Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Chunting Qi"'
Autor:
Ying Qin, Dekang Li, Chunting Qi, Huaijiang Xiang, Huyan Meng, Jingli Liu, Shaoqing Zhou, Xinyu Gong, Ying Li, Guifang Xu, Rui Zu, Hang Xie, Yechun Xu, Gang Xu, Zheng Zhang, Shi Chen, Lifeng Pan, Li Tan
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 1, Pp 319-334 (2024)
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) functions as a key regulator in inflammation and cell death and is involved in mediating a variety of inflammatory or degenerative diseases. A number of allosteric RIPK1 inhibitors (RIPK1
Externí odkaz:
https://doaj.org/article/d923a9cf0f7544d983270d45a93222cd
Autor:
Dimitry Ofengeim, Yasushi Ito, Ayaz Najafov, Yaoyang Zhang, Bing Shan, Judy Park DeWitt, Juanying Ye, Xumin Zhang, Ansi Chang, Helin Vakifahmetoglu-Norberg, Jiefei Geng, Benedicte Py, Wen Zhou, Palak Amin, Jonilson Berlink Lima, Chunting Qi, Qiang Yu, Bruce Trapp, Junying Yuan
Publikováno v:
Cell Reports, Vol 10, Iss 11, Pp 1836-1849 (2015)
Multiple sclerosis (MS), a common neurodegenerative disease of the CNS, is characterized by the loss of oligodendrocytes and demyelination. Tumor necrosis factor α (TNF-α), a proinflammatory cytokine implicated in MS, can activate necroptosis, a ne
Externí odkaz:
https://doaj.org/article/0178a95c3a344ac1b03cbe265055d0cc
Autor:
Tao Zhang, Kangyun Dong, Wei Liang, Daichao Xu, Hongguang Xia, Jiefei Geng, Ayaz Najafov, Min Liu, Yanxia Li, Xiaoran Han, Juan Xiao, Zhenzhen Jin, Ting Peng, Yang Gao, Yu Cai, Chunting Qi, Qing Zhang, Anyang Sun, Marta Lipinski, Hong Zhu, Yue Xiong, Pier Paolo Pandolfi, He Li, Qiang Yu, Junying Yuan
Publikováno v:
eLife, Vol 4 (2015)
Autophagy is an important intracellular catabolic mechanism involved in the removal of misfolded proteins. Atg14L, the mammalian ortholog of Atg14 in yeast and a critical regulator of autophagy, mediates the production PtdIns3P to initiate the format
Externí odkaz:
https://doaj.org/article/3e868138a8c44057ad78966bdd7397e1
Autor:
Shengyuan Zhang, Liang Li, Gang Xu, Junying Yuan, Yang Liu, Zheng Zhang, Yunyun Wang, Dekang Li, Jizhou Gou, Jing Qu, Ping Zhao, Zhuohao He, Liang Liu, Tongyang Xiao, Guowei Wu, Kangyun Dong, Chunting Qi, Taijie Jin, Ying Li, Yilun Tong, Haoran Peng
Publikováno v:
Cell Research
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the ongoing global pandemic that poses substantial challenges to public health worldwide. A subset of COVID-19 patients experience systemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f77a63a4d966a9c76bb02a1565e87aaa
https://doi.org/10.1038/s41422-021-00578-7
https://doi.org/10.1038/s41422-021-00578-7
Autor:
Lingli Tan, Hengyue Shan, Chao Han, Zhenfeng Zhang, Jiali Shen, Xiao Zhang, Huaijiang Xiang, Kuankuan Lu, Chunting Qi, Ying Li, Guanglei Zhuang, Gang Chen, Li Tan
Publikováno v:
Journal of medicinal chemistry. 65(20)
Deubiquitinating enzymes (DUBs) are key regulatory components of the ubiquitination system. Many DUBs have been revealed to play key roles in normal physiology and diseases. However, only very limited DUB members have well-characterized inhibitors. O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eb931c9cdff0731a01b07cb954c22ef
https://pubmed.ncbi.nlm.nih.gov/36221183
https://pubmed.ncbi.nlm.nih.gov/36221183
Autor:
