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Missing enzymes in the biosynthesis of the anticancer drug vinblastine in Madagascar periwinkle

Autor: Caputi, Lorenzo, Franke, Jakob, Farrow, Scott C., Chung, Khoa, Payne, Richard M. E., Nguyen, Trinh-Don, Dang, Thu-Thuy T., Carqueijeiro, Inês Soares Teto, Koudounas, Konstantinos, de Bernonville, Thomas Dugé, Ameyaw, Belinda, Jones, D. Marc, Vieira, Ivo Jose Curcino, Courdavault, Vincent, O’Connor, Sarah E.

Publikováno v: Science, 2018 Jun . 360(6394), 1235-1239.

Externí odkaz: https://www.jstor.org/stable/26498352

Two tabersonine 6,7-epoxidases start synthesis of lochnericine-type alkaloids in Catharanthus roseus

Autor: Carqueijeiro, Ines Teto, Brown, Stephanie, Chung, Khoa, Dang, Thu-Thuy, Walia, Manish, Besseau, Sébastien, Duge De Bernonville, Thomas, Oudin, Audrey, Lanoue, Arnaud, Billet, Kevin, Munsch, Thibaut, Koudounas, Konstantinos, MELIN, Céline, Godon, Charlotte, Razafimandimby, Bienvenue, De Craene, Johan-Owen, Glevarec, Gaelle, marc, Jillian, Giglioli-Guivarc'H, Nathalie, Marc, Marc, St-Pierre, Benoit, Papon, Nicolas, Andrade, Rodrigo, O'Connor, Sarah, Courdavault, Vincent

Publikováno v: Plant Physiology
Plant Physiology, American Society of Plant Biologists, 2018, 177, pp.1473-1486. ⟨10.1104/pp.18.00549⟩
Plant Physiology, American Society of Plant Biologists, 2018, pp.00549.2018. ⟨10.1104/pp.18.00549⟩

International audience; Lochnericine is a major monoterpene indole alkaloid (MIA) in the roots of Madagascar periwinkle (Catharanthus roseus). Lochnericine is derived from the stereoselective C6,C7-epoxidation of tabersonine and can be metabolized fu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::685955dc4e0ae540ccb665fc7134ec34
https://hal.archives-ouvertes.fr/hal-02144182