Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Chuyu Chen"'
Autor:
Harry S. Xenias, Chuyu Chen, Shuo Kang, Suraj Cherian, Xiaolei Situ, Bharanidharan Shanmugasundaram, Guoxiang Liu, Giuseppe Scesa, C. Savio Chan, Loukia Parisiadou
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
Abstract LRRK2 mutations are closely associated with Parkinson’s disease (PD). Convergent evidence suggests that LRRK2 regulates striatal function. Here, by using knock-in mouse lines expressing the two most common LRRK2 pathogenic mutations—G201
Externí odkaz:
https://doaj.org/article/0a23718f268548469f30d522e7f56b2e
Autor:
Kellen Mulford, Chuyu Chen, Kathryn Dusenbery, Jianling Yuan, Matthew A. Hunt, Clark C. Chen, Paul Sperduto, Yoichi Watanabe, Christopher Wilke
Publikováno v:
Clinical and Translational Radiation Oncology, Vol 29, Iss , Pp 27-32 (2021)
Purpose: Adjuvant radiosurgery to the cavities of surgically resected brain metastases provides excellent local tumor control while reducing the risk of deleterious cognitive decline associated with whole brain radiotherapy. A subset of these patient
Externí odkaz:
https://doaj.org/article/2977a3e760074092a0303755672151a1
Autor:
Chuyu Chen, Giulia Soto, Vasin Dumrongprechachan, Nicholas Bannon, Shuo Kang, Yevgenia Kozorovitskiy, Loukia Parisiadou
Publikováno v:
eLife, Vol 9 (2020)
LRRK2 is a kinase expressed in striatal spiny projection neurons (SPNs), cells which lose dopaminergic input in Parkinson’s disease (PD). R1441C and G2019S are the most common pathogenic mutations of LRRK2. How these mutations alter the structure a
Externí odkaz:
https://doaj.org/article/5fcdaad6fe0b4d8c9c73a5ffb1b0ec7c
Autor:
Giulia Tombesi, Chuyu Chen, Giulia Favetta, Nicoletta Plotegher, Martina Sevegnani, Antonella Marte, Ilaria Battisti, Laura Civiero, Franco Onofri, Giovanni Piccoli, Giorgio Arrigoni, Claudia Manzoni, Loukia Parisiadou, Elisa Greggio
Dendritic spines, small protrusions of the dendrites, constitute the postsynaptic compartment of excitatory synapses. Filamentous actin is the major cytoskeletal constituent of dendritic spines, whose dynamic nature allows them to plastically remodel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c8f110847542ad4bfe0aeaaf7ae510f
https://doi.org/10.1101/2022.10.31.514622
https://doi.org/10.1101/2022.10.31.514622
Autor:
Chuyu Chen
Stereotaxic injection of viral vectors for gene knockdown experiments : The AAV vectors for knocking down the gene of interest were custom-made with Vector Biolabs using AAV-GFP-U6 vector for AAV1 packaging (Cat no, 7040, Vector Biolabs). They were t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93308e0f597b6f6cb830720c1f56e6aa
https://doi.org/10.17504/protocols.io.q26g7y819gwz/v1
https://doi.org/10.17504/protocols.io.q26g7y819gwz/v1
Autor:
Chuyu Chen
These two protocols describe behavioral tests associated with Parkinson’s disease phenotypes in mice. The striatal motor learning protocol (rotarod test) is a two-phase paradigm assessing striatal motor learning under reversible dopamine antagonism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::524c6574377f269741f188096565ffb8
https://doi.org/10.17504/protocols.io.261ge345jl47/v1
https://doi.org/10.17504/protocols.io.261ge345jl47/v1
Autor:
Wei-Qi Wei, Erin Smithberger, Jennifer A. Pacheco, Gail P. Jarvik, Madeleine Horvath, James G. Linneman, Tanima De, Loukia Parisiadou, Cristina Alarcon, Adam S. Gordon, Juan Avitia, Scott J. Hebbring, Patrick M. A. Sleiman, Chuyu Chen, Hakon Hakonarson, Sarbani Adhikari, Minoli A. Perera, Sara Kwan, Honghong Zhang, Mary Young, John H. Kwon, John B. Harley, Bianca Lec, Frank D. Mentch
Publikováno v:
Pharmacogenet Genomics
OBJECTIVE Primary non-response (PNR) to anti-tumor necrosis factor-α (TNFα) biologics is a serious concern in patients with inflammatory bowel disease (IBD). We aimed to identify the genetic variants associated with PNR. DESIGN Patients were recrui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea5483721f498d4e4268913df2c5224c
https://doi.org/10.1097/fpc.0000000000000445
https://doi.org/10.1097/fpc.0000000000000445
Autor:
Christopher Wilke, Chuyu Chen, Yoichi Watanabe, Matthew A. Hunt, Clark C. Chen, Jianling Yuan, Paul W. Sperduto, Kathryn E. Dusenbery, Kellen Mulford
Publikováno v:
Clinical and Translational Radiation Oncology
Clinical and Translational Radiation Oncology, Vol 29, Iss, Pp 27-32 (2021)
Clinical and Translational Radiation Oncology, Vol 29, Iss, Pp 27-32 (2021)
Highlights • SRS has emerged as an alternative to WBRT for surgically resected brain metastases. • Pre-therapy radiomic features are predictive of local control after cavity SRS. • Radiomic features were superior to clinical features for predic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a5c7932d8e20b6e7043063cdb1225f7
https://doi.org/10.1016/j.ctro.2021.05.001
https://doi.org/10.1016/j.ctro.2021.05.001
Autor:
Chuyu Chen
LRRK2 is a widely expressed, multifunctional protein.LRRK2 mutations are the major cause to inherited and sporadic PD. Staining of LRRK2 in mouse brain can be challenging. This protocol provides an optimised way to achieve LRRK2 staining in mouse bra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae913d9ccc9be35749b7f41c8b20bfa1
https://doi.org/10.17504/protocols.io.e6nvwj64dlmk/v1
https://doi.org/10.17504/protocols.io.e6nvwj64dlmk/v1
Autor:
Chuyu Chen
Coated cover-slips provide a nourishing adherent surface for cell culture. This protocol provides step by step instruction on how to coat coverslips for cell culture.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42d05fb9b859e53c83f297c5b79e0b04
https://doi.org/10.17504/protocols.io.5qpvornd9v4o/v1
https://doi.org/10.17504/protocols.io.5qpvornd9v4o/v1