Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Chung-Jiuan Jeng"'
Autor:
Chang-Heng Hsieh, Chia-Cheng Chou, Ya-Ching Fang, Po-Hao Hsu, Yi-Hung Chiu, Chi-Sheng Yang, Guey-Mei Jow, Chih-Yung Tang, Chung-Jiuan Jeng
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-24 (2023)
Abstract Background Mutations in the human gene encoding the neuron-specific Eag1 (KV10.1; KCNH1) potassium channel are linked to congenital neurodevelopmental diseases. Disease-causing mutant Eag1 channels manifest aberrant gating function and defec
Externí odkaz:
https://doaj.org/article/c9fe821cf1bb4203a23a19546faaf519
Autor:
Yu-Ling Gan, Chen-Yu Wang, Rong-Heng He, Pei-Chien Hsu, Hsin-Hsien Yeh, Tsung-Han Hsieh, Hui-Ching Lin, Ming-Yen Cheng, Chung-Jiuan Jeng, Ming-Chyi Huang, Yi-Hsuan Lee
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-21 (2022)
Abstract Background Inflammation is a potential risk factor of mental disturbance. FKBP5 that encodes FK506-binding protein 51 (FKBP51), a negative cochaperone of glucocorticoid receptor (GR), is a stress-inducible gene and has been linked to psychia
Externí odkaz:
https://doaj.org/article/c879189580ec4a1f8000b3c9bf60c8c3
Autor:
Chung-Jiuan Jeng, Ssu-Ju Fu, Chia-Ying You, Yi-Jheng Peng, Cheng-Tsung Hsiao, Tsung-Yu Chen, Chih-Yung Tang
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
The voltage-dependent ClC-1 chloride channel, whose open probability increases with membrane potential depolarization, belongs to the superfamily of CLC channels/transporters. ClC-1 is almost exclusively expressed in skeletal muscles and is essential
Externí odkaz:
https://doaj.org/article/ff9b0382f8cd4703acbf7270b4cd1390
Autor:
Cheng-Tsung Hsiao, Thomas F. Tropea, Ssu-Ju Fu, Tanya M. Bardakjian, Pedro Gonzalez-Alegre, Bing-Wen Soong, Chih-Yung Tang, Chung-Jiuan Jeng
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 15, p 8247 (2021)
Loss-of-function mutations in the KV4.3 channel-encoding KCND3 gene are linked to neurodegenerative cerebellar ataxia. Patients suffering from neurodegeneration associated with iron deposition may also present with cerebellar ataxia. The mechanism un
Externí odkaz:
https://doaj.org/article/996c415dc9fb4ba39ba616c08338fe0b
Autor:
Ginevra Zanni, Cheng-Tsung Hsiao, Ssu-Ju Fu, Chih-Yung Tang, Alessandro Capuano, Luca Bosco, Federica Graziola, Emanuele Bellacchio, Serenella Servidei, Guido Primiano, Bing-Wen Soong, Chung-Jiuan Jeng
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 9, p 4986 (2021)
KCND3 encodes the voltage-gated potassium channel KV4.3 that is highly expressed in the cerebellum, where it regulates dendritic excitability and calcium influx. Loss-of-function KV4.3 mutations have been associated with dominant spinocerebellar atax
Externí odkaz:
https://doaj.org/article/15759d31a21342909ceea688dad5cfb8
Autor:
Ssu-Ju Fu, Meng-Chun Hu, Cheng-Tsung Hsiao, An-Ting Cheng, Tsung-Yu Chen, Chung-Jiuan Jeng, Chih-Yung Tang
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 11, p 5859 (2021)
The ClC-2 channel plays a critical role in maintaining ion homeostasis in the brain and the testis. Loss-of-function mutations in the ClC-2-encoding human CLCN2 gene are linked to the white matter disease leukodystrophy. Clcn2-deficient mice display
Externí odkaz:
https://doaj.org/article/5635a4bd71404a6ab9da2c8d61dd1767
Autor:
Ssu-Ju Fu, Meng-Chun Hu, Yi-Jheng Peng, Hsin-Yu Fang, Cheng-Tsung Hsiao, Tsung-Yu Chen, Chung-Jiuan Jeng, Chih-Yung Tang
Publikováno v:
Cells, Vol 9, Iss 6, p 1332 (2020)
Voltage-gated ClC-2 channels are essential for chloride homeostasis. Complete knockout of mouse ClC-2 leads to testicular degeneration and neuronal myelin vacuolation. Gain-of-function and loss-of-function mutations in the ClC-2-encoding human CLCN2
Externí odkaz:
https://doaj.org/article/8820b3f04a634771ac8403cf89d97a3e
Autor:
Yi-Jheng Peng, Yi-Ching Lee, Ssu-Ju Fu, Yun-Chia Chien, Yi-Fan Liao, Tsung-Yu Chen, Chung-Jiuan Jeng, Chih-Yung Tang
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 12, p 3783 (2018)
Mutations in the skeletal muscle-specific CLC-1 chloride channel are associated with the human hereditary disease myotonia congenita. The molecular pathophysiology underlying some of the disease-causing mutations can be ascribed to defective human CL
Externí odkaz:
https://doaj.org/article/c9c21f4d6820442883ee7bd7c34fd60a
Autor:
Ting-Feng Lin, Guey-Mei Jow, Hsin-Yu Fang, Ssu-Ju Fu, Hao-Han Wu, Mei-Miao Chiu, Chung-Jiuan Jeng
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e110423 (2014)
Eag (Kv10) and Erg (Kv11) belong to two distinct subfamilies of the ether-à-go-go K+ channel family (KCNH). While Erg channels are characterized by an inward-rectifying current-voltage relationship that results from a C-type inactivation, mammalian
Externí odkaz:
https://doaj.org/article/037ccebd39d8414480c1c3f2ef9c9351
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79350 (2013)
The astrocytic syncytium plays a critical role in maintaining the homeostasis of the brain through the regulation of gap junction intercellular communication (GJIC). Changes to GJIC in response to inflammatory stimuli in astrocytes may have serious e
Externí odkaz:
https://doaj.org/article/4cfc9bbce9b144fb9376bdbf05dccd76