Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Chung-Nien Chang"'
Autor:
CHUNG-NIEN CHANG, 張中年
92
Since ring expansion of bicyclo〔2.2.1〕heptanone analogues have been widely applied to the preparation for precursors of natural products and derivatives, they are very important reactions in the organic synthesis. Herein, we are intereste
Since ring expansion of bicyclo〔2.2.1〕heptanone analogues have been widely applied to the preparation for precursors of natural products and derivatives, they are very important reactions in the organic synthesis. Herein, we are intereste
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/86bzp2
Autor:
Yi-Kun Chiang, Ting-Yueh Tsai, Chia-Hui Chien, Chung-Yu Huang, Kai-Chia Yeh, Tsu Hsu, Min-Hsien Wang, Ssu-Hui Wu, Yu-Sheng Chao, Yu-Wen Huang, Weir-Torn Jiaang, Xin Chen, Chung-Nien Chang, Chiung-Tong Chen, Su-Ying Wu, Chen-Lung Huang, Jai-Hong Cheng
Publikováno v:
Journal of the Chinese Chemical Society. 56:1048-1055
A number of pyrazole compounds reported in literatures elicit anti-hyperglycemic effects. By modifying the side chain of the heterocyclic skeleton, a new chemical class of DPP-IV inhibitors structurally derived from the (pyrazol-4-yl)-methylamine sca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fae6f1ae48fa35e75a61b61eff05179
https://doi.org/10.1002/jccs.200900152
https://doi.org/10.1002/jccs.200900152
Publikováno v:
The Journal of Organic Chemistry. 72:7034-7037
Reactions of camphor-, and camphene-derived formyl [2.2.1]bicyclic carbinols with Grignard and organolithium reagents afford the corresponding regio- and stereospecific alkyl/aryl [3.2.1]bicyclic diols. Some of these bicyclic diols have been treated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c79944b5a1c0e86dfbb209e75a7b2a3c
https://doi.org/10.1021/jo070730q
https://doi.org/10.1021/jo070730q
Autor:
Weir-Torn Jiaang, Chung Nien Chang, Chia Hui Chien, Hsin Yi Wu, Yu Kang Lo, Ssu Hui Wu, Hong Jen Lee, Chiung-Tong Chen, Min Hsien Wang, Hsing Pang Hsieh, Xin Chen, Tsu Hsu, Yu Wen Huang, Yu-Sheng Chao, Mohane Selvaraj Coumar, Chung Yu Huang, Ting Yueh Tsai
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:3268-3272
A series of substituted pyrrolidine-2,4-dicarboxylic acid amides were synthesized as potential antidiabetic agents, and many of them showed good in vitro DPP-IV inhibition (IC 50 = 2-250 nM) with selectivity over DPP-II, DPP8 and FAP enzymes. Selecte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a91798f54be5e15028fa2c0a950fd803
https://doi.org/10.1016/j.bmcl.2006.03.037
https://doi.org/10.1016/j.bmcl.2006.03.037
Autor:
Chung-Nien Chang, Yen-Ting Yeh, Ting-Yueh Tsai, Mohane Selvaraj Coumar, Hsu Tsu, Weir-Torn Jiaang, Su-Ying Wu, Ying-Ying Chang, Yuan-Shou Chen, Ke-Ta Lin, Shiow-Ju Lee, Ssu-Hui Wu, Wei Cheng Chen, Hsing Pang Hsieh, Yu-Sheng Chao, Hsin-Sheng Wang, Chiung-Tong Chen, Kuo-His Kao, I-Lin Lu, Chia-Hui Chien, Xin Chen
Publikováno v:
Journal of Medicinal Chemistry. 49:373-380
Dipeptidyl peptidase IV (DPP-IV) inhibitors are expected to become a new type of antidiabetic drugs. Most known DPP-IV inhibitors often resemble the dipeptide cleavage products, with a proline mimic at the P1 site. As off-target inhibitions of DPP8 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2331bd9789f263cefe4020c050cead5
https://doi.org/10.1021/jm0507781
https://doi.org/10.1021/jm0507781
Autor:
Xin Chen, Chung-Nien Chang, Weir-Torn Jiaang, Chia-Hui Chien, Sheng-Ping Chang, Su-Ying Wu, Yuan-Shou Chen, I-Lin Lu, Ying-Ying Chang, Tung-Wei Chen, Kuo-His Kao, Jai-Hong Cheng, Hsu Tsu, Shiow-Ju Lee
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:3271-3275
To find potent and selective inhibitors of dipeptidyl peptidase IV (DPP-IV), we synthesized a series of 2-cyanopyrrolidine with P2-site 4-substituted glutamic acid derivatives and tested their activities against DPP-IV, DPP8, and DPP-II. Analogues th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59753f44a83949364944362fd6e69f67
https://doi.org/10.1016/j.bmcl.2005.04.051
https://doi.org/10.1016/j.bmcl.2005.04.051
Publikováno v:
ChemInform. 39
Reactions of camphor-, and camphene-derived formyl [2.2.1]bicyclic carbinols with Grignard and organolithium reagents afford the corresponding regio- and stereospecific alkyl/aryl [3.2.1]bicyclic diols. Some of these bicyclic diols have been treated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ecdba10b1ec05ef49a50bbfc1bc0721
https://doi.org/10.1002/chin.200802056
https://doi.org/10.1002/chin.200802056
Autor:
Hsing Pang Hsieh, Yu-Sheng Chao, Yu-Wen Huang, Mohane Selvaraj Coumar, Weir-Torn Jiaang, Chia-Hung Han, Tsu Hsu, Chiung-Tong Chen, Ssu-Hui Wu, Jai-Hong Cheng, Li-Jen Hsu, Xin Chen, Chung-Nien Chang, Hsin-Yi Wu, Ting-Yueh Tsai, Chia-Hui Chien
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(5)
Based on the structures of NVP-DPP728 (1) and NVP-LAF237 (Vildagliptin, 2), three series of DPP-IV inhibitors were synthesized by linking substituted anilines, benzylamines, and phenylethylamines to (2S)-cyanopyrrolidine through a linker. More than 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39f9795bc4bdaecae72cfb1e93f35269
https://pubmed.ncbi.nlm.nih.gov/17194587
https://pubmed.ncbi.nlm.nih.gov/17194587
Publikováno v:
Journal of Organic Chemistry; 8/31/2007, Vol. 72 Issue 18, p7034-7037, 4p, 2 Diagrams, 2 Charts