Short-chain fatty and carboxylic acid changes associated with fecal microbiota transplant communally influence microglial inflammation

Autor: Churchward, MA, Michaud, ER, Mullish, BH, Miguens Blanco, J, Garcia Perez, I, Marchesi, JR, Xu, H, Kao, D, Todd, KG

The intestinal microbiota has been proposed to influence human mental health and cognition through the gut-brain axis. Individuals experiencing recurrent Clostridioides difficile infection (rCDI) frequently report depressive symptoms, which are impro

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http://hdl.handle.net/10044/1/104669

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Toward discovering a novel family of peptides targeting neuroinflammatory states of brain microglia and astrocytes.

Autor: Koss KM; Comprehensive Transplant Center and Department of Surgery, Feinberg School of Medicine, Northwestern University, Illinois, Chicago, USA.; Neurochemical Research Unit, Department of Psychiatry, University of Alberta, Alberta, Edmonton, Canada.; Department of Surgery, University of Arizona College of Medicine, Arizona, Tucson, USA., Son T; Comprehensive Transplant Center and Department of Surgery, Feinberg School of Medicine, Northwestern University, Illinois, Chicago, USA., Li C; Department of Chemistry, University of Alberta, 11227 Saskatchewan Dr NW, Edmonton, AB T6G 2G2, Canada., Hao Y; Department of Chemistry, University of Alberta, 11227 Saskatchewan Dr NW, Edmonton, AB T6G 2G2, Canada., Cao J; Department of Chemistry, University of Alberta, 11227 Saskatchewan Dr NW, Edmonton, AB T6G 2G2, Canada.; 48Hour Discovery Inc, 11421 Saskatchewan Dr NW, Edmonton, AB T6G 2M9, Canada., Churchward MA; Neurochemical Research Unit, Department of Psychiatry, University of Alberta, Alberta, Edmonton, Canada.; Neuroscience and Mental Health Institute, University of Alberta, Alberta, Edmonton, Canada.; Department of Biology and Environmental Sciences, Concordia University of Edmonton, Alberta, Edmonton, Canada., Zhang ZJ; Comprehensive Transplant Center and Department of Surgery, Feinberg School of Medicine, Northwestern University, Illinois, Chicago, USA., Wertheim JA; Comprehensive Transplant Center and Department of Surgery, Feinberg School of Medicine, Northwestern University, Illinois, Chicago, USA.; Department of Surgery, University of Arizona College of Medicine, Arizona, Tucson, USA., Derda R; Department of Chemistry, University of Alberta, 11227 Saskatchewan Dr NW, Edmonton, AB T6G 2G2, Canada.; 48Hour Discovery Inc, 11421 Saskatchewan Dr NW, Edmonton, AB T6G 2M9, Canada., Todd KG; Neurochemical Research Unit, Department of Psychiatry, University of Alberta, Alberta, Edmonton, Canada.; Neuroscience and Mental Health Institute, University of Alberta, Alberta, Edmonton, Canada.; Department of Biomedical Engineering, University of Alberta, Alberta, Edmonton, Canada.

Publikováno v: Journal of neurochemistry [J Neurochem] 2024 Oct; Vol. 168 (10), pp. 3386-3414. Date of Electronic Publication: 2023 Jun 14.

Pleiotrophin Signals Through ALK Receptor to Enhance the Growth of Neurons in the Presence of Inhibitory Chondroitin Sulfate Proteoglycans.

Autor: Gupta SJ; Neurochemical Research Unit, Department of Psychiatry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.; Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada., Churchward MA; Neurochemical Research Unit, Department of Psychiatry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.; Department of Biology and Environmental Sciences, Concordia University of Edmonton, Edmonton, AB, Canada., Todd KG; Neurochemical Research Unit, Department of Psychiatry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.; Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada., Winship IR; Neurochemical Research Unit, Department of Psychiatry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.; Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada.

Publikováno v: Neuroscience insights [Neurosci Insights] 2023 Jul 15; Vol. 18, pp. 26331055231186993. Date of Electronic Publication: 2023 Jul 15 (Print Publication: 2023).

The effects of electrical stimulation on glial cell behaviour.

Autor: Tsui CT; Neurochemical Research Unit, Department of Psychiatry, University of Alberta, Edmonton, AB, T6G 2G3, Canada.; Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, T6G 2E1, Canada.; Department of Biomedical Engineering, University of Alberta, Edmonton, AB, T6G 2V2, Canada., Lal P; Neurochemical Research Unit, Department of Psychiatry, University of Alberta, Edmonton, AB, T6G 2G3, Canada.; Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, T6G 2E1, Canada., Fox KVR; Neurochemical Research Unit, Department of Psychiatry, University of Alberta, Edmonton, AB, T6G 2G3, Canada.; Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, T6G 2E1, Canada., Churchward MA; Neurochemical Research Unit, Department of Psychiatry, University of Alberta, Edmonton, AB, T6G 2G3, Canada.; Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, T6G 2E1, Canada.; Department of Biological and Environmental Sciences, Concordia University of Edmonton, Edmonton, AB, T5B 4E4, Canada., Todd KG; Neurochemical Research Unit, Department of Psychiatry, University of Alberta, Edmonton, AB, T6G 2G3, Canada. kgtodd@ualberta.ca.; Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, T6G 2E1, Canada. kgtodd@ualberta.ca.; Department of Biomedical Engineering, University of Alberta, Edmonton, AB, T6G 2V2, Canada. kgtodd@ualberta.ca.

Publikováno v: BMC biomedical engineering [BMC Biomed Eng] 2022 Sep 03; Vol. 4 (1), pp. 7. Date of Electronic Publication: 2022 Sep 03.