Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Chun-hong Xia"'
Publikováno v:
Frontiers in Ophthalmology, Vol 4 (2024)
Connexin 50 (Cx50) mediated signaling is essential for controlling the lens growth and size. Cx50 mutations cause microphthalmia, smaller lenses, and cataracts in humans and animals. These ocular defects have never been investigated in live Cx50 muta
Externí odkaz:
https://doaj.org/article/3a3aeb290e2e4fe79691e030739c8463
Publikováno v:
Biomedicines, Vol 11, Iss 12, p 3173 (2023)
The cGMP-phosphodiesterase 6 beta subunit (PDE6B) is an essential component in the phototransduction pathway for light responses in photoreceptor cells. PDE6B gene mutations cause the death of rod photoreceptors, named as hereditary retinitis pigment
Externí odkaz:
https://doaj.org/article/497ac1dd183149bf9311ebaf0ce7a341
Autor:
Qinrong Zhang, Yuhan Yang, Kevin J Cao, Wei Chen, Santosh Paidi, Chun-hong Xia, Richard H Kramer, Xiaohua Gong, Na Ji
Publikováno v:
eLife, Vol 12 (2023)
The retina, behind the transparent optics of the eye, is the only neural tissue whose physiology and pathology can be non-invasively probed by optical microscopy. The aberrations intrinsic to the mouse eye, however, prevent high-resolution investigat
Externí odkaz:
https://doaj.org/article/933482e627334f09b5077b1797c15202
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Cataracts, named for pathological light scattering in the lens, are known to be associated with increased large protein aggregates, disrupted protein phase separation, and/or osmotic imbalances in lens cells. We have applied synchrotron phas
Externí odkaz:
https://doaj.org/article/28788108e6464434a3ef5b28e8b7c220
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Transforming growth factor β (TGFβ) and fibroblast growth factor (FGF) signaling pathways play important roles in the proliferation and differentiation of lens epithelial cells (LECs) during development. Low dosage bFGF promotes cell proli
Externí odkaz:
https://doaj.org/article/2f183bf36d2643e7a4bf43af4296f009
Autor:
Masahiro Hitomi, Loic P. Deleyrolle, Erin E. Mulkearns-Hubert, Awad Jarrar, Meizhang Li, Maksim Sinyuk, Balint Otvos, Sylvain Brunet, William A. Flavahan, Christopher G. Hubert, Winston Goan, James S. Hale, Alvaro G. Alvarado, Ao Zhang, Mark Rohaus, Muna Oli, Vinata Vedam-Mai, Jeff M. Fortin, Hunter S. Futch, Benjamin Griffith, Qiulian Wu, Chun-hong Xia, Xiaohua Gong, Manmeet S. Ahluwalia, Jeremy N. Rich, Brent A. Reynolds, Justin D. Lathia
Publikováno v:
Cell Reports, Vol 11, Iss 7, Pp 1031-1042 (2015)
The coordination of complex tumor processes requires cells to rapidly modify their phenotype and is achieved by direct cell-cell communication through gap junction channels composed of connexins. Previous reports have suggested that gap junctions are
Externí odkaz:
https://doaj.org/article/494a4a229a984f468e7f3e93cceb546e
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e75186 (2013)
The development and maintenance of retinal vasculature require a precise balance between pro-angiogenic and anti-angiogenic factors. However, mechanisms underlying normal homeostasis of retinal vasculature and pathological changes of disrupted retina
Externí odkaz:
https://doaj.org/article/bd05d1ea9d6144a6a7dbb5ba677e3122
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52894 (2012)
The mouse semi-dominant Nm2249 mutation displays variable cataracts in heterozygous mice and smaller lenses with severe cataracts in homozygous mice. This mutation is caused by a Gja8(R205G) point mutation in the second extracellular loop of the Cx50
Externí odkaz:
https://doaj.org/article/4a2e06b66abf4d41a27e9888d42a5a0c
Publikováno v:
PLoS ONE, Vol 5, Iss 9 (2010)
Cataracts, named for any opacity in the ocular lens, remain the leading cause of vision loss in the world. Non-surgical methods for cataract prevention are still elusive. We have genetically tested whether enhanced lens gap junction communication, pr
Externí odkaz:
https://doaj.org/article/f917d4143be44348b9626d8c18495044
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11676 (2010)
The low-density lipoprotein receptor-related protein 5 (LRP5) plays an important role in the development of retinal vasculature. LRP5 loss-of-function mutations cause incomplete development of retinal vessel network in humans as well as in mice. To u
Externí odkaz:
https://doaj.org/article/9237ae14db17426a84d11aa66fc46593