Zobrazeno 1 - 10
of 142
pro vyhledávání: '"Chun-xia Yi"'
Autor:
Ayano Shiba, Paul de Goede, Roberta Tandari, Ewout Foppen, Nikita L. Korpel, Tom V. Coopmans, Tom P. Hellings, Merel W. Jansen, Annelou Ruitenberg, Wayne I.G.R. Ritsema, Chun-Xia Yi, Joram D. Mul, Dirk Jan Stenvers, Andries Kalsbeek
Publikováno v:
Neurobiology of Sleep and Circadian Rhythms, Vol 17, Iss , Pp 100106- (2024)
Circadian disruption is an important factor driving the current-day high prevalence of obesity and type-2 diabetes. While the impact of incorrect timing of caloric intake on circadian disruption is widely acknowlegded, the contribution of incorrect t
Externí odkaz:
https://doaj.org/article/9a4fa1a71a80496e91051ba32f866208
Autor:
Felipe Correa-da-Silva, Martin J. Kalsbeek, Femke S. Gadella, Jorn Oppersma, Wei Jiang, Samantha E. C. Wolff, Nikita L. Korpel, Dick F. Swaab, Eric Fliers, Andries Kalsbeek, Chun-Xia Yi
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-13 (2023)
Abstract Evidence from animal experiments has shown that the hypothalamic paraventricular nucleus (PVN) plays a key role in regulating body weight and blood glucose levels. However, it is unclear whether neuron populations in the human PVN are involv
Externí odkaz:
https://doaj.org/article/6857b8695bea4e418b99582681d471fb
Autor:
Xiao-Lan Wang, Samantha E. C. Wolff, Nikita Korpel, Irina Milanova, Cristina Sandu, Patrick C. N. Rensen, Sander Kooijman, Jean-Christophe Cassel, Andries Kalsbeek, Anne-Laurence Boutillier, Chun-Xia Yi
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Microglia are brain immune cells responsible for immune surveillance. Microglial activation is, however, closely associated with neuroinflammation, neurodegeneration, and obesity. Therefore, it is critical that microglial immune response appropriatel
Externí odkaz:
https://doaj.org/article/b87e7dd86024424987a6511a2b35f12c
Autor:
Samantha E. C. Wolff, Xiao-Lan Wang, Han Jiao, Jia Sun, Andries Kalsbeek, Chun-Xia Yi, Yuanqing Gao
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Microglia are the immune cells of the brain. Hyperactivation of microglia contributes to the pathology of metabolic and neuroinflammatory diseases. Evidence has emerged that links the circadian clock, cellular metabolism, and immune activity in micro
Externí odkaz:
https://doaj.org/article/cdc14d7162dd41a78bcab4b8d0be5299
Autor:
Martin J.T. Kalsbeek, Samantha E.C. Wolff, Nikita L. Korpel, Susanne E. la Fleur, Johannes A. Romijn, Eric Fliers, Andries Kalsbeek, Dick F. Swaab, Inge Huitinga, Elly M. Hol, Chun-Xia Yi
Publikováno v:
JCI Insight, Vol 5, Iss 16 (2020)
Animal studies indicate that hypothalamic dysfunction plays a major role in type 2 diabetes mellitus (T2DM) development, and that insulin resistance and inflammation are important mechanisms involved in this disorder. However, it remains unclear how
Externí odkaz:
https://doaj.org/article/b9de5be741634b388701ff71860ba83b
Autor:
Anna Götz, Maarit Lehti, Elizabeth Donelan, Cynthia Striese, Sebastian Cucuruz, Stephan Sachs, Chun-Xia Yi, Stephen C. Woods, Samuel D. Wright, Timo D. Müller, Matthias H. Tschöp, Yuanqing Gao, Susanna M. Hofmann
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 9, Pp 1649-1659 (2018)
Meta-inflammation of hypothalamic areas governing energy homeostasis has recently emerged as a process of potential pathophysiological relevance for the development of obesity and its metabolic sequelae. The current model suggests that diet-induced n
Externí odkaz:
https://doaj.org/article/e48b521b49e04043b963b66df01ecbce
Autor:
Yuanqing Gao, Andrés Vidal-Itriago, Irina Milanova, Nikita L. Korpel, Martin J. Kalsbeek, Robby Zachariah Tom, Andries Kalsbeek, Susanna M. Hofmann, Chun-Xia Yi
Publikováno v:
Molecular Metabolism, Vol 7, Iss , Pp 155-160 (2018)
Objective: Leptin is a cytokine produced by adipose tissue that acts mainly on the hypothalamus to regulate appetite and energy homeostasis. Previous studies revealed that the leptin receptor is expressed not only in neurons, but also in glial cells.
Externí odkaz:
https://doaj.org/article/2e394c22479d46e49007fac6411a842f
Autor:
Yuanqing Gao, Andrés Vidal-Itriago, Martin J. Kalsbeek, Clarita Layritz, Cristina García-Cáceres, Robby Zachariah Tom, Thomas O. Eichmann, Frédéric M. Vaz, Riekelt H. Houtkooper, Nicole van der Wel, Arthur J. Verhoeven, Jie Yan, Andries Kalsbeek, Robert H. Eckel, Susanna M. Hofmann, Chun-Xia Yi
Publikováno v:
Cell Reports, Vol 20, Iss 13, Pp 3034-3042 (2017)
Consumption of a hypercaloric diet upregulates microglial innate immune reactivity along with a higher expression of lipoprotein lipase (Lpl) within the reactive microglia in the mouse brain. Here, we show that knockdown of the Lpl gene specifically
Externí odkaz:
https://doaj.org/article/278d3dbbc28e4d3894db4c7ece5dd2ca
Autor:
Yuanqing Gao, Maximilian Bielohuby, Thomas Fleming, Gernot F. Grabner, Ewout Foppen, Wagner Bernhard, Mara Guzmán-Ruiz, Clarita Layritz, Beata Legutko, Erwin Zinser, Cristina García-Cáceres, Ruud M. Buijs, Stephen C. Woods, Andries Kalsbeek, Randy J. Seeley, Peter P. Nawroth, Martin Bidlingmaier, Matthias H. Tschöp, Chun-Xia Yi
Publikováno v:
Molecular Metabolism, Vol 6, Iss 8, Pp 897-908 (2017)
Objective: The hypothalamus of hypercaloric diet-induced obese animals is featured by a significant increase of microglial reactivity and its associated cytokine production. However, the role of dietary components, in particular fat and carbohydrate,
Externí odkaz:
https://doaj.org/article/f5b9d5091cac4e21b7d0d5e9cc05918d
Autor:
Chun-Xia Yi, Marc Walter, Yuanqing Gao, Soledad Pitra, Beata Legutko, Stefanie Kälin, Clarita Layritz, Cristina García-Cáceres, Maximilian Bielohuby, Martin Bidlingmaier, Stephen C. Woods, Alexander Ghanem, Karl-Klaus Conzelmann, Javier E. Stern, Martin Jastroch, Matthias H. Tschöp
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Long-term consumption of a calorie-rich diet persistently activates brain microglia. Here, the authors show that microglial activity in mouse brains oscillates daily in conjunction with feeding, and that TNFα, secreted by activated microglia, induce
Externí odkaz:
https://doaj.org/article/6cf55e31e14747279bd3ace341933215