Zobrazeno 1 - 10
of 607
pro vyhledávání: '"Chung Park"'
Autor:
Chung Park, Il-Young Hwang, Serena Li-Sue Yan, Sinmanus Vimonpatranon, Danlan Wei, Don Van Ryk, Alexandre Girard, Claudia Cicala, James Arthos, John H Kehrl
Publikováno v:
eLife, Vol 12 (2024)
The trimeric SARS-CoV-2 Spike protein mediates viral attachment facilitating cell entry. Most COVID-19 vaccines direct mammalian cells to express the Spike protein or deliver it directly via inoculation to engender a protective immune response. The t
Externí odkaz:
https://doaj.org/article/253ce2a9a2df464f99f6267ec26b993b
Autor:
Serena Li-Sue Yan, Il-Young Hwang, Olena Kamenyeva, Juraj Kabat, Ji Sung Kim, Chung Park, John H. Kehrl
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Neutrophil trafficking, homeostatic and pathogen elicited, depends upon chemoattractant receptors triggering heterotrimeric G-protein Gαiβγ signaling, whose magnitude and kinetics are governed by RGS protein/Gαi interactions. RGS proteins typical
Externí odkaz:
https://doaj.org/article/0b81604be47746a48941ea2854ac34c7
Autor:
Chung Park, John H Kehrl
Publikováno v:
eLife, Vol 8 (2019)
During human immunodeficiency virus-1 (HIV-1) infection lymphoid organ follicular dendritic cells (FDCs) serve as a reservoir for infectious virus and an obstacle to curative therapies. Here, we identify a subset of lymphoid organ sinus lining macrop
Externí odkaz:
https://doaj.org/article/5d800cbf5b384f4cb643383a2446ce0e
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Thymocyte and T cell trafficking relies on signals initiated by G-protein coupled receptors. To address the importance of the G-proteins Gαi2 and Gαi3 in thymocyte and T cell function, we developed several mouse models. Gαi2 deficiency in
Externí odkaz:
https://doaj.org/article/c336187569594525942daa6b3ef48367
Autor:
Sakaorat Lertjuthaporn, Claudia Cicala, Donald Van Ryk, Matthew Liu, Jason Yolitz, Danlan Wei, Fatima Nawaz, Allison Doyle, Brooke Horowitch, Chung Park, Shan Lu, Yang Lou, Shixia Wang, Ruimin Pan, Xunqing Jiang, Francois Villinger, Siddappa N Byrareddy, Philip J Santangelo, Lynn Morris, Constantinos Kurt Wibmer, Kristin Biris, Rosemarie D Mason, Jason Gorman, Joseph Hiatt, Elena Martinelli, Mario Roederer, Dai Fujikawa, Giacomo Gorini, Genoveffa Franchini, Anush Arakelyan, Aftab A Ansari, Kovit Pattanapanyasat, Xiang-Peng Kong, Anthony S Fauci, James Arthos
Publikováno v:
PLoS Pathogens, Vol 14, Iss 8, p e1007278 (2018)
The GI tract is preferentially targeted during acute/early HIV-1 infection. Consequent damage to the gut plays a central role in HIV pathogenesis. The basis for preferential targeting of gut tissues is not well defined. Recombinant proteins and synth
Externí odkaz:
https://doaj.org/article/1d27a974a42f4d20a2e0217100ce0387
Publikováno v:
eLife, Vol 4 (2015)
The HIV-1 envelope protein gp120 is both the target of neutralizing antibodies and a major focus of vaccine efforts; however how it is delivered to B cells to elicit an antibody response is unknown. Here, we show that following local gp120 injection
Externí odkaz:
https://doaj.org/article/46b64406ccc24995b3b02ea15c4dc264
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e60139 (2013)
Germinal centers (GCs) are microanatomic structures that develop in secondary lymphoid organs in response to antigenic stimulation. Within GCs B cells clonally expand and their immunoglobulin genes undergo class switch recombination and somatic hyper
Externí odkaz:
https://doaj.org/article/26a847139b744848935d6ee95c32fda9
Autor:
Ali Vural, Travis J McQuiston, Joe B Blumer, Chung Park, Il-Young Hwang, Yolanda Williams-Bey, Chong-Shan Shi, Dzwokai Zach Ma, John H Kehrl
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e81886 (2013)
In macrophages autophagy assists antigen presentation, affects cytokine release, and promotes intracellular pathogen elimination. In some cells autophagy is modulated by a signaling pathway that employs Gαi3, Activator of G-protein Signaling-3 (AGS3
Externí odkaz:
https://doaj.org/article/00a6c4505f594d4db90ac089796632c7
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e72596 (2013)
B lymphocytes are compartmentalized within lymphoid organs. The organization of these compartments depends upon signaling initiated by G-protein linked chemoattractant receptors. To address the importance of the G-proteins Gαi2 and Gαi3 in chemoatt
Externí odkaz:
https://doaj.org/article/41b2988adcb4486fbe23160bf4c40c0b
Autor:
Chung, Park, Sohn, So Young
Publikováno v:
In Technological Forecasting & Social Change September 2020 158