Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Chunhui Hou"'
Publikováno v:
GCB Bioenergy, Vol 16, Iss 7, Pp n/a-n/a (2024)
Abstract Light is a critical environmental signal that is perceived by various photoreceptors and is of great significance in the photosynthetic growth of algae and plants. The phytochrome‐lacking model green alga Chlamydomonas reinhardtii possesse
Externí odkaz:
https://doaj.org/article/92771ff38f094f72a38bfb946052017e
Autor:
Li Cheng, Shijun Zhao, Tianyi Li, Sha Hou, Zhouqing Luo, Jinsheng Xu, Wenfei Yu, Shuangying Jiang, Marco Monti, Daniel Schindler, Weimin Zhang, Chunhui Hou, Yingxin Ma, Yizhi Cai, Jef D. Boeke, Junbiao Dai
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Synthetic Chromosome Rearrangement and Modification by LoxP-mediated Evolution (SCRaMbLE) is a promising tool to study genomic rearrangements. However, the potential of SCRaMbLE to study genomic rearrangements is currently hindered, because
Externí odkaz:
https://doaj.org/article/55e225a83ac445e9b633a57718802700
Autor:
Jia-Yong Zhong, Longjian Niu, Zhuo-Bin Lin, Xin Bai, Ying Chen, Feng Luo, Chunhui Hou, Chuan-Le Xiao
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Here the authors establish a high throughput Pore-C (HiPore-C) method increasing the sequencing output of multi-way chromatin contacts and reveal single-allele topology diversity and cell type-specificity of 3D genome folding.
Externí odkaz:
https://doaj.org/article/fbc2c3b1c4364542a408df7a4501c1b7
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-11 (2022)
Abstract The pluripotency of naïve mouse embryonic stem cells (mES) is regulated by multiple signaling pathways, with inhibition of protein kinase C (PKCi) playing a particularly important role in maintaining naïve mES. However, the regulatory func
Externí odkaz:
https://doaj.org/article/13ba459e2be1406d99e2cd63f4aeea91
Autor:
Yinqiao Wu, Yuedong Zhang, Hang Liu, Yun Gao, Yuyan Liu, Ling Chen, Lu Liu, David M. Irwin, Chunhui Hou, Zhongyin Zhou, Yaping Zhang
Publikováno v:
Journal of Animal Science and Biotechnology, Vol 13, Iss 1, Pp 1-13 (2022)
Abstract Background The pig is an economically important livestock species and is a widely applied large animal model in medical research. Enhancers are critical regulatory elements that have fundamental functions in evolution, development and diseas
Externí odkaz:
https://doaj.org/article/2f5314753f294ae5b51206defa572f31
Autor:
Zhaoying Shi, Jinsheng Xu, Longjian Niu, Wei Shen, Shuting Yan, Yongjun Tan, Xuebo Quan, Edwin Cheung, Kai Huang, Yonglong Chen, Li Li, Chunhui Hou
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112151- (2023)
Summary: Transposable elements (TEs) are abundant in metazoan genomes and have multifaceted effects on host fitness. However, the mechanisms underlying the functions of TEs are still not fully understood. Here, we combine Hi-C, ATAC-seq, and ChIP-seq
Externí odkaz:
https://doaj.org/article/c5ea80c57a604a68966ea98014a386d6
Publikováno v:
Biology, Vol 12, Iss 9, p 1203 (2023)
The recently emerging high-throughput Pore-C (HiPore-C) can identify whole-genome high-order chromatin multi-way interactions with an ultra-high output, contributing to deciphering three-dimensional (3D) genome organization. However, it also brings n
Externí odkaz:
https://doaj.org/article/4392fefccd734e11bee3ec6bd88cf2d9
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
A/B compartments are observed in Hi-C data and coincide with eu/hetero-chromatin. However, many genomic regions are ambiguous under A/B compartment scheme. We develop MOSAIC (MOdularity and Singular vAlue decomposition-based Identification of Compart
Externí odkaz:
https://doaj.org/article/6c82509ea3f842c78a2cebd86db868ec
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Negative regulatory elements (NREs) down-regulate gene expression by inhibiting the activities of promoters or enhancers. The repressing activity of NREs can be measured globally by massively parallel reporter assays (MPRAs). However, most existing a
Externí odkaz:
https://doaj.org/article/edc9067006cd427daf45a50c87cd8bb7
Autor:
Jialei Sun, Na He, Longjian Niu, Yingzhang Huang, Wei Shen, Yuedong Zhang, Li Li, Chunhui Hou
Publikováno v:
Genomics, Proteomics & Bioinformatics, Vol 17, Iss 2, Pp 140-153 (2019)
Enhancers activate transcription in a distance-, orientation-, and position-independent manner, which makes them difficult to be identified. Self-transcribing active regulatory region sequencing (STARR-seq) measures the enhancer activity of millions
Externí odkaz:
https://doaj.org/article/926118e613f44921b4a461dbcb2a5d77