Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Chune Dong"'
Autor:
Yubo Wang, Jian Min, Xiangping Deng, Tian Feng, Hebing Hu, Xinyi Guo, Yan Cheng, Baohua Xie, Yu Yang, Chun-Chi Chen, Rey-Ting Guo, Chune Dong, Hai-Bing Zhou
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 12, Pp 4963-4982 (2023)
Endocrine-resistance remains a major challenge in estrogen receptor α positive (ERα+) breast cancer (BC) treatment and constitutively active somatic mutations in ERα are a common mechanism. There is an urgent need to develop novel drugs with new m
Externí odkaz:
https://doaj.org/article/f84e6d8203d24831bb9c9b09d3cda2b2
Publikováno v:
Cell Insight, Vol 2, Iss 3, Pp 100092- (2023)
Proteolysis targeting chimera (PROTAC) degradation of pathogenic proteins by hijacking of the ubiquitin-proteasome-system has become a promising strategy in drug design. The overwhelming advantages of PROTAC technology have ensured a rapid and wide u
Externí odkaz:
https://doaj.org/article/df2437e043c9498a8d0019586d0ffaa6
Autor:
Zhichao Xu, Xinjin Liu, Xiaoyu Ma, Wenting Zou, Qi Chen, Feifei Chen, Xiaofei Deng, Jinsen Liang, Chune Dong, Ke Lan, Shuwen Wu, Hai-Bing Zhou
Publikováno v:
Cell Insight, Vol 1, Iss 3, Pp 100030- (2022)
Annual and sporadic influenza outbreaks pose a great threat to human health and the economy worldwide. Moreover, the frequent mutation of influenza viruses caused by antigen drift complicates the application of antiviral therapeutics. As such, there
Externí odkaz:
https://doaj.org/article/f54635140a86469d871bf761905de2e3
Publikováno v:
Molecules, Vol 28, Iss 5, p 2309 (2023)
Hydrogen peroxide is one of the most important reactive oxygen species, which plays a vital role in many physiological and pathological processes. A dramatic increase in H2O2 levels is a prominent feature of cancer. Therefore, rapid and sensitive det
Externí odkaz:
https://doaj.org/article/bcc5a51de1bd48ecb4d9fabc705714eb
Publikováno v:
ARKIVOC, Vol 2014, Iss 5, Pp 351-364 (2014)
Externí odkaz:
https://doaj.org/article/44c2136ae5a34d28ab9d845411f18ca0
Autor:
Jerome C Nwachukwu, Sathish Srinivasan, Yangfan Zheng, Song Wang, Jian Min, Chune Dong, Zongquan Liao, Jason Nowak, Nicholas J Wright, René Houtman, Kathryn E Carlson, Jatinder S Josan, Olivier Elemento, John A Katzenellenbogen, Hai‐Bing Zhou, Kendall W Nettles
Publikováno v:
Molecular Systems Biology, Vol 12, Iss 4, Pp n/a-n/a (2016)
Abstract Some estrogen receptor‐α (ERα)‐targeted breast cancer therapies such as tamoxifen have tissue‐selective or cell‐specific activities, while others have similar activities in different cell types. To identify biophysical determinants
Externí odkaz:
https://doaj.org/article/cf1c1a8640554626b04f8b7d235ebf06
Autor:
Ze Dong, Xiaoqing Jin, Pengcheng Wang, Chang Min, Jin Zhang, Zhe Chen, Hai-Bing Zhou, Chune Dong
Publikováno v:
ARKIVOC, Vol 2011, Iss 9, Pp 367-380 (2011)
Externí odkaz:
https://doaj.org/article/b43c9dbe890f429fa4ec0268213e9d4a
Autor:
Baohua Xie, Zhinang Yin, Zhiye Hu, Junhui Lv, Chuanqian Du, Xiangping Deng, Yuan Huang, Qiuzi Li, Jian Huang, Kaiwei Liang, Hai-Bing Zhou, Chune Dong
Publikováno v:
Journal of Medicinal Chemistry. 66:6631-6651
Publikováno v:
Bioorganic Chemistry. 137:106590
Autor:
Xinjin Liu, Jinsen Liang, Yongshi Yu, Xin Han, Lei Yu, Feifei Chen, Zhichao Xu, Qi Chen, Mengyu Jin, Chune Dong, Hai-Bing Zhou, Ke Lan, Shuwen Wu
Publikováno v:
Journal of Medicinal Chemistry. 65:3814-3832
Influenza A viruses possess a high antigenic shift, and the approved anti-influenza drugs are extremely limited, which makes the development of novel anti-influenza drugs for the clinical treatment and prevention of influenza outbreaks imperative. He