Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Chungang Gu"'
Publikováno v:
Frontiers in Physiology, Vol 12 (2022)
BackgroundPostoperative risk stratification is challenging in patients with ST-segment elevation myocardial infarction (STEMI) who undergo percutaneous coronary intervention. This study aimed to characterize the metabolic fingerprints of patients wit
Externí odkaz:
https://doaj.org/article/1b953882d77e461db049f6205b6c4f4f
Autor:
Tieguang Yao, Liangwei Wu, Craig S. Donald, Douglas Ferguson, Lei Wang, Andrew Pike, Jianyan Wang, Justin Cidado, Dedong Wu, Kurt Gordon Pike, Kumar Thakur, Chungang Gu, Calum Cook, James Horstick, Tyler Grebe, Theresa Proia, Darren Stead, Alexander Hird, Michelle Lamb, Wenlin Shao, Nichole O'Connell, Yun Jiang, Sudhir M. Hande, Bin Yang, Janet Hawkins, Barlaam Bernard Christophe, Neil Sumner, Melissa Vasbinder, Andrew D. Ferguson, Jane E. Moore, Jeffrey G. Varnes, Bryan Roberts, Maryann San Martin, Lisa Drew, Ujjal Sarkar, Allan Dishington, Chris De Savi, Robert Casella, Steve C. Glossop, Jane L. Holmes, Thomas M. McGuire
Publikováno v:
Journal of Medicinal Chemistry. 63:15564-15590
A CDK9 inhibitor having short target engagement would enable a reduction of Mcl-1 activity, resulting in apoptosis in cancer cells dependent on Mcl-1 for survival. We report the optimization of a series of amidopyridines (from compound 2), focusing o
Vixotrigine is a voltage- and use-dependent sodium channel blocker under investigation for the potential treatment of neuropathic pain. One of the major in vivo metabolic pathways of vixotrigine in humans is the hydrolysis of the carboxamide to form
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2525597e0f4f84ec1c1b003f86402a3
Autor:
Bin Ma, Urjana Poreci, Luisette Delva, Fengmei Zhang, Hao Tang, Tonika Bohnert, Patricia Schroeder, Richard Grater, Sudarshan Kapadnis, Kris King, Michael Mingueneau, Marc Hoemberger, Evelyne Polack, Brian T. Hopkins, Prince Robin, Chris Rowbottom, Robert Meissner, Eris Bame, Joseph C Santoro, Paramasivam Murugan, Allie M Roach, Claire M. Metrick, Kevin L. Otipoby, Eric Tien, Josh Johnson, Douglas Donaldson, Joseph P. Lyssikatos, Doug Burdette, Tom Magee, Carrie Boiselle, Chungang Gu, Mukesh Lulla, Bekim Bajrami, Jeremy C. Burns, Cheryl Black, Marx Isaac
Publikováno v:
Journal of medicinal chemistry. 65(2)
Multiple Sclerosis is a chronic autoimmune neurodegenerative disorder of the central nervous system (CNS) that is characterized by inflammation, demyelination, and axonal injury leading to permeant disability. In the early stage of MS, inflammation i
Autor:
Bin Ma, Claire M. Metrick, Chungang Gu, Marc Hoemberger, Bekim Bajrami, Eris Bame, Jiansheng Huang, Michael Mingueneau, Paramasivam Murugan, Joseph C. Santoro, Hao Tang, Ti Wang, Brian T. Hopkins
Publikováno v:
Bioorganicmedicinal chemistry letters. 60
BTK is a tyrosine kinase playing an important role in B cell and myeloid cell functions through B cell receptor (BCR) signaling and Fc receptor (FcR) signaling. Selective inhibition of BTK has the potential to provide therapeutical benefits to patien
Autor:
Lei Wang, Allan Dishington, Jane E. Moore, Kurt Gordon Pike, Wenlin Shao, Andrew Lister, Anil Patel, Lorraine A. Hassall, Sudhir M. Hande, Jane L. Holmes, Douglas Ferguson, Thomas M. McGuire, Jeffrey G. Varnes, Lin Xue, Chungang Gu, Tieguang Yao, Barlaam Bernard Christophe, Lisa Drew, Janet Hawkins, Liangwei Wu, Chris De Savi, Melissa Vasbinder, Andrew D. Ferguson, Darren Stead, Ujjal Sarkar, Michelle Lamb, Nichole O'Connell, Bin Yang, Alexander Hird
Publikováno v:
Journal of medicinal chemistry. 64(20)
Optimization of a series of azabenzimidazoles identified from screening hit 2 and the information gained from a co-crystal structure of the azabenzimidazole-based lead 6 bound to CDK9 led to the discovery of azaindoles as highly potent and selective
Publikováno v:
EPJ Techniques and Instrumentation, Vol 11, Iss 1, Pp 1-8 (2024)
Abstract HVE-400 ion implanter is special ion implantation equipment for semiconductor materials boron and phosphorus doping. The ion source and extraction deflection system are at high voltage platform, while the corresponding control system is at g
Externí odkaz:
https://doaj.org/article/c1c39d4fc8964f64a2d8cb968642585e
Autor:
Bin Ma, Claire M. Metrick, Chungang Gu, Marc Hoemberger, Bekim Bajrami, Eris Bame, Jiansheng Huang, Michael Mingueneau, Paramasivam Murugan, Marta Nevalainen, Joseph C. Santoro, Hao Tang, Ti Wang, Brian T. Hopkins
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 72:128856
Autor:
Cathy Muste, Chungang Gu
Publikováno v:
Drug Metabolism and Pharmacokinetics. 42:100433
Irreversible Bruton's tyrosine kinase (BTK) inhibitor drugs are designed to bind covalently to a free-thiol cysteine in the BTK protein active site. However, these reactive drugs bind to off-target proteins as well. In this study, seven BTK-inhibitor
Autor:
Xin Ma, Xueming Dong, Kawthar Z. Alzarieni, Hilkka I. Kenttämaa, Mckay W Easton, Jacob Milton, Chungang Gu, Joann P. Max
Publikováno v:
International Journal of Mass Spectrometry. 463:116551
The carboxylic acid functionality is among the many functionalities that drug metabolites, degradation products and impurities may contain. Therefore, analytical techniques that can be used to rapidly identify the carboxylic acid functionality are im