Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Chunyuan, Zhao"'
Autor:
Danhui Qin, Hui Song, Caiwei Wang, Xiaojie Ma, Yu Fu, Chunyuan Zhao, Wei Zhao, Lei Zhang, Weifang Zhang
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract Stimulator of interferon genes (STING) is vital in the cytosolic DNA-sensing process and critical for initiating the innate immune response, which has important functions in host defense and contributes to the pathogenesis of inflammatory di
Externí odkaz:
https://doaj.org/article/028bb1b3034f4dc7a2f972ad099c9101
Autor:
Mutian Jia, Li Chai, Jie Wang, Mengge Wang, Danhui Qin, Hui Song, Yue Fu, Chunyuan Zhao, Chengjiang Gao, Jihui Jia, Wei Zhao
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Oxidative (or respiratory) burst confers host defense against pathogens by generating reactive species, including reactive nitrogen species (RNS). The microbial infection-induced excessive RNS damages many biological molecules via S-nitrosot
Externí odkaz:
https://doaj.org/article/c45f289119884bd0994eb2449a9c3ed9
Publikováno v:
FEBS Open Bio, Vol 13, Iss 12, Pp 2273-2289 (2023)
Eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP) is a subtype of chronic rhinosinusitis (CRS) that is associated with the nasal cavity and sinus polyps, elevated levels of eosinophils, and dysregulated immune responses to environmental
Externí odkaz:
https://doaj.org/article/7bcd5bde55b84453ac841edb792f5dd6
Autor:
Ying Qin, Xintong Meng, Mengge Wang, Wenbo Liang, Rong Xu, Jingchunyu Chen, Hui Song, Yue Fu, Jingxin Li, Chengjiang Gao, Mutian Jia, Chunyuan Zhao, Wei Zhao
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 20 (2023)
The NOD-, LRR-, and pyrin domain–containing protein 3 (NLRP3) inflammasome is a crucial component of the innate immune system that initiates inflammatory responses. Posttranslational modifications (PTMs) of NLRP3, including ubiquitination and phosp
Externí odkaz:
https://doaj.org/article/8310fce31c224c2a81b8fd577e2abc38
Autor:
Mutian Jia, Yuanyuan Wang, Jie Wang, Danhui Qin, Mengge Wang, Li Chai, Yue Fu, Chunyuan Zhao, Chengjiang Gao, Jihui Jia, Wei Zhao
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Stimulator of interferon gene (STING) plays critical roles in the host response to infection and in the production of interferon. Here the authors suggests myristic acid is involved in the homeostatic balancing of STING dependent autophagy and the in
Externí odkaz:
https://doaj.org/article/45a0ffd00a234efa961426f25252f1d4
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-8 (2022)
TOB1 is identified as an interferon regulatory factor 3 (IRF3) binding partner that operates as a negative feedback inhibitor of IFNβ in toll-like receptor and cytosolic nucleic acid receptor sensing pathways.
Externí odkaz:
https://doaj.org/article/79253c8a88d54990b539d19bf3cec736
Autor:
Lin Lv, Li Chai, Jie Wang, Mengge Wang, Danhui Qin, Hui Song, Yue Fu, Chunyuan Zhao, Jihui Jia, Wei Zhao, Mutian Jia
Publikováno v:
PLoS Pathogens, Vol 19, Iss 4, p e1011314 (2023)
Stimulator-of-interferon gene (STING) is a vital element of the innate immune system against DNA viruses. Optimal activation of STING is crucial for maintaining immune homeostasis and eliminating invading viruses, and the oligomerization of STING is
Externí odkaz:
https://doaj.org/article/9524f9c20da04213b2b34764d585b0fb
Publikováno v:
Sensors, Vol 23, Iss 17, p 7347 (2023)
Temperature sensors are widely used in industrial production and scientific research, and accurate temperature measurement is crucial for ensuring the quality and safety of production processes. To improve the accuracy and stability of temperature se
Externí odkaz:
https://doaj.org/article/fa0b317c1fec4e13a777241ceddf4073
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Post-translational modifications are important regulators of NLRP3 inflammasome activity. Here the authors show that the E3 ligase TRIM28 can SUMOylate NLRP3, thereby limiting its proteasomal degradation and increasing NLRP3 inflammasome activity.
Externí odkaz:
https://doaj.org/article/44f90e47855d43ca9739936ce57bb459
UAF1 deubiquitinase complexes facilitate NLRP3 inflammasome activation by promoting NLRP3 expression
Autor:
Hui Song, Chunyuan Zhao, Zhongxia Yu, Qizhao Li, Rongzhen Yan, Ying Qin, Mutian Jia, Wei Zhao
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
NLRP3 inflammasome activation is regulated by various signaling pathways to ensure inflammation does not go unchecked. Here the authors show how deubiquitination avoids this regulation to activate the NLRP3 inflammasome through the function of UAF1/U
Externí odkaz:
https://doaj.org/article/eef5b96d0c054b80adaa460a083c9c3c