Zobrazeno 1 - 10
of 350
pro vyhledávání: '"Chung-I Wu"'
Genomic evidence for rediploidization and adaptive evolution following the whole-genome triplication
Autor:
Xiao Feng, Qipian Chen, Weihong Wu, Jiexin Wang, Guohong Li, Shaohua Xu, Shao Shao, Min Liu, Cairong Zhong, Chung-I Wu, Suhua Shi, Ziwen He
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Whole-genome duplication (WGD), or polyploidy, events are widespread and significant in the evolutionary history of angiosperms. However, empirical evidence for rediploidization, the major process where polyploids give rise to diploid descen
Externí odkaz:
https://doaj.org/article/7da1b5147d3744c4aa986fd17cbe1bff
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-12 (2018)
Abstract Background A gene regulatory network (GRN) comprises many weak links that are often regulated by microRNAs. Since miRNAs rarely repress their target genes by more than 30%, doubts have been expressed about the biological relevance of such we
Externí odkaz:
https://doaj.org/article/96454d5da11940a4a0f9d147c446e69c
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-8 (2018)
Abstract Background New genes are constantly formed, sometimes from non-genic sequences, creating what is referred to as de novo genes. Since the total number of genes remains relatively steady, gene deaths likely balance out new births. In metazoan
Externí odkaz:
https://doaj.org/article/de7020bbd3284a259fa31601c4b74536
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Detection ofde novo, low frequency mutations is important for characterising heterogeneous cell populations, such as those found in cancer cell populations. Here the authors present o2n-seq, an ultrasensitive method with highly efficient data usage f
Externí odkaz:
https://doaj.org/article/6fd788ebdd2d4aa9a1ab98de73353467
Autor:
Xue Bai, Zhenzhen Liu, Xiaojian Shao, Di Wang, Encheng Dong, Yan Wang, Chung-I Wu, Yunfei Yuan, Xuemei Lu, Chunyan Li
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0211581 (2019)
Heterogeneity is prevalent in cancer both between and within individuals. Although a few studies have identified several circulating microRNAs (miRNAs) for cancer diagnosis, the complete plasma miRNA profile for hepatocellular carcinoma (HCC) remains
Externí odkaz:
https://doaj.org/article/bfcf09939b094b4b878960136a9ced81
Autor:
Jin Xu, Xinxin Peng, Yuxin Chen, Yuezheng Zhang, Qin Ma, Liang Liang, Ava C Carter, Xuemei Lu, Chung-I Wu
Publikováno v:
eLife, Vol 6 (2017)
Cells of multi-cellular organisms evolve toward uni-cellularity in the form of cancer and, if humans intervene, continue to evolve in cell culture. During this process, gene dosage relationships may evolve in novel ways to cope with the new environme
Externí odkaz:
https://doaj.org/article/2316644fc6114cce842a097094c839bb
Autor:
Zuyu Yang, Mingming Jia, Guojing Liu, Huaining Hao, Li Chen, Guanghao Li, Sixue Liu, Yawei Li, Chung-I Wu, Xuemei Lu, Shengdian Wang
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0187551 (2017)
With the development of high-throughput genomic analysis, sequencing a mouse primary cancer model provides a new opportunity to understand fundamental mechanisms of tumorigenesis and progression. Here, we characterized the genomic variations in a hep
Externí odkaz:
https://doaj.org/article/3feae3bf3f434306a27008679c2ae64e
Autor:
Yang Lyu, Yang Shen, Heng Li, Yuxin Chen, Li Guo, Yixin Zhao, Eric Hungate, Suhua Shi, Chung-I Wu, Tian Tang
Publikováno v:
PLoS Genetics, Vol 10, Iss 1, p e1004096 (2014)
The origin and evolution of new microRNAs (miRNAs) is important because they can impact the transcriptome broadly. As miRNAs can potentially emerge constantly and rapidly, their rates of birth and evolution have been extensively debated. However, mos
Externí odkaz:
https://doaj.org/article/ff763785b595418f86d2d00aea14eeb0
Publikováno v:
PLoS Genetics, Vol 9, Iss 2, p e1003326 (2013)
In multi-cellular organisms, tissue homeostasis is maintained by an exquisite balance between stem cell proliferation and differentiation. This equilibrium can be achieved either at the single cell level (a.k.a. cell asymmetry), where stem cells foll
Externí odkaz:
https://doaj.org/article/effc86509577487a885a280a32996368
Publikováno v:
PLoS Genetics, Vol 8, Iss 6, p e1002795 (2012)
The extent and nature of genetic incompatibilities between incipient races and sibling species is of fundamental importance to our view of speciation. However, with the exception of hybrid inviability and sterility factors, little is known about the
Externí odkaz:
https://doaj.org/article/ca10ed8dff464921a3c77e24a1374ecf