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Germline-targeting SOSIP trimer immunization elicits precursor CD4 binding-site targeting broadly neutralizing antibodies in infant macaques.

Autor: Nelson AN; Department of Pediatrics, Weill Cornell Medicine; New York, NY, USA., Shen X; Human Vaccine Institute, Duke University Medical Center; Durham, NC, USA., Vekatayogi S; Human Vaccine Institute, Duke University Medical Center; Durham, NC, USA., Zhang S; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Ozorowski G; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Dennis M; Department of Pediatrics, Weill Cornell Medicine; New York, NY, USA., Sewall LM; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Milligan E; Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill; Chapel Hill, NC, USA., Davis D; Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill; Chapel Hill, NC, USA., Cross KA; Gillings School of Public Health and Center for AIDS Research, University of North Carolina at Chapel Hill; Chapel Hill, NC, USA., Chen Y; Human Vaccine Institute, Duke University Medical Center; Durham, NC, USA., van Schooten J; Department of Medical Microbiology, Academic Medical Center; Amsterdam, Netherlands., Eudailey J; Department of Pediatrics, Weill Cornell Medicine; New York, NY, USA., Isaac J; Department of Pediatrics, Weill Cornell Medicine; New York, NY, USA., Memon S; Department of Pediatrics, Weill Cornell Medicine; New York, NY, USA., Weinbaum C; Department of Pediatrics, Weill Cornell Medicine; New York, NY, USA., Stanfield-Oakley S; Human Vaccine Institute, Duke University Medical Center; Durham, NC, USA., Byrd A; Human Vaccine Institute, Duke University Medical Center; Durham, NC, USA., Chutkan S; Human Vaccine Institute, Duke University Medical Center; Durham, NC, USA., Berendam S; Human Vaccine Institute, Duke University Medical Center; Durham, NC, USA., Cronin K; Human Vaccine Institute, Duke University Medical Center; Durham, NC, USA., Yasmeen A; Department of Microbiology and Immunology, Weill Cornell Medicine; New York, NY, USA., Alam SM; Human Vaccine Institute, Duke University Medical Center; Durham, NC, USA., LaBranche CC; Human Vaccine Institute, Duke University Medical Center; Durham, NC, USA., Rogers K; New Iberia Research Center, University of Louisiana at Lafayette, New Iberia, LA, USA., Shirreff L; New Iberia Research Center, University of Louisiana at Lafayette, New Iberia, LA, USA., Cupo A; Department of Microbiology and Immunology, Weill Cornell Medicine; New York, NY, USA., Derking R; Department of Medical Microbiology, Academic Medical Center; Amsterdam, Netherlands.; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, the Netherlands., Villinger F; New Iberia Research Center, University of Louisiana at Lafayette, New Iberia, LA, USA., Klasse PJ; Department of Microbiology and Immunology, Weill Cornell Medicine; New York, NY, USA., Ferrari G; Human Vaccine Institute, Duke University Medical Center; Durham, NC, USA., Williams WB; Human Vaccine Institute, Duke University Medical Center; Durham, NC, USA., Hudgens MG; Gillings School of Public Health and Center for AIDS Research, University of North Carolina at Chapel Hill; Chapel Hill, NC, USA., Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Montefiori DC; Human Vaccine Institute, Duke University Medical Center; Durham, NC, USA., Van Rompay KKA; California National Primate Research Center, University of California; Davis, CA, USA., Wiehe K; Human Vaccine Institute, Duke University Medical Center; Durham, NC, USA., Moore JP; Department of Microbiology and Immunology, Weill Cornell Medicine; New York, NY, USA., Sanders RW; Department of Medical Microbiology, Academic Medical Center; Amsterdam, Netherlands.; Department of Microbiology and Immunology, Weill Cornell Medicine; New York, NY, USA.; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, the Netherlands., De Paris K; Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill; Chapel Hill, NC, USA., Permar SR; Department of Pediatrics, Weill Cornell Medicine; New York, NY, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Nov 11. Date of Electronic Publication: 2023 Nov 11.