Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Chun-Zhi Ai"'
Autor:
Hui-Lin Pang, Guang-Hao Zhu, Qi-Hang Zhou, Chun-Zhi Ai, Ya-Di Zhu, Ping Wang, Tong-Yi Dou, Yang-Liu Xia, Hong Ma, Guang-Bo Ge
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Human UDP-glucuronosyltransferase 1A1 (hUGT1A1) is one of the most essential phase II enzymes in humans. Dysfunction or strong inhibition of hUGT1A1 may result in hyperbilirubinaemia and clinically relevant drug/herb-drug interactions (DDIs/HDIs). Re
Externí odkaz:
https://doaj.org/article/6efdbc92ace844f68566251854ee9568
Autor:
Du-Chu Chen, You-De Liang, Liang Peng, Yi-Ze Wang, Chun-Zhi Ai, Xin-Xing Zhu, Ya-Wei Yan, Yasmeen Saeed, Bin Yu, Jingying Huang, Yuxin Gao, Jiaqi Liu, Yi-Zhou Jiang, Min Liu, Demeng Chen
Publikováno v:
Cancer Cell International, Vol 17, Iss 1, Pp 1-8 (2017)
Abstract Background Renal cell carcinoma (RCC) is the most common kidney cancer, accounting for approximately 80–90% of all primary kidney cancer. Treatment for patients with advanced RCC remains unsatisfactory. Rare cancer stem cells (CSCs) are pr
Externí odkaz:
https://doaj.org/article/33812fac17d545589e9e0983f74a9930
Publikováno v:
Informatics in Medicine Unlocked, Vol 15, Iss , Pp - (2019)
In present study we aimed to explore the possible structural feature of Cytochrome P450 (CYP) 17A1 that contributes to the metabolic specificity. The predicable 3D-QSAR (Quantitative Structure-Activity Relationships) models were first developed with
Externí odkaz:
https://doaj.org/article/716a8cb9025342c4b471630ca85191e0
Autor:
Zi-Ru Dai, Chun-Zhi Ai, Guang-Bo Ge, Yu-Qi He, Jing-Jing Wu, Jia-Yue Wang, Hui-Zi Man, Yan Jia, Ling Yang
Publikováno v:
International Journal of Molecular Sciences, Vol 16, Iss 7, Pp 14677-14694 (2015)
Early prediction of xenobiotic metabolism is essential for drug discovery and development. As the most important human drug-metabolizing enzyme, cytochrome P450 3A4 has a large active cavity and metabolizes a broad spectrum of substrates. The poor su
Externí odkaz:
https://doaj.org/article/420b2a28b34a4a08844229cd3c257d75
Autor:
Chun-Zhi Ai, Yong Liu, Wei Li, De-Meng Chen, Xin-Xing Zhu, Ya-Wei Yan, Du-Chu Chen, Yi-Zhou Jiang
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0179333 (2017)
EGFR inhibitors, even with therapeutics superiorities in anticancer, can cause idiosyncratic pulmonary and hepatic toxicities that are associated with the reactive electrophile bioactivated by Cytochrome P450s (P450s). Until now, neither has the elec
Externí odkaz:
https://doaj.org/article/f3e209b44a00476a8f97d1eec72fbcae
Autor:
Zhong-Ze Fang, Rong-Rong He, Yun-Feng Cao, Naoki Tanaka, Changtao Jiang, Kristopher W. Krausz, Yunpeng Qi, Pei-Pei Dong, Chun-Zhi Ai, Xiao-Yu Sun, Mo Hong, Guang-Bo Ge, Frank J. Gonzalez, Xiao-Chi Ma, Hong-Zhi Sun
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 12, Pp 3334-3344 (2013)
Increased levels of bile acids (BAs) due to the various hepatic diseases could interfere with the metabolism of xenobiotics, such as drugs, and endobiotics including steroid hormones. UDP-glucuronosyltransferases (UGTs) are involved in the conjugatio
Externí odkaz:
https://doaj.org/article/1d87d14bee4b47ffa1a2126d4799a234
Autor:
Chun-Zhi Ai, Shu-Wei Zhang, Ming Hao, Yong-Hua Wang, Wen-Jia Fan, Xiao-Le Zhang, Yan Li, Meng-Qi Zhang
Publikováno v:
International Journal of Molecular Sciences, Vol 12, Iss 9, Pp 5999-6023 (2011)
MGluR2 is G protein-coupled receptor that is targeted for diseases like anxiety, depression, Parkinson’s disease and schizophrenia. Herein, we report the three-dimensional quantitative structure–activity relationship (3D-QSAR) studies of a series
Externí odkaz:
https://doaj.org/article/b7914630564b4e78be2ff5169582ea45
Autor:
Du-Chu Chen, You-De Liang, Liang Peng, Yi-Ze Wang, Chun-Zhi Ai, Xin-Xing Zhu, Ya-Wei Yan, Yasmeen Saeed, Bin Yu, Jingying Huang, Yuxin Gao, Jiaqi Liu, Yi-Zhou Jiang, Min Liu, Demeng Chen
Publikováno v:
Cancer Cell International, Vol 18, Iss 1, Pp 1-1 (2018)
Upon publication of the original article [1] it was highlighted by the authors that a grant awarded to support the research work of the study was missed in the Funding Acknowledgements of their manuscript. It should also be acknowledged that the gran
Externí odkaz:
https://doaj.org/article/09a43560c75243728f180c3892dc862d
Autor:
Chun-Zhi Ai, Yin-Nan Chen, Caili Bi, Wei Li, Yue-Yue Chen, Yu-Yi Feng, Yong Liu, Yun-Ming Cao
Publikováno v:
Int. Journal of Clinical Pharmacology and Therapeutics. 60:146-158
Objective Previous clinical studies and meta-analyses have shown controversial results on the association between C3435T polymorphism of the ABCB1 gene and anti-epileptic drug (AED) resistance. Based on the fact that sample size and confounding facto
Publikováno v:
Organic Chemistry Frontiers. 9:781-787
We reported an electrocatalytic C–H activation method to construct novel highly functionalized tetrasubstituted furan derivatives, which uses allenes and 1,3-dicarbonyl compounds as substrates.