincent, Mendez-Rivera, Letzibeth, Slike, Bonnie M., Tran, Ursula, Jackson, Nathan D., Barkei, Erica, Zemil, Michelle, Tourtellott-Fogt, Emily, Kuklis, Caitlin H., Soman, Sandrine, Ahmed, Aslaa, Porto, Maciel, Kitajewski, Christopher, Spence, Brittany, Benetiene, Dalia, Wieczorek, Lindsay, Kar, Swagata, Gromowski, Gregory, Polonis, Victoria R.

Publikováno v: Frontiers in Immunology; 3/21/2023, Vol. 14, p1-14, 14p

SARS-CoV-2 infection triggers more potent antibody-dependent cellular cytotoxicity (ADCC) responses than mRNA-, vector-, and inactivated virus-based COVID-19 vaccines.

Autor: Zedan HT; Infectious Diseases Department, Biomedical Research Center, Research Complex, Qatar University, Doha, Qatar.; Department of Biomedical Science, College of Health Sciences, Member of QU Health, Qatar University, Doha, Qatar., Smatti MK; Infectious Diseases Department, Biomedical Research Center, Research Complex, Qatar University, Doha, Qatar., Al-Sadeq DW; College of Medicine, Member of QU Health, Qatar University, Doha, Qatar., Al Khatib HA; Infectious Diseases Department, Biomedical Research Center, Research Complex, Qatar University, Doha, Qatar., Nicolai E; Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy., Pieri M; Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy., Bernardini S; Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy., Hssain AA; Medical Intensive Care Unit, Hamad Medical Corporation, Doha, Qatar., Taleb S; Department of Research, Weill Cornell Medicine-Qatar, Doha, Qatar., Qotba H; Department of Clinical Research, Primary Health Care Centers, Doha, Qatar.; Department of Pathology, Sidra Medicine, Doha, Qatar., Issa K; Proteomics, Inflammatory Response, and Mass Spectrometry (PRISM) Laboratory, INSERM U-1192, University of Lille, Lille, France., Abu Raddad LJ; Department of Population Health Sciences, Infectious Disease Epidemiology Group, Weill Cornell Medicine-Qatar, Doha, Qatar., Althani AA; Infectious Diseases Department, Biomedical Research Center, Research Complex, Qatar University, Doha, Qatar.; Department of Biomedical Science, College of Health Sciences, Member of QU Health, Qatar University, Doha, Qatar., Nasrallah GK; Infectious Diseases Department, Biomedical Research Center, Research Complex, Qatar University, Doha, Qatar.; Department of Biomedical Science, College of Health Sciences, Member of QU Health, Qatar University, Doha, Qatar., Yassine HM; Infectious Diseases Department, Biomedical Research Center, Research Complex, Qatar University, Doha, Qatar.

Publikováno v: Journal of medical virology [J Med Virol] 2024 Mar; Vol. 96 (3), pp. e29527.

Molecular variants of SARS-CoV-2: antigenic properties and current vaccine efficacy.

Autor: Rayati Damavandi, Amirmasoud, Dowran, Razieh, Al Sharif, Sarah, Kashanchi, Fatah, Jafari, Reza

Publikováno v: Medical Microbiology & Immunology; Jun2022, Vol. 211 Issue 2/3, p79-103, 25p