Zobrazeno 1 - 10
of 265
pro vyhledávání: '"Chunfu Wu"'
Autor:
Yuan Yang, Zefei Li, Yidong Wang, Jiwei Gao, Yangyang Meng, Simeng Wang, Xiaoyao Zhao, Chengfang Tang, Weiming Yang, Yingjia Li, Jie Bao, Xinyu Fan, Jing Tang, Jingyu Yang, Chunfu Wu, Mingze Qin, Lihui Wang
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 4, Pp 885-903 (2024)
Abstract Cancer is a heterogeneous disease. Although both tumor metabolism and tumor immune microenvironment are recognized as driving factors in tumorigenesis, the relationship between them is still not well-known, and potential combined targeting a
Externí odkaz:
https://doaj.org/article/66c6f65aa84a4abea4f64880aeadb2cf
Autor:
Jianmin Wang, Cheng Yang, Huashen Xu, Xinyu Fan, Lina Jia, Yang Du, Shougeng Liu, Wenjing Wang, Jie Zhang, Yu Zhang, Xiaoxue Wang, Zhongbo Liu, Jie Bao, Songping Li, Jingyu Yang, Chunfu Wu, Jing Tang, Guoliang Chen, Lihui Wang
Publikováno v:
Advanced Science, Vol 11, Iss 7, Pp n/a-n/a (2024)
Abstract Interactions between oncogenic proteins contribute to the phenotype and drug resistance. Here, EZH2 (enhancer of zest homolog 2) is identified as a crucial factor that mediates HIF‐1 (hypoxia‐inducible factor) inhibitor resistance. Mecha
Externí odkaz:
https://doaj.org/article/fa2b2c700c7e4c0fa2cf0b1ae9bc1ab8
Autor:
Qiuyue Zhang, Yajie Shi, Sen Liu, Weiming Yang, Huiping Chen, Ning Guo, Wanyu Sun, Yongshan Zhao, Yuxiang Ren, Yong Ren, Lina Jia, Jingyu Yang, Yi Yun, Guoliang Chen, Lihui Wang, Chunfu Wu
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113714- (2024)
Summary: Drug resistance is the leading problem in non-small-cell lung cancer (NSCLC) therapy. The contribution of histone methylation in mediating malignant phenotypes of NSCLC is well known. However, the role of histone methylation in NSCLC drug-re
Externí odkaz:
https://doaj.org/article/aa2c471a4f464737b940b2fbe60f876b
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 5, Pp 2107-2123 (2023)
Cognitive impairment caused by chronic cerebral hypoperfusion (CCH) is associated with white matter injury (WMI), possibly through the alteration of autophagy. Here, the autophagy–lysosomal pathway (ALP) dysfunction in white matter (WM) and its rel
Externí odkaz:
https://doaj.org/article/32082aeb026244578f46094537c0c3f9
Autor:
Wenjing Wang, Jianmin Wang, Shuai Liu, Yong Ren, Jingyu Wang, Sen Liu, Wei Cui, Lina Jia, Xing Tang, Jingyu Yang, Chunfu Wu, Lihui Wang
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-18 (2022)
Abstract Background Lung cancer is a kind of malignancy with high morbidity and mortality worldwide. Paclitaxel (PTX) is the main treatment for non-small cell lung cancer (NSCLC), and resistance to PTX seriously affects the survival of patients. Howe
Externí odkaz:
https://doaj.org/article/d9776c838d8c4a1b8953af030cd0a56a
Autor:
Jingyu Yang, Lirong Wang, Liwen Huang, Xiaohang Che, Zhen Zhang, Chunxiao Wang, Lihuan Bai, Ping Liu, Yanan Zhao, Xiaomei Hu, Bingyang Shi, Yuequan Shen, Xing‐Jie Liang, Chunfu Wu, Xue Xue
Publikováno v:
Exploration, Vol 1, Iss 1, Pp 61-74 (2021)
Abstract The distinguished properties of nanomaterials promote us to explore whether their intrinsic activities would be beneficial to disease treatment. Furthermore, understanding the molecular mechanism is thereby crucial for biomedical application
Externí odkaz:
https://doaj.org/article/112b3fe567e240d7a88841f50ff5a538
Autor:
Wenjing Wang, Mengyue Zhao, Lijuan Cui, Yong Ren, Jingyuan Zhang, Junli Chen, Lina Jia, Jiayu Zhang, Jingyu Yang, Guoliang Chen, Charles R. Ashby, Chunfu Wu, Zhe-Sheng Chen, Lihui Wang
Publikováno v:
Molecular Cancer, Vol 19, Iss 1, Pp 1-17 (2020)
Abstract Background Cisplatin is a first-line drug for the treatment of human non-small cell lung cancer (NSCLC); however, the majority of patients will develop drug resistance after treatment. In order to overcome cisplatin resistance, it is importa
Externí odkaz:
https://doaj.org/article/b9afa27f3fb3422b8b7d522183399fe5
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 39, Iss 1, Pp 1-13 (2020)
Abstract A number of novel anticancer drugs have been developed in recent years. However, the mortality of cancer patients remains high because of the emergence of drug resistance. It was reported that drug resistance might involved in changes in gen
Externí odkaz:
https://doaj.org/article/ab80990e9e37496a81574ee7c7fbb9c4
Autor:
Xiaoxia Ye, Mingming Zhu, Xiaohang Che, Huiyang Wang, Xing-Jie Liang, Chunfu Wu, Xue Xue, Jingyu Yang
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-17 (2020)
Abstract Background Microglial activation is a prominent feature of neuroinflammation, which is present in almost all neurodegenerative diseases. While an initial inflammatory response mediated by microglia is considered to be protective, excessive p
Externí odkaz:
https://doaj.org/article/98093dfa6b5542489b65ff3be5f0119d
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Methamphetamine (METH) is a highly neurotoxic psychoactive substance that can directly damage the central nervous system through prolonged use. Oxytocin (OT) has attracted much attention because of its neuroprotective effect. The purpose of this stud
Externí odkaz:
https://doaj.org/article/9ad9c44a9ff041749c105a97dbf22939