Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Chunhua, Wan"'
Publikováno v:
Cells, Vol 11, Iss 19, p 3017 (2022)
Besides the canonical function in ribosome biogenesis, there have been significant recent advances towards the fascinating roles of the nucleolus in stress response, cell destiny decision and disease progression. Nucleolar stress, an emerging concept
Externí odkaz:
https://doaj.org/article/17e78d1ba1494741ae115a6184f5e0b1
Publikováno v:
Cells, Vol 9, Iss 9, p 2125 (2020)
The Wnt/β-catenin signaling pathway exerts integral roles in embryogenesis and adult homeostasis. Aberrant activation of the pathway is implicated in growth-associated diseases and cancers, especially as a key driver in the initiation and progressio
Externí odkaz:
https://doaj.org/article/05ef0cbb6381439a9ba331ca3fa598a5
Perfluorooctane sulfonate aggravates CCl4 ‐induced hepatic fibrosis via HMGB1 / TLR4 /Smad signaling
Autor:
Chunhua Wan, Tianye Gu, Junyi Ling, Yi Qin, Jiashan Luo, Lingli Sun, Lu Hua, Jianya Zhao, Shengyang Jiang
Publikováno v:
Environmental Toxicology. 37:983-994
Perfluorooctane sulfonate (PFOS) is a widespread environmental pollutant and may cause a variety of adverse health effects. The hepatotoxicity of PFOS has attracted particular attention, given the fact that the liver has one of the highest PFOS accum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c79b60772053aafc202a0b93c364211a
https://doi.org/10.1002/tox.23458
https://doi.org/10.1002/tox.23458
Autor:
Shengyang Jiang, Baoying Hu, Tianye Gu, Junyi Ling, Lu Hua, Jianya Zhao, Jiashan Luo, Yi Qin, Chunhua Wan
Publikováno v:
Journal of applied toxicology : JATREFERENCES. 42(5)
Perfluorooctane sulfonate (PFOS) is a fluorinated organic pollutant with substantial accumulation in mammalian liver tissues. However, the impact of chronic PFOS exposure on liver disease progression and the underlying molecular mechanisms remain elu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ce15a4c29dde03a760717870eac5111
https://pubmed.ncbi.nlm.nih.gov/34687223
https://pubmed.ncbi.nlm.nih.gov/34687223
Publikováno v:
Folia Histochemica et Cytobiologica. 57:168-178
Introduction. Sepsis-induced acute lung injury (ALI) is an inflammatory process involved with simultaneous production of inflammatory cytokines and chemokines. In this study, we investigated the regulatory role of miR-539-5p in sepsis-induced ALI usi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93fd7ca218466a3b2721b33c95a563fc
https://doi.org/10.5603/fhc.a2019.0019
https://doi.org/10.5603/fhc.a2019.0019
Autor:
Hui Kheng Chua, Yue Li, Anh Doan, Jolanta Grembecka, Chunhua Wan, Sylvia Mahara, Ron Firestein, Claire Sun, Tomasz Cierpicki, Danxi Zhu, Dakang Xu, Dhanya Sooraj, Jia Bian
Publikováno v:
Science Advances
Genome-scale CRISPR screen identifies KMT2A as a druggable target against Wnt/β-catenin signaling and colorectal cancer.
Aberrant activation of Wnt/β-catenin pathway is a key driver of colorectal cancer (CRC) growth and of great therapeutic im
Aberrant activation of Wnt/β-catenin pathway is a key driver of colorectal cancer (CRC) growth and of great therapeutic im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a6264a0d2046a97f5e0ba451bbfa8fb
http://europepmc.org/articles/PMC8133758
http://europepmc.org/articles/PMC8133758
Autor:
Dhanya Sooraj, Claire Sun, Anh Doan, Daniel J. Garama, Marius V. Dannappel, Danxi Zhu, Hui K. Chua, Sylvia Mahara, Wan Amir Wan Hassan, Yeng Kwang Tay, Aleks Guanizo, Daniel Croagh, Zdenka Prodanovic, Daniel J. Gough, Chunhua Wan, Ron Firestein
Publikováno v:
Molecular cell. 82(1)
Mediator kinases (CDK8/19) are transcriptional regulators broadly implicated in cancer. Despite their central role in fine-tuning gene-expression programs, we find complete loss of CDK8/19 is tolerated in colorectal cancer (CRC) cells. Using orthogon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::859dc4518ae3072b4f26d28be85d9726
https://pubmed.ncbi.nlm.nih.gov/34995505
https://pubmed.ncbi.nlm.nih.gov/34995505
Publikováno v:
Cancers. 14:3722
Our understanding of the fascinating connection between nervous system and gastrointestinal (GI) tumorigenesis has expanded greatly in recent years. Recent studies revealed that neurogenesis plays an active part in GI tumor initiation and progression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1c7a5405a53052deb674697a3f835fa
https://doi.org/10.3390/cancers14153722
https://doi.org/10.3390/cancers14153722
Autor:
Chunhua Wan, Jiao Liu, Xiaoke Nie, Jianya Zhao, Songlin Zhou, Zhiqing Duan, Cuiying Tang, Lingwei Liang, Guangfei Xu
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89811 (2014)
The widespread environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a potent toxicant that causes significant neurotoxicity. However, the biological events that participate in this process remain largely elusive. In the present study
Externí odkaz:
https://doaj.org/article/9582cfab5d2b4273a43bf78ebc8357b6
Autor:
Lishuai Qu, Runzhou Ni, Mingbing Xiao, Yihui Fan, Chunhua Wan, Jinxia Liu, Feng Jiang, Wenkai Ni, Cuihua Lu
Publikováno v:
Oncogenesis
Oncogenesis, Vol 9, Iss 9, Pp 1-14 (2020)
Oncogenesis, Vol 9, Iss 9, Pp 1-14 (2020)
β-Adrenergic receptor (β-AR) signalling is strongly associated with tumour progression by the coupling of β-ARs with either a G protein or β-arrestin; however, the related mechanism underlying hepatocellular carcinoma (HCC) metastasis is not clea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c673f9b78e5825946696650236406034
http://europepmc.org/articles/PMC7515897
http://europepmc.org/articles/PMC7515897