Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Chunshen Long"'
Publikováno v:
Fundamental Research, Vol 4, Iss 4, Pp 770-776 (2024)
The increasing emergence of the time-series single-cell RNA sequencing (scRNA-seq) data, inferring developmental trajectory by connecting transcriptome similar cell states (i.e., cell types or clusters) has become a major challenge. Most existing com
Externí odkaz:
https://doaj.org/article/9c89d736ecd6420bb670483be9dbd822
Autor:
Chunshen Long, Hanshuang Li, Pengfei Liang, Lemuge Chao, Yan Hong, Junping Zhang, Qilemuge Xi, Yongchun Zuo
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 34, Iss , Pp 102044- (2023)
Single-cell studies have demonstrated that somatic cell reprogramming is a continuous process of cell fates transition. Only partial reprogramming intermediates can overcome the molecular bottlenecks to acquire pluripotency. To decipher the underlyin
Externí odkaz:
https://doaj.org/article/ecc85d5a3ff54f9791cf6d3cae0c4dbd
Publikováno v:
Research, Vol 6 (2023)
The precise characterization of cellular differentiation potency remains an open question, which is fundamentally important for deciphering the dynamics mechanism related to cell fate transition. We quantitatively evaluated the differentiation potenc
Externí odkaz:
https://doaj.org/article/2d698528a68b47d48c4a92f154c2927a
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 20, Iss , Pp 155-163 (2020)
Human preimplantation development is a complex process involving dramatic changes in transcriptional architecture. For a better understanding of their time-spatial development, it is indispensable to identify key genes. Although the single-cell RNA s
Externí odkaz:
https://doaj.org/article/cfbf509cccee438d8d6ff5872b542c6e
Publikováno v:
IEEE Access, Vol 7, Pp 7794-7802 (2019)
The identification of underlying differences is crucial for understanding the embryogenesis of species specificity. In this paper, a comparative transcriptome analysis of multi-species (CTAMS) was first developed to detect the genome activation diffe
Externí odkaz:
https://doaj.org/article/889939127d314633ad15483d5072fdfa
The spatial binding model of the pioneer factor Oct4 with its target genes during cell reprogramming
Autor:
Hanshuang Li, Na Ta, Chunshen Long, Qiutang Zhang, Siyu Li, Shuai liu, Lei Yang, Yongchun Zuo
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 17, Iss , Pp 1226-1233 (2019)
Understanding the target regulation between pioneer factor and its binding genes is crucial for improving the efficiency of TF-mediated reprogramming. Oct4 as the only one factor that cannot be substituted by other POU members, it is urgent need to d
Externí odkaz:
https://doaj.org/article/26c95d0d914f44ef97e9331d7818cb60
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 3, p 1567 (2022)
R-loop, a three-stranded RNA/DNA structure, plays important roles in modulating genome stability and gene expression, but the molecular mechanism of R-loops in cell reprogramming remains elusive. Here, we comprehensively profiled the genome-wide land
Externí odkaz:
https://doaj.org/article/0222cafc6dec42e7b98770df9258a9a7
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 15, p 8187 (2021)
Somatic cell nuclear transfer (SCNT) technology can reprogram terminally differentiated cell nuclei into a totipotent state. However, the underlying molecular barriers of SCNT embryo development remain incompletely elucidated. Here, we observed that
Externí odkaz:
https://doaj.org/article/63942c414cc44734bd1968133c71a5c7
Publikováno v:
Open Biology, Vol 9, Iss 6 (2019)
Understanding early development offers a striking opportunity to investigate genetic disease, stem cell and assisted reproductive technology. Recent advances in high-throughput sequencing technology have led to the rising influx of omics data, which
Externí odkaz:
https://doaj.org/article/4f06a439c4ed4c84a7f991d0a2017a5e
Autor:
Hongmei Bai, Shubin Li, Lirong Ma, Taji Bai, Gang Liu, Yongchun Zuo, Yuzhen Ma, Chunshen Long
Publikováno v:
Theriogenology. 177:11-21
Understanding the molecular level changes of oocyte cryopreservation and the subsequent warming process is essential for improving the oocyte cryopreservation technologies. Here, we collected the mature metaphase II (MII) oocytes from mice and vitrif