Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Chun-lin Zhuang"'
Autor:
Chen-xi Zhang, Ye Tu, Xiao-chen Sun, Da-gui Chen, Wan-nian Zhang, Chun-lin Zhuang, Zhi-bin Wang, Li Su
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Coronavirus Disease 2019 (COVID-19) infected by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has been declared a public health emergency of international concerns. Cytokine storm syndrome (CSS) is a critical clinical symptom of severe
Externí odkaz:
https://doaj.org/article/ff28c683463d47f897f5cfa41fac428d
Autor:
Jiao Li, Chun-Lin Zhuang
Publikováno v:
Pharmaceutical Fronts, Vol 03, Iss 04, Pp e139-e163 (2021)
Abstract The indole scaffold is one of the most important heterocyclic ring systems for pharmaceutical development, and serves as an active moiety in several clinical drugs. Fungi derived from marine origin are more liable to produce novel indole-con
Externí odkaz:
https://doaj.org/article/b7aa6a4fc7b545ceacdd7377697fb9c6
Autor:
Cheng-Shi Jiang, Chun-Lin Zhuang, Kongkai Zhu, Juan Zhang, Luis Alexandre Muehlmann, João Paulo Figueiró Longo, Ricardo Bentes Azevedo, Wen Zhang, Ning Meng, Hua Zhang
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 833-841 (2018)
A new Keap1–Nrf2 protein–protein interaction (PPI) inhibitor ZJ01 was identified from our compound library by fluorescence polarization assay, surface plasmon resonance, molecular docking and molecular dynamics simulation. ZJ01 could in vitro tri
Externí odkaz:
https://doaj.org/article/5ef3c3e0dbca4fbcb20f4af2f213d99f
Publikováno v:
Molecules, Vol 25, Iss 7, p 1581 (2020)
Scaffold hopping is a frequently-used strategy in the development of non-nucleoside reverse transcriptase inhibitors. Herein, CH(CN)-DAPYs were designed by hopping the cyano-methylene linker of our previous published CH(CN)-DABOs onto the etravirine
Externí odkaz:
https://doaj.org/article/23c81b6dca6f4d79ad0136e9d37a98b0
Autor:
Ming-Ping La, Jiao Li, Cui Li, Hua Tang, Bao-Shu Liu, Peng Sun, Chun-Lin Zhuang, Tie-Jun Li, Wen Zhang
Publikováno v:
Marine Drugs, Vol 12, Iss 12, Pp 6178-6189 (2014)
Seven new briarane diterpenoids, gemmacolides AS-AY (1–7), were isolated together with ten known analogues (8–17) from the South China Sea gorgonian Dichotella gemmacea. The structures of the new compounds were elucidated by the detailed analysis
Externí odkaz:
https://doaj.org/article/17b2cdaed1b243ec91582c7c1453a1d2
Autor:
Cui Li, Ming-Ping La, Hua Tang, Peng Sun, Bao-Shu Liu, Chun-Lin Zhuang, Yang-Hua Yi, Wen Zhang
Publikováno v:
Marine Drugs, Vol 14, Iss 11, p 201 (2016)
Seven new briarane diterpenoids, gemmacolides AZ–BF (1–7), were isolated together with eight known analogues (8–15) from the South China gorgonian Dichotella gemmacea. Their structures were elucidated based on detailed spectroscopic analysis an
Externí odkaz:
https://doaj.org/article/69874dc841b246cea5b72860d7137053
Autor:
Zhong-Yi Ling, Quan-Zhen Lv, Jiao Li, Ren-Yi Lu, Lin-Lin Chen, Wei-Heng Xu, Yan Wang, Chun-Lin Zhuang
Publikováno v:
Inflammation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb9e023f62062f284820f1026e915963
https://doi.org/10.1007/s10753-023-01842-1
https://doi.org/10.1007/s10753-023-01842-1
Publikováno v:
RSC Advances. 12:35242-35259
Cannabinoid receptors belong to the large family of G-protein-coupled receptors, which can be divided into two receptor types, cannabinoid receptor type-1 (CB1) and cannabinoid receptor type-2 (CB2). Marinol, Cesamet and Sativex are marketed CB1 drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ec6a8e5e1c7881039973d4169328e92
https://doi.org/10.1039/d2ra05661e
https://doi.org/10.1039/d2ra05661e
Autor:
Jie Tong, Xiu-ting Lan, Zhen Zhang, Yi Liu, Di-yang Sun, Xu-jie Wang, Shen-xi Ou-Yang, Chun-lin Zhuang, Fu-ming Shen, Pei Wang, Dong-jie Li
Publikováno v:
Acta pharmacologica Sinica.
Ferroptosis is a new form of regulated cell death characterized by excessive iron accumulation and uncontrollable lipid peroxidation. The role of ferroptosis in metabolic dysfunction-associated fatty liver disease (MAFLD) is not fully elucidated. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee9a04ea2459e194adc7a550d82a12b8
https://pubmed.ncbi.nlm.nih.gov/36323829
https://pubmed.ncbi.nlm.nih.gov/36323829
Publikováno v:
Journal of Agricultural and Food Chemistry. 65:8319-8330
The inhibition of porcine pancreatic α-amylase and mammalian α-glucosidase by 16 individual flavonoids was determined. The IC50 values for baicalein, (+)-catechin, quercetin, and luteolin were 74.1 ± 5.6, 175.1 ± 9.1, 281.2 ± 19.2, and 339.4 ±
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb3f47d57ec6564a499ccf2cbeef3dec
https://doi.org/10.1021/acs.jafc.7b02531
https://doi.org/10.1021/acs.jafc.7b02531