Zobrazeno 1 - 10
of 140
pro vyhledávání: '"Chuo Chen"'
Autor:
Yong Lu, Lin You, Liping Li, Jessica A. Kilgore, Shun Liu, Xiaoyu Wang, Yuanwei Dai, Qi Wei, Heping Shi, Lei Han, Lijun Sun, Zhijian J. Chen, Xuewu Zhang, Noelle S. Williams, Chuo Chen
Publikováno v:
ACS Central Science, Vol 9, Iss 12, Pp 2298-2305 (2023)
Externí odkaz:
https://doaj.org/article/2953af03e6d94562ad4941b50201775d
Publikováno v:
ARKIVOC: Online Journal of Organic Chemistry. 2023, Vol. 2023, p1-9. 9p.
Autor:
Li-shu Zhang, Xunlei Kang, Jianming Lu, Yuannyu Zhang, Xiaofeng Wu, Guojin Wu, Junke Zheng, Rubina Tuladhar, Heping Shi, Qiaoling Wang, Lorraine Morlock, Huiyu Yao, Lily Jun-shen Huang, Pascal Maire, James Kim, Noelle Williams, Jian Xu, Chuo Chen, Cheng Cheng Zhang, Lawrence Lum
Publikováno v:
EBioMedicine, Vol 39, Iss , Pp 145-158 (2019)
Background: Chromosomal translocation-induced expression of the chromatin modifying oncofusion protein MLL-AF9 promotes acute myelocytic leukemia (AML). Whereas WNT/β-catenin signaling has previously been shown to support MLL-AF9-driven leukemogenes
Externí odkaz:
https://doaj.org/article/73d06b7f64ea44e7a85caf179ec3fdad
Autor:
Chuo Chen
Publikováno v:
Organic Chemistry Frontiers. 10:1086-1098
This article describes how the synergy between chemistry and biology facilitated the development of cyclic dinucleotides as a potential new treatment for cancer.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eafde0f725e37bc204be4d85a676b21e
https://doi.org/10.1039/d2qo02033e
https://doi.org/10.1039/d2qo02033e
Publikováno v:
Chemical Communications. 58:12439-12442
Technologies for cysteine disulfide detection and conjugation are pivotal to understanding protein functions and developing disulfide-derived therapeutic agents. Currently, disulfide modification requires reductive cleavage prior to functionalization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57f8f150ebf4797d9d29bc738c112c6e
https://doi.org/10.1039/d2cc04967h
https://doi.org/10.1039/d2cc04967h
Autor:
You-tong Wu, Yan Fang, Qi Wei, Heping Shi, Huiling Tan, Yafang Deng, Zhiqun Zeng, Jian Qiu, Chuo Chen, Lijun Sun, Zhijian J. Chen
Publikováno v:
Proceedings of the National Academy of Sciences. 119
The cGAS-STING pathway is essential for immune defense against microbial pathogens and malignant cells; as such, STING is an attractive target for cancer immunotherapy. However, systemic administration of STING agonists poses safety issues while intr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b05cb45cfb9110cea68bb88a1bb4665
https://doi.org/10.1073/pnas.2214278119
https://doi.org/10.1073/pnas.2214278119
Autor:
She Chen, Yuyong Ma, Andrea N. Johnston, Shuzhen Liu, Hua Liu, Zhigao Wang, Chuo Chen, Sarah Hanna-Addams
Publikováno v:
Proc Natl Acad Sci U S A
Necroptosis is a regulated necrotic cell death pathway involved in development and disease. Its signaling cascade results in the formation of disulfide bond-dependent amyloid-like polymers of mixed lineage kinase domain-like protein (MLKL), which med
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9ceb89653b4b758660f5a2b0984e427
https://doi.org/10.1073/pnas.1916503117
https://doi.org/10.1073/pnas.1916503117
Publikováno v:
The Journal of Biological Chemistry
Ceramide is a lipid molecule that regulates diverse physiological and pathological reactions in part through inverting the topology of certain transmembrane proteins. This topological inversion is achieved through regulated alternative translocation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9df7e084b148bda858167de3f33b0719
http://europepmc.org/articles/PMC8665359
http://europepmc.org/articles/PMC8665359
Autor:
Jungsoo Han, Peng Li, Lei Han, Qing Ding, Chuo Chen, Yonghao Yu, Shuai Wang, Qing Jun Zhang, Zhi Ping Liu
Publikováno v:
Nature chemical biology
PARP1 inhibitors (PARPi) are known to kill tumor cells via two mechanisms (PARP1 catalytic inhibition and PARP1 trapping). The relative contribution of these two pathways in mediating the cytotoxicity of PARPi, however, is not well understood. Here w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::623d1f246afcd22e156b0f657b241734
https://doi.org/10.1038/s41589-019-0379-2
https://doi.org/10.1038/s41589-019-0379-2
Autor:
Lawrence G. Lum, Jeremiah Herbert, Yuyong Ma, Chuo Chen, Chengwei Zhang, James Kim, Nageswari Yarravarapu, Rubina Tuladhar
Publikováno v:
Journal of Biological Chemistry. 294:6273-6282
The maintenance of adult animal tissues depends upon highly conserved intercellular signaling molecules that include the secreted WNT proteins. Although it is generally accepted that lipidation of WNTs by the acyltransferase Porcupine (PORCN) and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fb2afb4abe25cb5b5cc5ab2a20f1288
https://doi.org/10.1074/jbc.ra118.007268
https://doi.org/10.1074/jbc.ra118.007268