Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Chunwei Cheng"'
Autor:
Chunwei Cheng, Yan Liu, Maria E. Balasis, Thomas P. Garner, Jerry Li, Nicholas L. Simmons, Norbert Berndt, Hao Song, Lili Pan, Yong Qin, K. C. Nicolaou, Evripidis Gavathiotis, Said M. Sebti, Rongshi Li
Publikováno v:
Marine Drugs, Vol 12, Iss 8, Pp 4311-4325 (2014)
A series of novel marinopyrroles with sulfide and sulphone spacers were designed and synthesized. Their activity to disrupt the binding of the pro-apoptotic protein, Bim, to the pro-survival proteins, Mcl-1 and Bcl-xL, was evaluated using ELISA assay
Externí odkaz:
https://doaj.org/article/255b8c59125a43fea4568f61c9ee8827
Autor:
Chunwei Cheng, Yan Liu, Maria E. Balasis, Nicholas L. Simmons, Jerry Li, Hao Song, Lili Pan, Yong Qin, K. C. Nicolaou, Said M. Sebti, Rongshi Li
Publikováno v:
Marine Drugs, Vol 12, Iss 3, Pp 1335-1348 (2014)
A series of novel cyclic marinopyrroles were designed and synthesized. Their activity to disrupt the binding of the pro-apoptotic protein, Bim, to the pro-survival proteins, Mcl-1 and Bcl-xL, was evaluated using ELISA assays. Both atropisomers of mar
Externí odkaz:
https://doaj.org/article/3e3a58f6df074c149931498cfd008993
Publikováno v:
Marine Drugs, Vol 11, Iss 8, Pp 2927-2948 (2013)
Methicillin-resistant Staphylococcus aureus (MRSA) continues to be a major problem, causing severe and intractable infections worldwide. MRSA is resistant to all beta-lactam antibiotics, and alternative treatments are limited. A very limited number o
Externí odkaz:
https://doaj.org/article/14b94ace4ba640deb50dee117e849075
Publikováno v:
Life Sciences. 209:157-166
Aims Gut inflammation has been put forward to be associated with hepatic injury in the clinical practice. The dismantled intestinal barrier was highly concerned, however, largely unknown about the role of gut-vascular barrier (GVB) in this process. T
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1862:337-350
Sterol regulatory element-binding protein 2 (SREBP-2), is a well-known transcriptional regulator of cholesterol metabolism. SREBP-2 is activated unconventionally to promote excessive cholesterol accumulation in non-alcoholic fatty liver disease (NAFL
Publikováno v:
Molecular Medicine Reports. 14:5751-5759
Liver fibrosis is a reversible wound‑healing response to liver damage. Following liver injury, activated hepatic stellate cells (HSCs) cause excessive deposition of collagen and other components of the extracellular matrix, which may eventually imp
Publikováno v:
International Journal of Molecular Medicine. 38:521-528
Phosphorylated cAMP-responsive element binding protein-1 (p-CREB-1) is an important transcription factor which has been reported to be implicated in fibrogenesis. However, the association between p-CREB-1 and transforming growth factor-β1 (TGF-β1)-
Autor:
Chunwei Cheng, Min Zhang, Shuqing Wang, Qilong Zhou, Yong Qin, Pei Tang, Dan Zhang, Chao Yang, Wentao Liu, Hao Song, Xiang Dai
Publikováno v:
The Journal of Organic Chemistry. 81:162-184
The practical formal synthesis of the anticoagulant drug fondaparinux sodium 1 was accomplished using an optimized modular synthetic strategy. The important pentasaccharide 2, a precursor for the synthesis of fondaparinux sodium, was synthesized on a
Publikováno v:
Experimental and Therapeutic Medicine
Inflammatory bowel diseases (IBDs), including ulcerative colitis (UC) and Crohn's disease (CD), are chronic inflammatory disorders caused by genetic influences, the immune system and environmental factors. However, the underlying pathogenesis of IBDs
Publikováno v:
International Journal of Molecular Medicine
Sterol regulatory element binding protein-2 (SREBP-2) is an important transcription factor in lipid homeostasis. A previous study showed that SREBP-2 also activated autophagic genes during cell-sterol depletion. Alterations in autophagy are reported