Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Chunnuan Wu"'
Autor:
Bole Li, Shan Liu, Honglei Feng, Chunshuang Du, Liman Wei, Jie Zhang, Guangwei Jia, Chunnuan Wu
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Backgrounds: Brain metastases occur in approximately 30% of patients with non-small-cell lung cancer (NSCLC). Therefore, the free drug concentration in cerebrospinal fluid (CSF) is strongly associated with the clinical efficacy.Purpose: The present s
Externí odkaz:
https://doaj.org/article/cb5a692eabfc4913adf2211582e45511
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
This study aimed to apply a physiologically based pharmacokinetic (PBPK) model to predict optimal dosing regimens of pazopanib (PAZ) for safe and effective administration when co-administered with CYP3A4 inhibitors, acid-reducing agents, food, and ad
Externí odkaz:
https://doaj.org/article/c0a05166d15043608da0d90a0cf87448
Autor:
Chunnuan Wu, Huining Liu, Shuang Yu, Congcong Ren, Jie Zhang, Guopeng Wang, Bole Li, Yang Liu
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 153, Iss , Pp 113509- (2022)
Background: This study aimed to build a mathematical model of physiologically based pharmacokinetic combined DPP-4 occupancy (PBPK-DO) in humans to provide some recommendations for dosing adjustment in patients with renal impairment. Methods: The PBP
Externí odkaz:
https://doaj.org/article/e37af1096b6c4dbba1e5bb882ac164fe
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2021)
Danggui Sini Decoction (DSD), a classic Chinese herb medicine (CHM) formula, has been used to treat various diseases in China for centuries. However, it remains challenging to reveal its mechanism of action through conventional pharmacological method
Externí odkaz:
https://doaj.org/article/5e2ea8a745394127848dde4b553d022c
Autor:
Zhenbao Li, Wenhui Tao, Dong Zhang, Chunnuan Wu, Binbin Song, Shang Wang, Tianyang Wang, Mingming Hu, Xiaohong Liu, Yongjun Wang, Yinghua Sun, Jin Sun
Publikováno v:
Asian Journal of Pharmaceutical Sciences, Vol 12, Iss 3, Pp 285-291 (2017)
A biodegradable poly(lactic-co-glycolic acid) loading atorvastatin calcium (AC) nanoparticles (AC-PLGA-NPs) were prepared by probe ultrasonication and evaporation method aiming at improving the oral bioavailability of AC. The effects of experimental
Externí odkaz:
https://doaj.org/article/722d80d9f3ea49b184f050689ba1bd71
Publikováno v:
Asian Journal of Pharmaceutical Sciences, Vol 12, Iss 1, Pp 98-104 (2017)
The aim of the present study was to investigate virtual population pharmacokinetic using physiologically based pharmacokinetic (PBPK) model for evaluating bioequivalence of oral lacidipine formulations in dogs. The dissolution behaviors of three laci
Externí odkaz:
https://doaj.org/article/b1a0082490aa4aa7bcbefe6a330a5814
Autor:
Zhenbao Li, Lei Shang, Chang Liu, Panqin Ma, Chunnuan Wu, Wenjuan Zhang, Yinghua Sun, Yongjun Wang, Xiaohong Liu, Jin Sun
Publikováno v:
Asian Journal of Pharmaceutical Sciences, Vol 11, Iss 5, Pp 641-647 (2016)
Combinational therapy of lamivudine and oxymatrine has been employed in the battle against hepatitis B virus in clinical setting. However, the pharmacokinetic behavior of the drug or active metabolism in intravenous/oral co-administration regime is p
Externí odkaz:
https://doaj.org/article/6de74f6c44a744289f23c77311402a71
Publikováno v:
Asian Journal of Pharmaceutical Sciences, Vol 10, Iss 1, Pp 57-63 (2015)
A limited number of researches have been reported to apply the Arrhenius equation to study the relationship between drugs and its degradation products so far. In the present work, the thermal degradation kinetics of lysine hydrochloride solutions for
Externí odkaz:
https://doaj.org/article/6dd9d6a97e0a4101a3e63f9a593a40ff
Publikováno v:
Bioengineered, Vol 13, Iss 2, Pp 2992-3006 (2022)
Osteosarcoma (OS), the most prevalent bone malignancy, mainly affects children and adolescents. Despite recent advances in multimodal therapy, the overall survival rate for OS patients remains poor. Chinese herb medicine (CHM) is an alternative thera
Autor:
Chunnuan Wu, Yuanhang Yang, Wenying Wu, Jing Li, Yingli Wang, Xiaoting Li, Weiping Wang, Qikun Jiang, Tianhong Zhang, Cong Luo, Huixin Li, Yu Zhang
Publikováno v:
Molecular Pharmaceutics. 16:3780-3790
A quantitative prediction of human pharmacokinetic (PK) profiles has become an increasing demand for the reduction of the clinical failure of drug formulations. The existing in vitro and in vivo correlation (IVIVC) methodology could achieve this goal