Zobrazeno 1 - 10
of 372
pro vyhledávání: '"Chung K, Chu"'
Publikováno v:
Molecules, Vol 29, Iss 10, p 2390 (2024)
The FDA has approved several drugs based on the fluorinated nucleoside pharmacophore, and numerous drugs are currently in clinical trials. Fluorine-containing nucleos(t)ides offer significant antiviral and anticancer activity. The insertion of a fluo
Externí odkaz:
https://doaj.org/article/61110775879543c6b7c6a73b89501043
Autor:
Uma S. Singh, Ananda K. Konreddy, Yugandhar Kothapalli, Dongmei Liu, Megan G. Lloyd, Vidya Annavarapu, Catherine A. White, Michael. G. Bartlett, Jennifer F. Moffat, Chung K. Chu
Publikováno v:
Journal of Medicinal Chemistry. 66:7038-7053
Publikováno v:
The Journal of Organic Chemistry. 84:752-759
2'-Fluoro-6'-methylene-carbocyclic adenosine (FMCA, 12) and its phosphoramidate prodrug (FMCAP, 14) have been proven as a potential anti-HBV agent against both adefovir-resistant as well as lamivudine-resistant double (rtL180M/rtM204V) mutants. Furth
Autor:
Sau Wai Hung, Hardik Mody, Sean Marrache, Yangzom D Bhutia, Franklin Davis, Jong Hyun Cho, Jason Zastre, Shanta Dhar, Chung K Chu, Rajgopal Govindarajan
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71196 (2013)
We evaluated the potential of an investigational histone methylation reversal agent, 3-deazaneplanocin A (DZNep), in improving the chemosensitivity of pancreatic cancer to nucleoside analogs (i.e., gemcitabine). DZNep brought delayed but selective cy
Externí odkaz:
https://doaj.org/article/f4d6a8385eaa4032b590cec30340474a
Autor:
Uma S. Singh, Chung K. Chu
Publikováno v:
Nucleosides, nucleotidesnucleic acids. 39(1-3)
Synthesis of 1-((4 R,5S,6R,7R)-5,6-dihydroxy-7-(hydroxymethyl)spiro[2.4]heptan-4-yl)pyrimidine-2,4(1H,3H)-dione (12) and its phosphoramidate prodrug 18 is reported. The synthesis of the targeted co...
ß-L-1-[5-(E-2-bromovinyl)-2-(hydroxymethyl)-1,3-(dioxolan-4-yl)] uracil (L-BHDU) inhibits varicella zoster virus (VZV) replication in cultured cells, human skin, and in SCID-Hu mice with skin xenografts. VZV thymidine kinase converts L-BHDU to monop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9b733f85054fd4451182f0ac960905c
Autor:
Chung K. Chu, Caroll B. Hartline, Dongmei Liu, Jennifer F. Moffat, Judith Breuer, Chandrav De, Mark N. Prichard, Daniel P. Depledge, Uma S. Singh
ß-L-1-[5-(E-2-bromovinyl)-2-(hydroxymethyl)-1,3-(dioxolan-4-yl)] uracil (L-BHDU) prevents varicella-zoster virus (VZV) replication in cultured cells and in vivo. Its mechanism of action was investigated by evaluating its activity against related her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b694a3d352ceae87f93a4dd514d68373
Publikováno v:
Medicinal Research Reviews. 38:977-1002
Chronic hepatitis B (CHB) is one of the major causes of morbidity and mortality worldwide. Currently, clinically approved nucleos(t)ide analogs (NAs) are very efficient in reducing the load of hepatitis B virus (HBV) with minimum side effects. Howeve
Autor:
Jonathan Karn, Chung K. Chu, Nancie M. Archin, Julia Friedman, Won-Kyung Cho, Kara S. Keedy, David M. Margolis
Publikováno v:
Journal of Virology. 85:9078-9089
Latent HIV proviruses are silenced as the result of deacetylation and methylation of histones located at the viral long terminal repeat (LTR). Inhibition of histone deacetylases (HDACs) leads to the reemergence of HIV-1 from latency, but the contribu
Autor:
Ashok K. Jha, Justin G. Julander, Kie-Hoon Jung, Donald F. Smee, Jung-Ae Choi, John D. Morrey, Chung K. Chu
Publikováno v:
Antiviral Research. 86:261-267
Yellow fever virus (YFV) continues to cause outbreaks of disease in endemic areas where vaccine is underutilized. Due to the effectiveness of the vaccine, antiviral development solely for the treatment of YFV is not feasible, but antivirals that are