Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Chun-Song Chua"'
Autor:
Jianghua Li, Yoshiki Ishida, Sheethal Reghu, Diep Nguyen, Guangmin Wei, Chun Song Chua, Mary B. Chan-Park
There is an urgent need for effective bactericidal agents for use in real commercial formulations because many old disinfectants, such as halogenated compounds, are now banned. Cationic polymers may have good bactericidal properties in pure water or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2176f0fb3232c1c41c7ec99e9927b71
https://hdl.handle.net/10356/138784
https://hdl.handle.net/10356/138784
Publikováno v:
Parasitology. 141:1177-1191
SUMMARYCo-chaperones are well-known regulators of heat shock protein 90 (Hsp90). Hsp90 is a molecular chaperone that is essential in the eukaryotes for the folding and activation of numerous proteins involved in important cellular processes such as s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc3f9c0bd522688fecef180ddccf119b
https://doi.org/10.1017/s0031182013002084
https://doi.org/10.1017/s0031182013002084
Publikováno v:
Journal of Industrial Microbiology & Biotechnology. May2009, Vol. 36 Issue 5, p619-633. 15p. 3 Diagrams, 4 Charts.
Publikováno v:
Cellular and Molecular Life Sciences. 69:1523-1535
Despite the absence of classical tyrosine kinases encrypted in the kinome of Plasmodium falciparum, biochemical analyses have detected significant tyrosine phosphorylation in its cell lysates. Supporting such phosphorylation is critical for parasite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2e4d3be4593d9231329523b0d07a505
https://doi.org/10.1007/s00018-011-0888-y
https://doi.org/10.1007/s00018-011-0888-y
Publikováno v:
Journal of Industrial Microbiology & Biotechnology. 36:619-633
It is approximately 60 years since the discovery of cephalosporin C in Cephalosporium acremonium. Streptomycetes have since been found to produce the structurally related cephamycin C. Studies on the biosynthetic pathways of these two compounds revea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ff6840e571dd269361bdd21aa3917c6
https://doi.org/10.1007/s10295-009-0549-4
https://doi.org/10.1007/s10295-009-0549-4
Publikováno v:
Applied and Environmental Microbiology. 74:1167-1175
Streptomyces clavuligerus deacetoxycephalosporin C synthase (ScDAOCS) is an important industrial enzyme for the production of 7-aminodeacetoxycephalosporanic acid, which is a precursor for cephalosporin synthesis. Single mutations of six amino acid r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d16406aaa2791a36ba6958c579b5258
https://doi.org/10.1128/aem.02230-07
https://doi.org/10.1128/aem.02230-07
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 70:739-747
In a previous study, the conserved arginine residue at position 306 of Streptomyces clavuligerus deacetoxycephalsoporin C synthase (scDAOCS), when mutated to leucine, resulted in 191% increase in converting ampicillin to its expanded cephalosporin mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df03679570af4bcd34f315ee2239112d
https://doi.org/10.1002/prot.21549
https://doi.org/10.1002/prot.21549
Publikováno v:
Phytochemistry. 69:66-75
Arabidopsis thaliana flavonol synthase (aFLS) catalyzes the production of quercetin, which is known to possess multiple medicinal properties. aFLS is classified as a 2-oxoglutarate dependent dioxygenase as it requires ferrous iron and 2-oxoglutarate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bbbecc23af85b153fa13b0843969ad2
https://doi.org/10.1016/j.phytochem.2007.07.006
https://doi.org/10.1016/j.phytochem.2007.07.006
Publikováno v:
The international journal of biochemistrycell biology. 44(1)
The recent recognition of Plasmodium falciparum Hsp90 (PfHsp90) as a promising anti-malaria drug target has sparked interest in identifying factors that regulate its function and drug-interaction. Co-chaperones are well-known regulators of Hsp90's ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::915f92a8c5b57640a40cb378ac739721
https://pubmed.ncbi.nlm.nih.gov/22100910
https://pubmed.ncbi.nlm.nih.gov/22100910
Autor:
Stefan H. Millson, Laurence H. Pearl, Chun-Song Chua, S. Mark Roe, Peter W. Piper, Chrisostomos Prodromou, Tiow-Suan Sim, Sigrun Polier, Svetlana Solovieva
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 25(11)
Much attention is focused on the benzoquinone ansamycins as anticancer agents, with several derivatives of the natural product geldanamycin (GdA) now in clinical trials. These drugs are selective inhibitors of Hsp90, a molecular chaperone vital for m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73c934ac0b793babe337072032104a7a
https://pubmed.ncbi.nlm.nih.gov/21778327
https://pubmed.ncbi.nlm.nih.gov/21778327