Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Chung-Mao Pan"'
Autor:
Neal W. Sach, Michael R. Collins, Jie Wang, Chung-Mao Pan, Jason Ewanicki, Huichin Zhu, Justin M. Lopchuk, Jillian E. Spangler, Jeff Elleraas, Liher Prieto, Lara R. Malins, William Farrell, Olugbeminiyi O. Fadeyi, Kasper Fjelbye, James J. Mousseau, Robert M. Oliver, Ryan Gianatassio, James Bradow, Gary M. Gallego, Jason K. Smith, Yu Kawamata, Phil S. Baran, Thomas Andrew Brandt, Jinjiang Zhu
Publikováno v:
Journal of the American Chemical Society
Driven by the ever-increasing pace of drug discovery and the need to push the boundaries of unexplored chemical space, medicinal chemists are routinely turning to unusual strained bioisosteres such as bicyclo[1.1.1]pentane, azetidine, and cyclobutane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84b0bed21c60e34980a9b01bbdf27558
https://doi.org/10.1021/jacs.6b13229
https://doi.org/10.1021/jacs.6b13229
Autor:
Jacob T. Edwards, Chung-Mao Pan, Tian Qin, Yuki Yabe, Patrick L. Holland, Phil S. Baran, Myles W. Smith, Dongyoung Kim, Julian C. Lo, Jinghan Gui, Jessica Giacoboni, Sara Gutiérrez
Publikováno v:
Journal of the American Chemical Society
This Article details the development of the iron-catalyzed conversion of olefins to radicals and their subsequent use in the construction of C-C bonds. Optimization of a reductive diene cyclization led to the development of an intermolecular cross-co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbd45d6c7250666ec826425bae8d1aba
http://europepmc.org/articles/PMC5314431
http://europepmc.org/articles/PMC5314431
Autor:
Josep Cornella, Michael A. Schmidt, Martin D. Eastgate, Jie Wang, Chung-Mao Pan, Shuhei Kawamura, Phil S. Baran, Tian Qin, Ryan Gianatassio, Jacob T. Edwards
Publikováno v:
Journal of the American Chemical Society
A new transformation is presented that enables chemists to couple simple alkyl carboxylic acids with aryl zinc reagents under Ni-catalysis. The success of this reaction hinges on the unique use of redox-active esters that allow one to employ such der
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16dc35cdc5d9f8d02d36798d986106c6
http://europepmc.org/articles/PMC4768290
http://europepmc.org/articles/PMC4768290
Autor:
Jinghan Gui1, Chung-Mao Pan1, Ying Jin1, Tian Qin1, Lo, Julian C.1, Lee, Bryan J.1, Spergel, Steven H.2, Mertzman, Michael E.2, Pitts, William J.2, La Cruz, Thomas E.3, Schmidt, Michael A.3, Darvatkar, Nitin4, Natarajan, Swaminathan R.4, Baran, Phil S.1 pbaran@scripps.edu
Publikováno v:
Science. 5/22/2015, Vol. 348 Issue 6237, p886-891. 6p.
Autor:
Yuki Yabe, Yu Kawamata, Phil S. Baran, Martin D. Eastgate, Chung-Mao Pan, Rodrigo A. Rodriguez
Publikováno v:
Journal of the American Chemical Society
Unlike its other halogen atom siblings, the utility of chlorinated arenes and (hetero)arenes are twofold: they are useful in tuning electronic structure as well as acting as points for diversification via cross-coupling. Herein we report the inventio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67189391851f1db9f5b3a853438b8786
https://doi.org/10.1021/ja5031744
https://doi.org/10.1021/ja5031744
Autor:
Jinghan Gui, Michael R. Collins, Martha A. Ornelas, Phil S. Baran, Qianghui Zhou, Yoshihiro Ishihara, Aaron C. Burns, Yuki Yabe, Chung-Mao Pan
Publikováno v:
Journal of the American Chemical Society
A practical C–H functionalization method for the methylation of heteroarenes is presented. Inspiration from Nature’s methylating agent, S-adenosylmethionine (SAM), allowed for the design and development of zinc bis(phenylsulfonylmethanesulfinate)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6472df64c95ad276e085696778928a8c
http://europepmc.org/articles/PMC3988686
http://europepmc.org/articles/PMC3988686
Autor:
Shelli R. McAlpine, Seong Jong Kim, Chun-Chieh Lin, Chung-Mao Pan, Dimple P. Rananaware, Deborah M. Ramsey
Publikováno v:
Med. Chem. Commun.. 4:406-410
We report the synthesis, cytotoxicity, and phenotypic analysis of oxazole and thiazole containing fragments. Evaluating the optimal size and heterocycle for growth inhibition and apoptosis showed that activity required at least two thiazoles sequenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c2316ed9dba9fab9ea64074ae8d6f7c
https://doi.org/10.1039/c2md20291c
https://doi.org/10.1039/c2md20291c
Autor:
Chung-Mao Pan, Josep Cornella, Jacob T. Edwards, Michael A. Schmidt, Phil S. Baran, Tian Qin, Shuhei Kawamura, Martin D. Eastgate, Jie Wang, Ryan Gianatassio
Publikováno v:
ChemInform. 47
A new transformation is presented that enables chemists to couple simple alkyl carboxylic acids with aryl zinc reagents under Ni-catalysis. The success of this reaction hinges on the unique use of redox-active esters that allow one to employ such der
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::adad9c9b9c867b5acdf5bd5d411151f3
https://doi.org/10.1002/chin.201633068
https://doi.org/10.1002/chin.201633068
Autor:
Thomas Andrew Brandt, Jinjiang Zhu, Michael R. Collins, Huichin Zhu, Gary M. Gallego, Lara R. Malins, Phil S. Baran, Liher Prieto, Jie Wang, Justin M. Lopchuk, Ryan Gianatassio, Chung-Mao Pan, Neal W. Sach, Jillian E. Spangler
Publikováno v:
Science (New York, N.Y.). 351(6270)
Opening one ring to tack on another Curious chemists have long sought to learn just how tightly carbon atoms can be bound together. For instance, it's possible to form a bond between two opposite corners of an already strained four-membered ring to m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::526f31f6874cab6c130309081dde8a74
https://pubmed.ncbi.nlm.nih.gov/27001724
https://pubmed.ncbi.nlm.nih.gov/27001724