Genetic Ablation of G Protein-Gated Inwardly Rectifying K+ Channels Prevents Training-Induced Sinus Bradycardia

Autor: Isabelle Bidaud, Alicia D’Souza, Gabriella Forte, Eleonora Torre, Denis Greuet, Steeve Thirard, Cali Anderson, Antony Chung You Chong, Angelo G. Torrente, Julien Roussel, Kevin Wickman, Mark R. Boyett, Matteo E. Mangoni, Pietro Mesirca

Publikováno v: Frontiers in Physiology, Vol 11 (2021)

Background: Endurance athletes are prone to bradyarrhythmias, which in the long-term may underscore the increased incidence of pacemaker implantation reported in this population. Our previous work in rodent models has shown training-induced sinus bra

Externí odkaz: https://doaj.org/article/2cc2c4e30f3345eab7d6fbf48727ec24

Genetic ablation of G protein-gated inwardly rectifying K+ (Girk)4 channels prevents heart rate reduction induced by intensive exercise training

Autor: Angelo G. Torrente, D. Greuet, Alicia D'Souza, P. Mesirca, Matteo E. Mangoni, M. Boyett, Julien Roussel, Isabelle Bidaud, A. Chung you Chong

Publikováno v: Archives of Cardiovascular Diseases Supplements. 12:253-254

Background The incidence of brady-arrhythmias is known to be higher in athletes. In rodent models of exercise training, bradycardia results from downregulation of f-(HCN4) channels leading to a reduction of the If current in the sino-atrial node (SAN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::19a932dffc6c627c06fb1246d01d3829
https://doi.org/10.1016/j.acvdsp.2020.03.130

Normalisation de la fréquence cardiaque et de la conduction auriculo-ventriculaire dans des modèles de bradycardie congénitale par l'inhibition pharmacologique du courant IkACh

Autor: Chung You Chong, Antony

Correction de la bradycardie et des troubles de conduction dans des modèles de dysfonction congénitale de l’automatisme cardiaque par l’inhibition pharmacologique du courant IKAChLa dysfonction du nœud sinusal (DNS) est l’une des principales

Externí odkaz: http://www.theses.fr/2019MONTT002/document

Genetic Ablation of G Protein-Gated Inwardly Rectifying K⁺ Channels Prevents Training-Induced Sinus Bradycardia.

Autor: Bidaud, Isabelle, D'Souza, Alicia, Forte, Gabriella, Torre, Eleonora, Greuet, Denis, Thirard, Steeve, Anderson, Cali, Chung You Chong, Antony, Torrente, Angelo G., Roussel, Julien, Wickman, Kevin, Boyett, Mark R., Mangoni, Matteo E., Mesirca, Pietro

Publikováno v: Frontiers in Physiology; 1/20/2021, Vol. 11, pN.PAG-N.PAG, 19p

G protein-gated IKACh channels as therapeutic targets for treatment of sick sinus syndrome and heart block

Autor: Isabelle Bidaud, Pietro Mesirca, Kevin Wickman, Stéphane Evain, François Briec, Joerg Striessnig, Angelo G. Torrente, Laurine Marger, Anne Laure Leoni, Antony Chung You Chong, Flavien Charpentier, Matteo E. Mangoni, Khai Le Quang, Matthias Baudot, Joël Nargeot

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2016, 113 (7), pp.E932--941. ⟨10.1073/pnas.1517181113⟩

International audience; Dysfunction of pacemaker activity in the sinoatrial node (SAN) underlies "sick sinus" syndrome (SSS), a common clinical condition characterized by abnormally low heart rate (bradycardia). If untreated, SSS carries potentially

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4187b581f85d3f4ea5a2447cb97353a6
https://hal.archives-ouvertes.fr/hal-01831593/document