Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Chun-Wel Lin"'
Autor:
Chun Wel Lin, Michael R. Michaelides, Karen E. Asin, Kazumi Shiosaki, Erol K. Bayburt, Stanley Didomenico, Yufeng Hong, Donald R. Britton
Publikováno v:
Journal of Medicinal Chemistry. 40:1585-1599
A series of substituted 9,10-dihydroxyhexahydrobenzo[f]thieno[c]quinolines (TB[f]Q), varying with respect to the position of the thiophene relative to the benzo[f]quinoline core and the nature and position of the substituent on the thiophene, were pr
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1311:155-163
Endothelin-1 (ET-1) binding to human astrocytoma U138MG cells was time-dependent, and bound [125I]ET-1 was difficult to dissociate. The Bmax and Kd values of [125I]ET-1 binding were 70 fmol/mg and 0.07 nM, respectively. Interestingly, different from
Autor:
Chun Wel Lin, Thomas R. Miller, Alex M. Nadzan, Mark W. Holladay, James F. Kerwin, Alyssa B. O'Neill, Michael J. Bennett, Hao Bai, Michael Stashko, Jorge D. Brioni, Jeffrey W. Ralston
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:3057-3062
The development of a novel series of carbamoylamino acid benzoylpiperidides as CCK B ligands is described. Selected members of the series antagonized CCK 8 -induced calcium mobilization and showed efficacy in the mouse elevated-plus maze, a measure o
Autor:
Sharon L. Kuyper, Alex M. Nadzan, Chun Wel Lin, Michael D. Tufano, Mike Stashko, Thomas R. Miller, Mark W. Holladay, Hana Kopecka, David G. Witte, Y.‐K. Shue, George M. Carrera
Publikováno v:
Bioorganic & Medicinal Chemistry. 1:161-171
New and existing methodologies were used to prepare a series of modified CCK analogs in which each amide bond was replaced by a trans-alkene unit. The data indicate that every amide linkage at C-terminal tetrapeptide (CCK-4) region is crucial for bio
Autor:
Alex M. Nadzan, Kazumi Shiosaki, Michael A. Stashko, David G. Witte, Chun Wel Lin, Thomas R. Miller, Howard E. Morton, M.Robert Leanna
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:855-860
The backbone amide bonds in two series of tetrapeptide-based CCK-A receptor agonists were systematically replaced with the methylene amino isostere. Potent and selective pseudopeptides were identified that will facilitate our understanding of how the
Autor:
Mark W. Holladay, Chun Wel Lin, David G. Witte, Thomas R. Miller, C. A. W. Wolfram, David S. Garvey, Alex M. Nadzan, Catherine S. May
Publikováno v:
ChemInform. 22
Autor:
Kazumi Shiosaki, S. Jun. Didomenico, E. K. Bayburt, Y. Hong, Michael R. Michaelides, Donald R. Britton, Karen E. Asin, Chun Wel Lin
Publikováno v:
ChemInform. 28
Publikováno v:
ChemInform. 30
Publikováno v:
Peptides. 13:1227-1232
The interaction of the novel CCK analogs JMV-180, JMV-320, and JMV-332 with CCK-B/gastrin receptors on small cell lung cancer (SCLC) cells was investigated. JMV-180, JMV-320, and JMV-332 potently inhibited specific binding of 125I-CCK-8 to CCK-B/gast
Autor:
Mark W. Holladay, Bruce R. Bianchi, Chun Wel Lin, Michael D. Tufano, Karen E. Asin, A. L. Nikkel, L. Bednarz, Thomas R. Miller, M. J. Bennett, David G. Witte
Publikováno v:
Journal of Medicinal Chemistry. 35:2919-2928
A series of modifications of the CCK7 analogue (des-NH2)Tyr(SO3-)-Nle-Gly-Trp-Nle-Asp-Phe-NH2 was prepared and tested for binding to guinea pig CCK-A and CCK-B receptors and in CCK-A-mediated functional assays. Selected analogues also were tested for