Lifeng Lin, Kaixuan Shi, Shaoqing Zhou, Mei-Chun Cai, Caiyan Zhang, Yunheng Sun, Jingyu Zang, Lin Cheng, Kaiyan Ye, Pengfei Ma, Peiye Shen, Meiying Zhang, Yan Cheng, Chunting Qi, Ying Li, Xia Yin, Yiyan Zheng, Li Tan, Guanglei Zhuang, Rongyu Zang
Publikováno v:
Oncogene. 41(12)
Müllerian tissue-specific oncogenes, prototyped by PAX8, underlie ovarian tumorigenesis and represent unique molecular vulnerabilities. Further delineating such lineage-dependency factors and associated therapeutic implications would provide valuabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8885c973a1a34033ee1b5d40b2caaf19
https://pubmed.ncbi.nlm.nih.gov/35124696
https://pubmed.ncbi.nlm.nih.gov/35124696
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-13 (2019)
BMC Cancer
BMC Cancer
Background The receptor tyrosine kinases (RTKs) play critical roles in the development of cancers. Clear cell renal cell carcinoma (ccRCC) accounts for 75% of the RCC. The previous studies on the RTKs in ccRCCs mainly focused on their gene expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe97106db47ae3ce137de5dfef49c34d
https://doi.org/10.1186/s12885-019-6159-2
https://doi.org/10.1186/s12885-019-6159-2
Autor:
Qiang Yu, Junying Yuan, Chunting Qi, Xingyan Li, H. Wang, Dana E. Christofferson, Zhen Liu, Bing Shan, Guowei Wu, Huyan Meng, Taijie Jin, Ying Li
Publikováno v:
Proceedings of the National Academy of Sciences. 115
RIPK1 is a critical mediator of cell death and inflammation downstream of TNFR1 upon stimulation by TNFα, a potent proinflammatory cytokine involved in a multitude of human inflammatory and degenerative diseases. RIPK1 contains an N-terminal kinase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdd3ecac21663459c4cdda307a6ab5b7
https://doi.org/10.1073/pnas.1722013115
https://doi.org/10.1073/pnas.1722013115
Autor:
Ansi Chang, Palak Amin, Yaoyang Zhang, Junying Yuan, Bruce D. Trapp, Yasushi Ito, Qiang Yu, Helin Vakifahmetoglu-Norberg, Judy Park DeWitt, Bénédicte F. Py, Jonilson Berlink Lima, Wen Zhou, Bing Shan, Ayaz Najafov, Xumin Zhang, Jiefei Geng, Chunting Qi, Juanying Ye, Dimitry Ofengeim
Publikováno v:
Cell Reports, Vol 10, Iss 11, Pp 1836-1849 (2015)
Cell Reports
Cell Reports, 2015, 10 (11), pp.1836-1849. ⟨10.1016/j.celrep.2015.02.051⟩
Cell Reports
Cell Reports, 2015, 10 (11), pp.1836-1849. ⟨10.1016/j.celrep.2015.02.051⟩
International audience; Multiple sclerosis (MS), a common neurodegenerative disease of the CNS, is characterized by the loss of oligodendrocytes and demyelination. Tumor necrosis factor α (TNF-α), a proinflammatory cytokine implicated in MS, can ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d94d68f9409c57d0075a8453e5a5291
https://doi.org/10.1016/j.celrep.2015.02.051
https://doi.org/10.1016/j.celrep.2015.02.051
Autor:
Qing Zhang, Jingli Liu, Jiawei Liu, Chunting Qi, Shan Kuang, Wuguo Li, Xiaoxiao Sun, Qiang Yu, Zhenhua Sima
Publikováno v:
Cancer Science
Constitutive activation of the signal transducer and activator of transcription 3 (STAT3) or the nuclear factor-κB (NF-κB) pathway occurs frequently in cancer cells and contributes to oncogenesis. The activation of Janus kinase 2 (JAK2) and IκB ki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a61cb6b4ffae4da737121094998ba553
https://doi.org/10.1111/cas.12359
https://doi.org/10.1111/cas.12359