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Autor:
Ping Heidi Iu, Yan, Helander, Sara, Zimdahl Kahlin, Anna, Wah Cheng, Chun, Chung Shek, Chi, Ho Leung, Moon, Wallner, Björn, Mårtensson, Lars-Göran, Lindqvist Appell, Malin
Publikováno v:
Scientific Reports
Thiopurine induced toxicity is associated with defects in the thiopurine methyltransferase (TPMT) gene. TPMT is a polymorphic enzyme, with most of the single nucleotide polymorphisms (SNPs) causing an amino acid change, altering the enzymatic activit