Drug/Lead Compound Hydroxymethylation as a Simple Approach to Enhance Pharmacodynamic and Pharmacokinetic Properties

Autor: Soraya S. Santos, Rodrigo V. Gonzaga, Cauê B. Scarim, Jeanine Giarolla, Marina C. Primi, Chung M. Chin, Elizabeth I. Ferreira

Publikováno v: Frontiers in Chemistry, Vol 9 (2022)

Hydroxymethylation is a simple chemical reaction, in which the introduction of the hydroxymethyl group can lead to physical–chemical property changes and offer several therapeutic advantages, contributing to the improved biological activity of drug

Externí odkaz: https://doaj.org/article/378a049d6d3246ef99dfd50fb57f2055

Hydroxymethylnitrofurazone treatment in indeterminate form of chronic Chagas disease: Reduced intensity of tissue parasitism and inflammation-A histopathological study

Autor: Jean Leandro dos Santos, João Aristeu da Rosa, Chung M. Chin, Cleverton Roberto de Andrade, Cauê Benito Scarim

Publikováno v: International Journal of Experimental Pathology. 99:236-248

Hydroxymethylnitrofurazone (NFOH) is a nitrofurazone prodrug effective in vivo during acute infections, and it has less hepatotoxicity effect than the standard drug benznidazole (BZN) which has been used during short- and long-term treatment. In the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1a4dfed9e815375b2a1e5bad55f37fb
https://doi.org/10.1111/iep.12289

Anti-inflammatory action of ethanolic extract and clerodane diterpenes from Casearia sylvestris

Autor: Visioli Ehdnir De Olivejra, Rogério Cardoso Castro, Elaise Gonçalves Pierri, Alberto José Cavalheiro, Chung M. Chin, André Gonzaga dos Santos, Carla Maria Riberio Ferreira, Aristeu Gomes Tininis

Publikováno v: Revista Brasileira de Farmacognosia, Vol 27, Iss 4, Pp 495-501
Web of Science
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Revista Brasileira de Farmacognosia, Vol 27, Iss 4, Pp 495-501 (2017)
Revista Brasileira de Farmacognosia, Volume: 27, Issue: 4, Pages: 495-501, Published: AUG 2017
Revista Brasileira de Farmacognosia v.27 n.4 2017
Revista Brasileira de Farmacognosia
Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron:SBFGNOSIA

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Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e160fb7160ca52d0e8e62653d9abe979
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2017000400495&lng=en&tlng=en