Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Chunfeng Huo"'
Autor:
Ju-Hyun Lee, Dun-Sheng Yang, Chris N. Goulbourne, Eunju Im, Philip Stavrides, Anna Pensalfini, Han Chan, Cedric Bouchet-Marquis, Cynthia Bleiwas, Martin J. Berg, Chunfeng Huo, James Peddy, Monika Pawlik, Efrat Levy, Mala Rao, Mathias Staufenbiel, Ralph A. Nixon
Publikováno v:
Nature Neuroscience. 25:688-701
Autophagy is markedly impaired in Alzheimer’s disease (AD). Here we reveal unique autophagy dysregulation within neurons in five AD mouse models in vivo and identify its basis using a neuron-specific transgenic mRFP-eGFP-LC3 probe of autophagy and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c5bc48852728fc53fbe780572287d2d
https://doi.org/10.1038/s41593-022-01084-8
https://doi.org/10.1038/s41593-022-01084-8
Autor:
Pearl P Y, Lie, Lang, Yoo, Chris N, Goulbourne, Martin J, Berg, Philip, Stavrides, Chunfeng, Huo, Ju-Hyun, Lee, Ralph A, Nixon
Publikováno v:
Science advances. 8(17)
Dysfunction and mistrafficking of organelles in autophagy- and endosomal-lysosomal pathways are implicated in neurodegenerative diseases. Here, we reveal selective vulnerability of maturing degradative organelles (late endosomes/amphisomes) to diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::03782728671ebb0c1216b139ca8bab8c
https://pubmed.ncbi.nlm.nih.gov/35486730
https://pubmed.ncbi.nlm.nih.gov/35486730
Autor:
Anna Pensalfini, Ralph A. Nixon, Chunfeng Huo, Tamotsu Yoshimori, Ju-Hyun Lee, Eunju Im, Dun-Sheng Yang, Pallabi Sarkar, Mala V. Rao, Philip Stavrides
Publikováno v:
Autophagy. 15:543-557
Autophagy-lysosome pathway (ALP) disruption is considered pathogenic in multiple neurodegenerative diseases; however, current methods are inadequate to investigate macroautophagy/autophagy flux in brain in vivo and its therapeutic modulation. Here, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a42ca512823912ce78d2ae47dfba6432
https://doi.org/10.1080/15548627.2018.1528812
https://doi.org/10.1080/15548627.2018.1528812
Autor:
Balapal S. Basavarajappa, Philip Stavrides, Chris N. Goulbourne, Monika Pawlik, Ju-Hyun Lee, Anna Pensalfini, Cynthia Bleiwas, Seonil Kim, Sandipkumar Darji, Martin J. Berg, Ying Jiang, John F. Smiley, Ralph A. Nixon, Shivakumar Subbanna, Chunfeng Huo
Publikováno v:
SSRN Electronic Journal.
