Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Chunyu Cai"'
A molecular pathway for cancer cachexia-induced muscle atrophy revealed at single-nucleus resolution
Autor:
Yichi Zhang, Matthieu Dos Santos, Huocong Huang, Kenian Chen, Puneeth Iyengar, Rodney Infante, Patricio M. Polanco, Rolf A. Brekken, Chunyu Cai, Ambar Caijgas, Karla Cano Hernandez, Lin Xu, Rhonda Bassel-Duby, Ning Liu, Eric N. Olson
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114587- (2024)
Summary: Cancer cachexia is a prevalent and often fatal wasting condition that cannot be fully reversed with nutritional interventions. Muscle atrophy is a central component of the syndrome, but the mechanisms whereby cancer leads to skeletal muscle
Externí odkaz:
https://doaj.org/article/178060e694dc445f9c9795570d7dc38d
Autor:
Yu Xia, Zhengli Chen, Chao Huang, Liangqin Shi, Wenjing Ma, Xiwen Chen, Yucong Liu, Yao Wang, Chunyu Cai, Yixiang Huang, Wentao Liu, Riyi Shi, Qihui Luo
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 275, Iss , Pp 116241- (2024)
Iron overload occurs due to excessive iron intake compared to the body’s demand, leading to iron deposition and impairment of multiple organ functions. Our previous study demonstrated that chronic oral administration of ferric citrate (FC) caused c
Externí odkaz:
https://doaj.org/article/4fdc3bd58f8e4d9eaf58fa1759dc893c
Autor:
Yichi Zhang, Andres Ramirez-Martinez, Kenian Chen, John R. McAnally, Chunyu Cai, Mateusz Z. Durbacz, Francesco Chemello, Zhaoning Wang, Lin Xu, Rhonda Bassel-Duby, Ning Liu, Eric N. Olson
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 13 (2023)
Mutations in genes encoding nuclear envelope proteins lead to diseases known as nuclear envelopathies, characterized by skeletal muscle and heart abnormalities, such as Emery-Dreifuss muscular dystrophy (EDMD). The tissue-specific role of the nuclear
Externí odkaz:
https://doaj.org/article/089e6d82f4e743d5a199cbe608f89e95
Autor:
Elena V. Daoud, Kelsey Zhu, Bruce Mickey, Hussein Mohamed, Mandisa Wen, Michael Delorenzo, Ivy Tran, Jonathan Serrano, Kimmo J. Hatanpaa, Jack M. Raisanen, Matija Snuderl, Chunyu Cai
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-12 (2022)
Abstract Chordoid meningioma is a morphological variant of meningioma designated as WHO grade 2. However, the recurrence rates varied widely in different case series, and to date, a unifying molecular genetic signature has not been identified. Among
Externí odkaz:
https://doaj.org/article/13cb9aba473648c1bc9705a74565ba16
Autor:
Xun Wang, Yuemeng Jia, Jiawei Zhao, Nicholas P. Lesner, Cameron J. Menezes, Spencer D. Shelton, Siva Sai Krishna Venigalla, Jian Xu, Chunyu Cai, Prashant Mishra
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 23 (2022)
A fundamental issue in regenerative medicine is whether there exist endogenous regulatory mechanisms that limit the speed and efficiency of the repair process. We report the existence of a maturation checkpoint during muscle regeneration that pauses
Externí odkaz:
https://doaj.org/article/15b0cd65a0394ce191cd116aa3a38eda
Autor:
Bin He, Ya Zhan, Chunyu Cai, Dianyou Yu, Qinjiang Wei, Liping Quan, Da Huang, Yan Liu, Zhile Li, Li Liu, Xingshou Pan
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundAortic disease (aortic aneurysm (AA), dissection (AD)) is a serious threat to patient lives. Little is currently known about the molecular mechanisms and immune infiltration patterns underlying the development and progression of thoracic an
Externí odkaz:
https://doaj.org/article/eb433cccc2e840b7a13d74dbca95c39a
Autor:
Chunyu Cai, Qihui Luo, Lanlan Jia, Yu Xia, Xinting Lan, Xiaoli Wei, Shuai Shi, Yucong Liu, Yao Wang, Zongliang Xiong, Riyi Shi, Chao Huang, Zhengli Chen
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 17, p 13439 (2023)
In recent years, olfactory dysfunction has attracted increasingly more attention as a hallmark symptom of neurodegenerative diseases (ND). Deeply understanding the molecular basis underlying the development of the olfactory bulb (OB) will provide imp
Externí odkaz:
https://doaj.org/article/70bb9d8e768349a7b55ef0892a320ebf
Autor:
Chunyu Cai
Publikováno v:
Journal of Pathology and Translational Medicine, Vol 57, Iss 1, Pp 79-80 (2023)
This compilation of new changes in the diagnosis and treatment of muscle and nerve disease is extracted from the latest publications from the European Neuromuscular Centre International workshops, FDA.gov and clinicaltrials.gov.
Externí odkaz:
https://doaj.org/article/ab8042a061284b028b2147e175cc1ea2
Autor:
Heather N. Hayenga, Chunyu Cai, David Fetzer, Sarah White, Joshua Kuban, Zabi Wardak, Robert S. Benjamin, Edward Pan, James Strauss, Boning Gao, John Minna, Javier Martin-Broto, J Louis Hinshaw
Publikováno v:
Current Problems in Cancer: Case Reports, Vol 6, Iss , Pp 100149- (2022)
Hemangiopericytoma/Solitary Fibrous Tumor (HPC/SFT) is a rare fibroblastic sarcoma characterized by hyper-vasculature and STAT6 trans-nuclear localization. Cystic HPC/SFT is extremely rare. Due to the scarcity of cystic HPC/SFT cases, diagnostic and
Externí odkaz:
https://doaj.org/article/e17b61497d3c483c93bcbb74773b2bb7
Autor:
Andres Ramirez-Martinez, Yichi Zhang, Kenian Chen, Jiwoong Kim, Bercin K. Cenik, John R. McAnally, Chunyu Cai, John M. Shelton, Jian Huang, Ana Brennan, Bret M. Evers, Pradeep P. A. Mammen, Lin Xu, Rhonda Bassel-Duby, Ning Liu, Eric N. Olson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The nuclear envelope tethers chromatin to the nuclear periphery to control genome architecture. Here, the authors show that Net39 preserves the integrity and gene expression of muscle nuclei in mice, and it may contribute to the pathogenesis of Emery
Externí odkaz:
https://doaj.org/article/3a056dc3d882494d8fb0ecf911b951c9