Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Chunkyu Ko"'
Autor:
Samuel D. Jeske, Jochen M. Wettengel, Florian Gegenfurtner, Konrad Fischer, Judith Moosmüller, Anindita Chakraborty, Chunkyu Ko, Benjamin J. Burwitz, Angelika Schnieke, Ulrike Protzer
Publikováno v:
npj Viruses, Vol 2, Iss 1, Pp 1-8 (2024)
Abstract With 254 million chronically infected patients, hepatitis B virus (HBV) continues to be a severe health threat. While animal models play a crucial role in developing new therapies, the availability of preclinical HBV models is very limited.
Externí odkaz:
https://doaj.org/article/d6de634fbf1c40c2909bd700f979d1df
Autor:
Charlotte Hedskog, Christoph D. Spinner, Ulrike Protzer, Dieter Hoffmann, Chunkyu Ko, Robert L. Gottlieb, Medhat Askar, Meta Roestenberg, Jutte J. C. de Vries, Ellen C. Carbo, Ross Martin, Jiani Li, Dong Han, Lauren Rodriguez, Aiyappa Parvangada, Jason K. Perry, Ricard Ferrer, Andrés Antón, Cristina Andrés, Vanessa Casares, Huldrych F. Günthard, Michael Huber, Grace A. McComsey, Navid Sadri, Judith A. Aberg, Harm van Bakel, Danielle P. Porter
Publikováno v:
Viruses, Vol 16, Iss 4, p 546 (2024)
Remdesivir (RDV) is a broad-spectrum nucleotide analog prodrug approved for the treatment of COVID-19 in hospitalized and non-hospitalized patients with clinical benefit demonstrated in multiple Phase 3 trials. Here we present SARS-CoV-2 resistance a
Externí odkaz:
https://doaj.org/article/96f39a75be5a4ab7bceddaed4be70324
Autor:
Samuel Hofmann, Verena Plank, Peter Groitl, Nathalie Skvorc, Katharina Hofmann, Julius Luther, Chunkyu Ko, Peter Zimmerman, Volker Bruss, Daniela Stadler, Arnaud Carpentier, Shahinda Rezk, Michael Nassal, Ulrike Protzer, Sabrina Schreiner
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 3 (2023)
ABSTRACT Persistence of hepatitis B virus (HBV) infection is due to a nuclear covalently closed circular DNA (cccDNA), generated from the virion-borne relaxed circular DNA (rcDNA) genome in a process likely involving numerous cell factors from the ho
Externí odkaz:
https://doaj.org/article/6e91a524171e45ca9719ff6aadbb1c3c
Publikováno v:
Molecules, Vol 26, Iss 24, p 7420 (2021)
Hepatitis B virus (HBV) is a major causative agent of human hepatitis. Its viral genome comprises partially double-stranded DNA, which is complexed with viral polymerase within an icosahedral capsid consisting of a dimeric core protein. Here, we desc
Externí odkaz:
https://doaj.org/article/9dfbb73afc724521ae5403a7ee9c2df6
Autor:
Katrin Manske, Annika Schneider, Chunkyu Ko, Percy A. Knolle, Katja Steiger, Ulrike Protzer, Dirk Wohlleber
Publikováno v:
Viruses, Vol 13, Iss 11, p 2273 (2021)
Immunity against hepatitis B virus (HBV) infection is complex and not entirely understood so far, including the decisive factors leading to the development of chronic hepatitis B. This lack of a mechanistic understanding of HBV-specific immunity is a
Externí odkaz:
https://doaj.org/article/4f515b1db01a4d0f9470d29af1867d8b
Autor:
Benjamin J. Burwitz, Jochen M. Wettengel, Martin A. Mück-Häusl, Marc Ringelhan, Chunkyu Ko, Marvin M. Festag, Katherine B. Hammond, Mina Northrup, Benjamin N. Bimber, Thomas Jacob, Jason S. Reed, Reed Norris, Byung Park, Sven Moller-Tank, Knud Esser, Justin M. Greene, Helen L. Wu, Shaheed Abdulhaqq, Gabriela Webb, William F. Sutton, Alex Klug, Tonya Swanson, Alfred W. Legasse, Tania Q. Vu, Aravind Asokan, Nancy L. Haigwood, Ulrike Protzer, Jonah B. Sacha
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Hepatitis B virus (HBV) has a limited host range and current animal models can only recapitulate certain aspects of HBV replication. Here, the authors show that expression of the HBV receptor NTCP in macaques supports HBV replication in vivo, suggest
Externí odkaz:
https://doaj.org/article/2039d96647514d3c9a3deb587404ab5a
Autor:
Thomas Michler, Stefanie Große, Stefan Mockenhaupt, Natalie Röder, Ferdinand Stückler, Bettina Knapp, Chunkyu Ko, Mathias Heikenwalder, Ulrike Protzer, Dirk Grimm
Publikováno v:
EMBO Molecular Medicine, Vol 8, Iss 9, Pp 1082-1098 (2016)
Abstract Hepatitis B virus (HBV) is a promising target for therapies based on RNA interference (RNAi) since it replicates via RNA transcripts that are vulnerable to RNAi silencing. Clinical translation of RNAi technology, however, requires improvemen
Externí odkaz:
https://doaj.org/article/cc0d7efac0984a2bb0526ab75c1cabdd
Autor:
Wen-Min Chou, Daniela Stadler, Jochen M. Wettengel, Chunkyu Ko, Shanshan Luo, Elfriede Noeßner, Ulrike Protzer, Jan Hendrik Bockmann, Zhe Xie, Lili Zhao, Oliver Quitt, Nadja Bulbuc, Forough Golsaz-Shirazi, Gerhard Moldenhauer, Julia Festag, Raindy Tedjokusumo, Mathias Heikenwalder, Felix Bohne, Frank Momburg, Eva Loffredo-Verde, Marten Meyer, Sandra Lüttgau, Fazel Shokri
Publikováno v:
J. Hepatol. 75, 1058-1071 (2021)
BACKGROUND & AIMS: Hepatitis B virus (HBV) infection is a global health threat responsible for 880,000 deaths per year. Current antiviral therapies control but rarely eliminate the virus, and leave chronic HBV carriers at risk to develop hepatocellul
Autor:
Lena Allweiss, Barbara Testoni, Mei Yu, Julie Lucifora, Chunkyu Ko, Bingqian Qu, Marc Lütgehetmann, Haitao Guo, Stephan Urban, Simon P Fletcher, Ulrike Protzer, Massimo Levrero, Fabien Zoulim, Maura Dandri
ObjectivesA major goal of curative hepatitis B virus (HBV) treatments is the reduction or inactivation of intrahepatic viral covalently closed circular DNA (cccDNA). Hence, precise cccDNA quantification is essential in preclinical and clinical studie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee3a82c3eb8247a5fdbbf74e50a33cbc
https://mediatum.ub.tum.de/doc/1696454/document.pdf
https://mediatum.ub.tum.de/doc/1696454/document.pdf
Publikováno v:
Antiviral Research. 213:105591