Neuronal endosomal dysfunction, the earliest known pathobiology specific to Alzheimer’s disease (AD), is mediated by aberrant activation of Rab5 triggered by APP-βeta secretase cleaved C-terminal fragment (APP-βCTF). To distinguish pathophysiolog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d34bbc7bde783e5f926879b97b97951
https://doi.org/10.2139/ssrn.3512167
https://doi.org/10.2139/ssrn.3512167
Autor:
Monika Pawlik, Seonil Kim, Chunfeng Huo, Shivakumar Subbanna, Philip Stavrides, Ju-Hyun Lee, Chris N. Goulbourne, Balapal S. Basavarajappa, Sandipkumar Darji, Ying Jiang, Cynthia Bleiwas, John F. Smiley, Ralph A. Nixon, James Peddy, Anna Pensalfini, Martin J. Berg
Publikováno v:
Cell Rep
Neuronal endosomal dysfunction, the earliest known pathobiology specific to Alzheimer’s disease (AD), is mediated by the aberrant activation of Rab5 triggered by APP-β secretase cleaved C-terminal fragment (APP-βCTF). To distinguish pathophysiolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43b335d284c55ba66ea10590f9c7d19c
https://doi.org/10.1016/j.celrep.2020.108420
https://doi.org/10.1016/j.celrep.2020.108420
Autor:
Hongyan Wang, Chunfeng Huo, Bruce S. Kristal, Karen L. Smith, Kerry Cormier, Robert M. Friedlander, Irina G. Stavrovskaya, Yingjun Guan, Robert J. Ferrante, Shan Zhu, Xin Wang
Publikováno v:
European Journal of Neuroscience. 26:633-641
This study was to characterize the neuroprotective effects of nortriptyline, a tricyclic antidepressant, in mouse models of chronic neurodegeneration [amyotrophic lateral sclerosis (ALS) and Huntington's disease (HD)]. Nortriptyline was originally se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94149178eeee9a0a6bf53b59a02d161e
https://doi.org/10.1111/j.1460-9568.2007.05663.x
https://doi.org/10.1111/j.1460-9568.2007.05663.x
Autor:
Masuo Ohno, Kostantin Dobrenis, Dun-Sheng Yang, Chunfeng Huo, Ying Jiang, Ralph A. Nixon, Asok Kumar, Panaiyur S. Mohan, Steven U. Walkley, Cristin Davidson, Monika Pawlik, Mitsuo Saito, Philip Stavrides
Publikováno v:
Human Molecular Genetics. :ddx001
2-hydroxypropyl-β-cyclodextrin (CYCLO), a modifier of cholesterol efflux from cellular membrane and endo-lysosomal compartments, reduces lysosomal lipid accumulations and has therapeutic effects in animal models of Niemann-Pick disease type C and se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4fe79fcc819e57cb56e32de6c1136ec
https://doi.org/10.1093/hmg/ddx001
https://doi.org/10.1093/hmg/ddx001
Autor:
Philip Stavrides, Steven U. Walkley, Ana Maria Cuervo, Mariko Saito, Mitsuo Saito, Chunfeng Huo, Jose A. Rodriguez-Navarro, Asok Kumar, Dun-Sheng Yang, Monika Pawlik, Ralph A. Nixon
Publikováno v:
Brain : a journal of neurology. 137(Pt 12)
Autophagy, the major lysosomal pathway for the turnover of intracellular organelles is markedly impaired in neurons in Alzheimer’s disease and Alzheimer mouse models. We have previously reported that severe lysosomal and amyloid neuropathology and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98f975513aad4f7ce570079d718f8a4f
https://pubmed.ncbi.nlm.nih.gov/25270989
https://pubmed.ncbi.nlm.nih.gov/25270989
Autor:
Kyutaro Kawagishi, Bruce S. Kristal, Ethan M. Shimony, Hoon Ryu, Hans-Georg Kuhn, Xin Wang, Robert M. Friedlander, Yingjun Guan, Chunfeng Huo, Hongyan Wang
Publikováno v:
Journal of neurochemistry. 102(4)
Harnessing the regenerative potential of the central nervous system to repopulate depleted cellular populations from endogenous stem cells would be a novel approach for the treatment of neurological diseases resulting from cell death. Consequently, u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::150c879db5824485b38fe34637d6894b
https://pubmed.ncbi.nlm.nih.gov/17472707
https://pubmed.ncbi.nlm.nih.gov/17472707
Autor:
Yu Zhang, Hongyan Wang, Jean-Marie Bruey, Wenhua Zhang, Yingjun Guan, John C. Reed, Bryan E. Figueroa, Robert M. Friedlander, Xin Wang, Chunfeng Huo
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 25(50)
Caspase-1 plays a role in the pathogenesis of a variety of neurological diseases. Caspase-1 activation is an early event in models of Huntington's disease (HD). However, mechanisms regulating the activation of this apical caspase in cell death are no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b40d1086bf1915fdff063f15fd7eeb8a
https://pubmed.ncbi.nlm.nih.gov/16354923
https://pubmed.ncbi.nlm.nih.gov/16354923