Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Chunhong Long"'
Autor:
Chunhong Long, Peihao Huang
Publikováno v:
Molecules, Vol 29, Iss 13, p 3155 (2024)
In recent years, the photoelectric conversion efficiency of three–dimensional (3D) perovskites has seen significant improvements. However, the commercial application of 3D perovskites is hindered by stability issues and the toxicity of lead. Two–
Externí odkaz:
https://doaj.org/article/8d8416fb98b44fa1ac153c1831692fcc
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 3339-3348 (2021)
Designing antiviral therapeutics is of great concern per current pandemics caused by novel coronavirus or SARS-CoV-2. The core polymerase enzyme in the viral replication/transcription machinery is generally conserved and serves well for drug target.
Externí odkaz:
https://doaj.org/article/94f1f0638e934db4936fb90e3fc959dc
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 17, Iss , Pp 638-644 (2019)
RNA polymerase (RNAP) from bacteriophage T7 is a representative single-subunit viral RNAP that can transcribe with high promoter activities without assistances from transcription factors. We accordingly studied this small transcription machine comput
Externí odkaz:
https://doaj.org/article/18757a37fb404090991c3d93d6816477
Autor:
Chenggong Ji, Shuo Du, Peng Li, Qinyu Zhu, Xiaoke Yang, Chunhong Long, Jin Yu, Feng Shao, Junyu Xiao
Publikováno v:
PLoS Pathogens, Vol 15, Iss 6, p e1007876 (2019)
The guanylate-binding proteins (GBPs) belong to the dynamin superfamily of GTPases and function in cell-autonomous defense against intracellular pathogens. IpaH9.8, an E3 ligase from the pathogenic bacterium Shigella flexneri, ubiquitinates a subset
Externí odkaz:
https://doaj.org/article/aebbe7f74fb24a8093edc7229b92f76a
Autor:
Chunhong Long, Jin Yu
Publikováno v:
Entropy, Vol 20, Iss 4, p 306 (2018)
High fidelity gene transcription and replication require kinetic discrimination of nucleotide substrate species by RNA and DNA polymerases under chemical non-equilibrium conditions. It is known that sufficiently large free energy driving force is nee
Externí odkaz:
https://doaj.org/article/12c3a75343e44dc3ab40d6def2f6f58f
Publikováno v:
Physical Chemistry Chemical Physics. 25:13508-13520
The relative binding free energies between RTP and ATP are calculated.
Autor:
Chunhong Long, Anusha Mysore Keerthi, Dajun Xu, Jin Yu, Daniel La Rocco, Moises Ernesto Romero
Publikováno v:
Molecular Systems Design and Engineering, vol 6, iss 11
Molecular Systems Design & Engineering, vol 6, iss 11
Molecular Systems Design & Engineering, vol 6, iss 11
Remdesivir (RDV) prodrug can be metabolized into a triphosphate form nucleotide analogue (RDV-TP) to bind and insert into the active site of viral RNA dependent RNA polymerase (RdRp) to further interfere with viral genome replication. In this work, w
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 3339-3348 (2021)
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal
Designing antiviral therapeutics is of great concern per current pandemics caused by novel coronavirus or SARS-CoV-2. The core polymerase enzyme in the viral replication/transcription machinery is generally conserved and serves well for drug target.
Autor:
Chunhong Long, Quan Li, Yanming Ma, Hanyu Liu, Russell J. Hemley, Peihao Huang, Yanchao Wang, Jian Lv, Changfeng Chen
Publikováno v:
Proc Natl Acad Sci U S A
The anomalous nondipolar and nonaxisymmetric magnetic fields of Uranus and Neptune have long challenged conventional views of planetary dynamos. A thin-shell dynamo conjecture captures the observed phenomena but leaves unexplained the fundamental mat
Publikováno v:
Nucleic Acids Research
An elongation cycle of a transcribing RNA polymerase (RNAP) usually consists of multiple kinetics steps, so there exist multiple kinetic checkpoints where non-cognate nucleotides can be selected against. We conducted comprehensive free energy calcula