Conformational Characterization of Native and L17A/F19A-Substituted Dutch-Type β-Amyloid Peptides

Autor: Shing Jong Huang, Chu Ting Liang, Ta Hsien Lin, Chung Ying Tzeng, Kai Cyuan He, Shi Jie Huang, Chi-Fon Chang, Yi Ru Chen, Hsien-Bin Huang

Publikováno v: International Journal of Molecular Sciences
Volume 21
Issue 7
International Journal of Molecular Sciences, Vol 21, Iss 2571, p 2571 (2020)

Some mutations which occur in the &alpha
/&beta
discordant region (resides 15 to 23) of &beta
amyloid peptide (A&beta
) lead to familial Alzheimer&rsquo
s disease (FAD). In vitro studies have shown that these genetic mutation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec1953377211123f624adf2f6077e13d
https://pubmed.ncbi.nlm.nih.gov/32272787